Basic Information

Insect: Oeneis ivallda
Gene Symbol: -
Assembly: GCA_029955525.1
Location: JARPMR010000017.1:3095260-3097163[-]

Transcription Factor Domain

TF Family: P53
Domain: P53 domain
PFAM: PF00870
TF Group: Beta-Scaffold Factors
Description: P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes [PMID: 20066118, PMID: 12629332, PMID: 1397838, PMID: 6544917, PMID: 19826090, PMID: 19776744, PMID: 6278740, PMID: 221923, PMID: 6318442, PMID: 20030809].This domain is found in p53 transcription factors, where it is responsible for DNA-binding. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilise the protein-DNA complex [PMID: 11780147]. Protein interactions may also serve to stabilise the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PMID: 9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.015 3.7e+02 2.3 0.0 34 61 55 82 52 89 0.91

2 8 0.014 3.6e+02 2.3 0.0 34 61 102 129 99 136 0.91

3 8 0.014 3.6e+02 2.3 0.0 34 61 149 176 146 183 0.91

4 8 0.014 3.6e+02 2.3 0.0 34 61 196 223 193 230 0.91

5 8 0.014 3.6e+02 2.3 0.0 34 61 243 270 240 277 0.91

6 8 0.014 3.6e+02 2.3 0.0 34 61 290 317 287 324 0.91

7 8 0.014 3.6e+02 2.3 0.0 34 61 337 364 334 371 0.91

8 8 0.015 3.9e+02 2.2 0.0 34 61 384 411 381 414 0.90

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.015	3.7e+02	2.3	34	61	55	82	52	89	0.91
2	8	0.014	3.6e+02	2.3	34	61	102	129	99	136	0.91
3	8	0.014	3.6e+02	2.3	34	61	149	176	146	183	0.91
4	8	0.014	3.6e+02	2.3	34	61	196	223	193	230	0.91
5	8	0.014	3.6e+02	2.3	34	61	243	270	240	277	0.91
6	8	0.014	3.6e+02	2.3	34	61	290	317	287	324	0.91
7	8	0.014	3.6e+02	2.3	34	61	337	364	334	371	0.91
8	8	0.015	3.9e+02	2.2	34	61	384	411	381	414	0.90

Sequence Information

Coding Sequence: ATGCATTATGTTATGGTACATTGTATACTTCGTCCACAGATAAGGTTCCCGCAGCGGCGTGACTCGGGCATTTACGAGTGCCAAGTGGGCACCACGCCGCCCATAGGCCACCGGATGTACCTGTCAGTTGTCGAGCCACTGACAACAATCCTGGGTGGTCCGGAGCTGTTCATCAACATGGGCAGCACAATTAATCTAACTTGCGTCGTGCAGCACTCGCCGGAGCCACCGCCCGCGATACGCTGGACTCACAATGACGAGGTAGATGCGACAGAGTTGCTGACAGCAGTCCTGGTCGGTCCGGAGCTGTTCATCAACATGGGCAGCACAATTAATCTATCGTGCGTCGTGCAGCACTCGCCGGAGCCACCGCCCGCGATACGCTGGACTCACAATGACGAGGTAGATGCGACAGAGTTGCTGACAGCAGTCCTGGTCGGTCCGGAGCTGTTCATCAACATGGGCAGCACAATTAATCTAACTTGCGTCGTGCAGCACTCGCCGGAGCCGCCGCCCGCGATACGCTGGACTCACAATGACGAGGTAGATGCGACAGAGTTGCTGACAGCAGTCCTGGTCGGTCCGGAGCTGTTCATCAACATGGGCAGCACAATTAATCTAACTTGCGTCGTGCAGCACTCGCCGGAGCCACCGCCCGCGATTCGCTGGACTCACAATGACGAGGTAGATGCGACAGAGTTGCTGACAGCAGTCCTGGTCGGTCCGGAGCTGTTCATCAACATGGGCAGCACAATTAATCTAACGTGCGTCGTGCAGCACTCGCCGGAGCCACCGCCCGCGATACGCTGGACTCACAATGACGAGGTAGATGCGACAGAGTTGCTGACAGCAGTCCTGGTCGGTCCGGAGCTGTTCATCAACATGGGCAGCACAATTAATCTAACTTGCGTCGTGCAGCACTCGCCGGAGCCGCCGCCCGCGATACGCTGGACTCACAATGACGAGGTAGATGCGACAGAGTTGCTGACAGCAGTCCTGGTCGGTCCGGAGCTGTTCATCAACATGGGCAGCACAATTAATCTAACTTGCGTCGTGCAGCACTCGCCGGAGCCGCCGCCCGCGATACGCTGGACTCACAATGACGAGGTAGATGCGACAGAGTTGCTGACAGCAGTCCTGGTCGGTCCGGAGCTGTTCATCAACATGGGCAGCACAATTAATCTAACTTGCGTCGTGCAGCACTCGCCGGAGCCGCCGCCCGCGATACGCTGGACTCATAATGACGAGGTAGGTGCGACAGAGTTGCTGATAGCAATCTTGGAAGGTCCGGAGCTGTTCATCAACATGGGAAGCATAATTAATCTAACGTCCGTCGTGCAGCACTCGCCGGAGCCGCTAGAGGTGTAA
Protein Sequence: MHYVMVHCILRPQIRFPQRRDSGIYECQVGTTPPIGHRMYLSVVEPLTTILGGPELFINMGSTINLTCVVQHSPEPPPAIRWTHNDEVDATELLTAVLVGPELFINMGSTINLSCVVQHSPEPPPAIRWTHNDEVDATELLTAVLVGPELFINMGSTINLTCVVQHSPEPPPAIRWTHNDEVDATELLTAVLVGPELFINMGSTINLTCVVQHSPEPPPAIRWTHNDEVDATELLTAVLVGPELFINMGSTINLTCVVQHSPEPPPAIRWTHNDEVDATELLTAVLVGPELFINMGSTINLTCVVQHSPEPPPAIRWTHNDEVDATELLTAVLVGPELFINMGSTINLTCVVQHSPEPPPAIRWTHNDEVDATELLTAVLVGPELFINMGSTINLTCVVQHSPEPPPAIRWTHNDEVGATELLIAILEGPELFINMGSIINLTSVVQHSPEPLEV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00801571;
90% Identity: -
80% Identity: -