Olat000290.1
Basic Information
- Insect
- Oligia latruncula
- Gene Symbol
- -
- Assembly
- GCA_948474745.1
- Location
- OX419712.1:5440705-5459502[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 4 7.4 1.2e+04 -3.5 0.0 75 85 301 311 293 333 0.56 2 4 0.00055 0.91 9.8 0.0 18 67 347 396 341 434 0.88 3 4 0.00017 0.28 11.5 0.0 16 86 457 527 444 543 0.83 4 4 0.0069 11 6.3 0.0 19 64 550 595 539 615 0.87
Sequence Information
- Coding Sequence
- ATGGTATATTTCAGGTTACCGAAGAACCCTGAGCATTCTGCTGCATGGTTAACAGCCGTAGCTAGACTTGGTTGCCGAATGAACAAGTGTCTTGTAGTATGCTCTGAACATTTTCTACCTGAAGACTTTGATGACACACGGCACAATCAGCGAAGAGTCAAAAGTGGAGCAGTTCCTACCATAGTAACGGTGTGCAGAGTTTGCCTAGCTTTAGATGTCAAAATGTACGATATGAAAGATTTTAGATTGAGTGAAATGTTCCAAAATATCACAGGAATAACGGCTACGGTTAAAAAAAGCAGTATAGTACAGCGGGTTTGTTGGGAGTGCGCTGCGCGCCTCGCAGCGGCTGCAGCGTTCAGAGAAAAAGCGCTGTTCAGCGATGCATTGCTGAAAGACCAAGTACACATCAAAGAAAGTGACATTGCGTTATTGAAACAAAATTACAGTTCTCTAAAGTCACCTCTATCTGTTAAAACAGCAGTTTCTTCATATGATATTGAATGCGAACATACCAACTCTGAAAATAAAGAAATAAAAACATTACGGAATGAGGAGACATTTATCAAAGACAGAAAACATGAAATAAGAGTTGTTATTGAAGAAGAAAAAGAGATGGGATTCGAACAGTACGAGTCTTGGATAGATGTTCCTGTGAAAACTGAGATAGAATCTGATCCTATAGCCGATAATAATATGCGATTTCAAGATCGAACGAGTTATACATTTTCGGAACAAACACATTTCAATGATGCGTCTCCCACTGGAGATAGTGAAGATGAAATGACAAATACTGAAGTACAAACTAATAATAATGATAAGATTTTAAGTGAAGGTACCCCAAAAAAAATCCCGTACATAAATGATGCTGGAAACATCATTTTAGTAGATAAAGAGAAAAAAATTAAACCTGATGTAATTGGTAAGATTGTGGACGAGACCTCGAATGATGAAGACGCAGTATCTAGCAATAAGTGTAAGCAAGAGGTGACCAGTGAGGTTGGGCCTTCGAATAAAAGAGTAAGGCGTATGTACTTGCTTAACGACAGAATAAAAGAAAAAATAATTGAGTTGAAGAATAACGGTCTCTCAGTCGCCGCAATATCTAAAGAAACTGGAATGACGATATCATCTATAAGTTGTTGGTGGAGACGTTACCGTAAAAGCGGTAATGCATACCGAAGACCTATTACTCCAGGGGACCAGAGAACACAACAGAATTACTTTCACAACGCTGAAGAGCCTGGGAAAGAGATGGAGCCTTGTCCTGCAATAGTGAGGCAGAGATTGCACGAAGCTGGGCTTGAACACATTCTCATGAAGAAGCCTGAACGAACTGTGAATATGGGACAGAAAACTAGTACGCGTAAAGCGCTTCATGAAGATTTAAAACAGCGAATTATTGCACTGAAGCAAGAAGGAATGTCTAATAGTCGGATAGCTTACCTGTTAAATACTGCACGAAACACAGTTCAAAAGTGGTGGACTCGCTGGTGCAATGAAGGGCATATGCAAAACCACAGGCAGCCTGGAAGGAAGAGAAAAACGACGCCTCAAGAAGACCAACTCCTAATAGAGCGGGTTACTCAGGAACAAACTGTGCATACGCCCACCCTGGCTAAGGAATTTGGCATTTCTTTGAAAGTCGATGAGGAAATGAAACAACAGATAATATCGATGAAACTAAATGGCGTTTCAGTCACCGACATTGCTAACCAATTTCGAGTGCCGCGGACCACAATCTACCAATGGTGGCAGCGCTGGTGTAAGGACAACAACATAAAAATAACAAGCCATAATAACACAACTACCACAGCTGAACAAGATAAGAGTTCAGCAGAACATACTACCTTCGAAAGGATTGTGCAAACGCCATCAGTGACGTCCTCACAAATGTCGTTGTGGCAGAAACTGCCCGATATGGAATTTAAACCATAA
- Protein Sequence
- MVYFRLPKNPEHSAAWLTAVARLGCRMNKCLVVCSEHFLPEDFDDTRHNQRRVKSGAVPTIVTVCRVCLALDVKMYDMKDFRLSEMFQNITGITATVKKSSIVQRVCWECAARLAAAAAFREKALFSDALLKDQVHIKESDIALLKQNYSSLKSPLSVKTAVSSYDIECEHTNSENKEIKTLRNEETFIKDRKHEIRVVIEEEKEMGFEQYESWIDVPVKTEIESDPIADNNMRFQDRTSYTFSEQTHFNDASPTGDSEDEMTNTEVQTNNNDKILSEGTPKKIPYINDAGNIILVDKEKKIKPDVIGKIVDETSNDEDAVSSNKCKQEVTSEVGPSNKRVRRMYLLNDRIKEKIIELKNNGLSVAAISKETGMTISSISCWWRRYRKSGNAYRRPITPGDQRTQQNYFHNAEEPGKEMEPCPAIVRQRLHEAGLEHILMKKPERTVNMGQKTSTRKALHEDLKQRIIALKQEGMSNSRIAYLLNTARNTVQKWWTRWCNEGHMQNHRQPGRKRKTTPQEDQLLIERVTQEQTVHTPTLAKEFGISLKVDEEMKQQIISMKLNGVSVTDIANQFRVPRTTIYQWWQRWCKDNNIKITSHNNTTTTAEQDKSSAEHTTFERIVQTPSVTSSQMSLWQKLPDMEFKP
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00924639;
- 90% Identity
- iTF_01094132; iTF_01095024; iTF_01094892;
- 80% Identity
- iTF_01094132;