Basic Information

Gene Symbol
Lztr1
Assembly
GCA_948474745.1
Location
OX419703.1:12694238-12711544[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 4.8e-15 1.4e-12 48.0 0.0 4 109 365 501 362 502 0.85
2 3 4.3e-14 1.3e-11 45.0 0.0 9 97 598 690 595 705 0.83
3 3 1.3 3.9e+02 1.6 0.0 77 106 704 733 693 736 0.80

Sequence Information

Coding Sequence
ATGAATCAGAGCCTCGGGAAGATGATAACGGAGCAGCTCCGCAATCCAAACGAGCTGGACATCAGCCTTAGGATGGAGTTTGGTCCATTTGAAACAGTACACAAGTGGAAACGCATGTCAGAGTGCTACGAGTTTGTTGGTGCCAGGAGGAGCAAACACACAGCTGTAGCATACAAAGACGCTATTTACGTGTTTGGGGGTGACAATGGCAAGTCCATGCTGAATGATCTGATCAGATTTGACATCAGAGAGAAGTCATGGACCAAGACTGGCTGCATGGGAGTGCCGCCCGCGCCGCGGTACCATCATTCTGCTGTGGTACATCGTTCATCGATGTTCGTGTTTGGCGGTTACACTGGCGACATCCTAGCGAACTCCAACCTGACCAATAAGAACGACCTGTTTGAGTACAAGTTCCCCAGCGCGCAATGGGTGCAGTGGAAGTTTACTGGACAAGAGCCCGTGCCTCGGTCAGCACACGGGGCCGCAGTGTATGATGACAAGCTATGGATATTCGCTGGTTACGATGGCAACGCGAGACTCAACGATATGTGGACCATCAATCTGTTGGGAGAGAACCACCAATGGGAGCGCATAGAGCAGAAGGGACAATGCCCCCCCACGTGCTGCAACTTCCCCGTGGCCGTCGCGCGAGGCAAGATGTTCGTGTTCAGTGGGCAGAGCGGCGCCAAGATCACTAATGCGCTATTCCAGTTCGATTTCGAGTCTCATACCTGGTCGCGCGTGTGCACGGAGCACCTACTGCGCTGGGCGGGCGGAGCGCCCGCGCGGCGGTACGGGCACGTCATGGTGGCGCACCGCGCGCAGCTCTACGTGTTCGGCGGCGCGGCCGACAACACGCTGCCCAACGACCTGCACTGCTACGACCTGGACACGCAGATATGGTCAGTGGTCCAGCCGGCCTCAGACTCGCAGATCCCTTCAGGGCGTCTGTTTCACGCAGGCGCAGTGGTGGGCGACGCGCTGTACATTTTCGGAGGAACCGTTGACAACAACGTCAGGAGCGGGGAGCTGTTCCGGTTTCAGTTATCGAACTACCCTCGCTGCACGCTACACGATGACTTCGGCCGCATACTGAAGTCTCATCAGTTCTGCGACGTACAGATACTAGTGGGCCCTGAGAAGACGTCTATTTTGGCCCACCAGGCCATATTAGCCGCCAGGTCACAGTTTCTACGAGCTAAGATCAAGGAAGCTAGAGACGATCTAACAAAACGCATAGCACCTGGCGAGGAAGAAGCATCCGAAATGGGCGCATACAAGACACCGCCACAACTGTGCGTGTTGCTACCCGAAGCCACGCCCGAGTCGTTCAACATGGTGCTCAACTACATATACACCGACAGAATAGACCCCACAGAGAAAGACGAGGACCCAGCCTCCCCGGCCACAGTGCTCCTCGTGATGGCAGTGTTGCGCCTCGCGCTGCGCCTGAACATTCCGCGCCTGCGCGGGCTGTGCGCGCGCTTCCTGCGAGCCAACCTCTGCTACGGCAACGTGTTGCAAGCGTTGCACGCCGCGCATCACGCCAACCTGACGTGTATCAAGGAGTATTGTTTAAGATTCGTAGTAAAAGACTACAACTTCACTCCGATAGTGATGTCGAAGGAGTTTGAGGAGATGGAACAGAGTCTGATGGTGGAAGTGATCAGGAGACGGCAGCAGCCGCCGCCCAAACAAACCAACGCGGTTGTACAACAGGAGTATGACGAAGAGATTATTGGCACGACGCTGGAGCAGGACATGTGCGTGCTGCTGGGCGGGGGCGCGGAGCTGGCGGACGTGCGCCTGCGCGTGGGCGCGGGCGCGGGCGCGGCGGCGCGGGGGGCGCACCGCTCCGTGCTGGCGGCGCGCGCGGCCTACTTCGAAGCTATGTTCCGCTCCTTCTCACCGCACGATAATATCGTTAATATACAAATCTGCGACACGGTGCCGTCAGAAGAAGCGTTCGACTCCTTACTTCGATATATCTACTACGGGGACACCAACATGCCGACTGAAGACTCGCTGTATCTGTTCCAAGCGCCGATATATTACGGTTTCACAAACAACCGTCTCCAAGTATTCTGCAAGCACAACTTGCAGAGCAACGTATCGCCAGAGAATGTGCTCGCAATCCTGCAAGCAGCCGACCGCATGCGGGCGACTGACATCAAGGAGTATGCGCTCAAAATGATCGTGCATCACTTTGGCCTTGTCGCGAGGCAAGACGCCATCAAGAACTTGGCCCAACCGCTCTTAGTTGACATCATATGGGCGCTAGCAGAGGAGCCACACTTCGACTCCCCCCTCCCTGTCCAACCGAGGTCATTGCCCTCGTCATCATCAGCTGATACACTGACAGAAGACCCGGAATATTCTCGACATAGATGCGGAAAATCATAG
Protein Sequence
MNQSLGKMITEQLRNPNELDISLRMEFGPFETVHKWKRMSECYEFVGARRSKHTAVAYKDAIYVFGGDNGKSMLNDLIRFDIREKSWTKTGCMGVPPAPRYHHSAVVHRSSMFVFGGYTGDILANSNLTNKNDLFEYKFPSAQWVQWKFTGQEPVPRSAHGAAVYDDKLWIFAGYDGNARLNDMWTINLLGENHQWERIEQKGQCPPTCCNFPVAVARGKMFVFSGQSGAKITNALFQFDFESHTWSRVCTEHLLRWAGGAPARRYGHVMVAHRAQLYVFGGAADNTLPNDLHCYDLDTQIWSVVQPASDSQIPSGRLFHAGAVVGDALYIFGGTVDNNVRSGELFRFQLSNYPRCTLHDDFGRILKSHQFCDVQILVGPEKTSILAHQAILAARSQFLRAKIKEARDDLTKRIAPGEEEASEMGAYKTPPQLCVLLPEATPESFNMVLNYIYTDRIDPTEKDEDPASPATVLLVMAVLRLALRLNIPRLRGLCARFLRANLCYGNVLQALHAAHHANLTCIKEYCLRFVVKDYNFTPIVMSKEFEEMEQSLMVEVIRRRQQPPPKQTNAVVQQEYDEEIIGTTLEQDMCVLLGGGAELADVRLRVGAGAGAAARGAHRSVLAARAAYFEAMFRSFSPHDNIVNIQICDTVPSEEAFDSLLRYIYYGDTNMPTEDSLYLFQAPIYYGFTNNRLQVFCKHNLQSNVSPENVLAILQAADRMRATDIKEYALKMIVHHFGLVARQDAIKNLAQPLLVDIIWALAEEPHFDSPLPVQPRSLPSSSSADTLTEDPEYSRHRCGKS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00449289;
90% Identity
iTF_01260233;
80% Identity
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