Hsem016742.1
Basic Information
- Insect
- Hipparchia semele
- Gene Symbol
- -
- Assembly
- GCA_933228835.1
- Location
- CAKOGE010000183.1:1211844-1225793[-]
Transcription Factor Domain
- TF Family
- P53
- Domain
- P53 domain
- PFAM
- PF00870
- TF Group
- Beta-Scaffold Factors
- Description
- P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes [PMID: 20066118, PMID: 12629332, PMID: 1397838, PMID: 6544917, PMID: 19826090, PMID: 19776744, PMID: 6278740, PMID: 221923, PMID: 6318442, PMID: 20030809].This domain is found in p53 transcription factors, where it is responsible for DNA-binding. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilise the protein-DNA complex [PMID: 11780147]. Protein interactions may also serve to stabilise the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PMID: 9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 8 0.018 2e+02 2.0 0.0 34 61 160 187 157 197 0.91 2 8 0.019 2.2e+02 1.9 0.0 34 61 207 234 199 240 0.91 3 8 0.017 2e+02 2.1 0.0 34 61 254 281 250 291 0.91 4 8 0.019 2.2e+02 1.9 0.0 34 61 301 328 293 334 0.91 5 8 0.019 2.1e+02 1.9 0.0 34 62 348 376 344 389 0.91 6 8 0.018 2e+02 2.0 0.0 34 61 395 422 388 433 0.90 7 8 0.012 1.4e+02 2.6 0.0 33 61 441 469 429 473 0.91 8 8 0.41 4.6e+03 -2.4 0.0 34 61 489 516 488 518 0.88
Sequence Information
- Coding Sequence
- ATGACGATGGCTTTTCTATTCGGCGCGCTCGGTGCTTTGGCCCTCGTCAGCCGCACGGgttGCACAGACAACACAAATGGAGTCGATGGAGGTCAAGAGATAGAGTACACAGATGTGGACCTCGGGGTCACGCAACGAGGACCACACTTCGATGTGGCGTACTCCAGGAATGTCACAGCACTAGTGGGGAAAACCGCACAGTTGAACTGCAGGGTTCACGATCTTGGGAACAGAACGGTATCATGGATAAGGCATCGAGACATTCACCTTTTGACCTCGGGCAGGATGACCTACACGTCTGACCAGAGGTTCATTAGTGTCCACAACCCGCACACTGAGGATTGGATACTAAAGATAAGGTTTCCGCAGCGGCGTGACTCGGGCATCTACGAGTGCCAAGTGGGCACCACGCCGCCCATAGGCCACCGGATGTACCTGTCGGTTGTCGAGCCACTGACAACAATCCTGGGTGGTCCGGAGCTGTTCATCAACATGGGCAGCACAATTAATCTAACGTGCGTCGTGCAGCACTCGCCGGAGCCGCCGCCCGCGATACGCTGGACTCACAATGACGAGGTACGTGCGACAGAGCTGCTGACAATAATCCTGGGTGGTCCGGAGCTGTTCGTCAACATGGGCAGCACAATTAATCTAACGTGCGTCGTGCAGCACTCGCCGGAGCCGCCGCCCGCGATACGCTGGACTCACAATGACGAGGTACGTGCGACAGAGCTGCTGACAACAATCCTGGGTGGTCCGGAGCTGTTCATCAACATGGGCAGCACAATTAATCTAACGTGCGTCGTGCAGCACTCGCCGGAGCCGCCGCCCGCGATACGCTGGACTCACAATGACGAGGTACGTGCGACAGAGCTGCTGACAATAATCCTGGGTGGTCCGGAGCTGTTCGTCAACATGGGCAGCACAATTAATCTAACGTGCGTCGTGCAGCACTCGCCGGAGCCGCCGCCCGCAATACGCTGGACTCACAATGACGAGGTACGTGCGACAGAGCTGCTGACAACAATCCTGGGTGGTCCGGAGCTGTTCGTCAACATGGGCAGCACAATTAATCTAACGTGCGTCGTGCAGCACTCGCCGGAGCCGCCGCCCGCGATACGCTGGACTCACAATGACGAGGTACGTGCGACAGAGCTGCTGACAACAATCCTGGGTGGTTCGGAGCTGTTCATCAACATGGGCAGCACAATTAATCTAACGTGCGTCGTGCAGCACTCGCCGGAGCCGCCGCCCGCGTTACGCTGGACTCACAATGACGAGGTACGTGCGACAGAGCTGCTGACAACAATCCTGGGTGGTTCGGAGCTGTTCATCAACATGGGCAGCACAATTAATCTAACGTGCGTCGTGCAGCACTCGCCGGAGCCGCCGCCCGCGATACGCTGGACTCATAATGACGAGGTACGTGCGACAGAGCTGCTGACAACAATCCTGGGTGGTCCGGAGCTGTTCGACAACATGGGCAGCACAATTAATCTAACGTGCGTCGTGCAGCACTCGCCGGAGCCGCCGCCCGCGATACGCTGGACTCACAATGATGAGGTACGTGCGACAGAGCTGCTGACAACAATCTTGGGTGGTCCGGAACTGTCGATATGTGACCATTCAGGTAACAAACCAAGAAGCTCATAA
- Protein Sequence
- MTMAFLFGALGALALVSRTGCTDNTNGVDGGQEIEYTDVDLGVTQRGPHFDVAYSRNVTALVGKTAQLNCRVHDLGNRTVSWIRHRDIHLLTSGRMTYTSDQRFISVHNPHTEDWILKIRFPQRRDSGIYECQVGTTPPIGHRMYLSVVEPLTTILGGPELFINMGSTINLTCVVQHSPEPPPAIRWTHNDEVRATELLTIILGGPELFVNMGSTINLTCVVQHSPEPPPAIRWTHNDEVRATELLTTILGGPELFINMGSTINLTCVVQHSPEPPPAIRWTHNDEVRATELLTIILGGPELFVNMGSTINLTCVVQHSPEPPPAIRWTHNDEVRATELLTTILGGPELFVNMGSTINLTCVVQHSPEPPPAIRWTHNDEVRATELLTTILGGSELFINMGSTINLTCVVQHSPEPPPALRWTHNDEVRATELLTTILGGSELFINMGSTINLTCVVQHSPEPPPAIRWTHNDEVRATELLTTILGGPELFDNMGSTINLTCVVQHSPEPPPAIRWTHNDEVRATELLTTILGGPELSICDHSGNKPRSS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01091461;
- 90% Identity
- -
- 80% Identity
- -