Basic Information

Insect: Oligia strigilis
Gene Symbol: -
Assembly: GCA_951800025.1
Location: OX637569.1:8476183-8498470[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 0.0036 9.7 7.2 0.0 17 63 366 412 350 455 0.87

2 2 3.9e-05 0.1 13.5 0.0 16 85 480 549 475 563 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	0.0036	9.7	7.2	0.0	17	63	366	412	350	455	0.87
2	2	3.9e-05	0.1	13.5	0.0	16	85	480	549	475	563	0.84

Sequence Information

Coding Sequence: atgAGGTGCTGTGTTCAGAATTGTACTAATGATGACTTGAAGAAAACTAATAAAAGCAATGGAATCACATTtcataaATTACCGAAGGATCCAGTCCATTGCTCTGTATGGTTAAGAGTCTTAGCTAAAGCGGGTTGCCGGCTGAGCAAGTGGCTTGTTGTCTGCTCTGATCATTTTCTACCTGAAGATTTTGACTACACACGGCCCAATCAGCGAAGAGTCAAAAGTGGAGCTGTTCCTACTCTGgtgtgcAGAGTTTGTTTAGCTTTagatgtcaaaatgtatgatatGAAGGACTTCAAATTGAGCGAAATGTTCCAAAATGTCACGGGAATAACGGCTTGCGACAAAAAGGACAGCGTACTGCATCGTGTATGTTGGGAGTGCACAGCGCGACTGACAGCGGCTGCAGCGTTCAAAGACAAAGCGCTGCTTAGCGATGCACTGCTGAAAGACCTAGTAAACATCAAACGTAGTGACATcacattattaaaacaaaatcacaTATCCCTAAAATCACCTCTAACCGTTCAGACTGTATTCACTTCATCTGATATTGAATGCGAAGATACTATAATTGAAAACAAAGAAATCGAAATATCACTCGATGATGTGACAGATATCAGAGAAAGAAAATCTAAATTACGTAttatagaagaagaaaaagagatAGAATTTGAGGAGTATGAGCCTTGGATAGATGTGCCTATGAAAACTGAAATCGAATCTGATCCTATAGCTGAAAATAACAACTTTAAAGGTAGAAAAAGCGATACATTTACAAAACCAACACATTTCAATGAAGTTTTTACATGTAGTGAAGAagatgaaataataaataacgaagaacaaataaataataatgataagaTTTTAAGTGAAGATACCGAAATTACTAGTGTACCGGTCATAAATGATCGTGGCAGCATCGTTCTAGTTGATGATAAAGAGAAGAAATTGAAGCTCGATATTGTCGTTAATATTGTGAACGAGTCCTCAAGTGAAGAAGAGCCGCTGTCTACAATTAAAGCTTTATCTGTTAATAAGTCTAAGCAAAGGGTTGGCAGTAAGGTTGGGGCTTCGAGTAAAAGAGTCAGACTCAACGACaggataaaagaaaaaataattgcgTTAAAGAAAAACGGACTCTCTGTCCGTGCAATAGCTAAGGAAACAGGACTATCGATAGCATCCGTTGATCGTTGGTGGAGCCGCTATCGCAAGAACGGTAATACATACCGTAGATCTACCACTGTAGACACAGACGAAATTGAAACAACGCAGAATTACTGCGAAAATCCGGCAGAACCTGGTAAAGAAATGGGGGCTTGCTCTGCACTTGTGAGACAAAGATTGCACGAAGCTGGGTTTGAACACATACTTATGAAAAAGCCTGAAAGAAATGGGAAAATGGAAAAGATAACAACTAGcAAACATAAAGCGCTTCATGACGATTTAAAAGAACGGATAATAGCGCTGAAGCAAGAAGGAATGACTAACAGCCGGATAGCTTATCTGTTGGATACTTCGcgaATTACAGTTCGTAAGTGGTGGAGCCGCTGGTGCAATGAAGGTCACATGCAGAACGGCAAACAGACTGGGAGGAAGAGAAAAACTACGCCTGAAGAAGATCAGCTCTTAATAGAACGGGTGACTCAAGAACAAACTGTCCATACGCCCTCCCTGGCTATAGAACTGGGCATATCTCCAGagtaa
Protein Sequence: MRCCVQNCTNDDLKKTNKSNGITFHKLPKDPVHCSVWLRVLAKAGCRLSKWLVVCSDHFLPEDFDYTRPNQRRVKSGAVPTLVCRVCLALDVKMYDMKDFKLSEMFQNVTGITACDKKDSVLHRVCWECTARLTAAAAFKDKALLSDALLKDLVNIKRSDITLLKQNHISLKSPLTVQTVFTSSDIECEDTIIENKEIEISLDDVTDIRERKSKLRIIEEEKEIEFEEYEPWIDVPMKTEIESDPIAENNNFKGRKSDTFTKPTHFNEVFTCSEEDEIINNEEQINNNDKILSEDTEITSVPVINDRGSIVLVDDKEKKLKLDIVVNIVNESSSEEEPLSTIKALSVNKSKQRVGSKVGASSKRVRLNDRIKEKIIALKKNGLSVRAIAKETGLSIASVDRWWSRYRKNGNTYRRSTTVDTDEIETTQNYCENPAEPGKEMGACSALVRQRLHEAGFEHILMKKPERNGKMEKITTSKHKALHDDLKERIIALKQEGMTNSRIAYLLDTSRITVRKWWSRWCNEGHMQNGKQTGRKRKTTPEEDQLLIERVTQEQTVHTPSLAIELGISPE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01094117;
90% Identity: iTF_00745671;
80% Identity: iTF_01095002;