Obru008804.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Odontomachus brunneus
Gene Symbol
pax2a
Assembly
GCA_010583005.1
Location
NW:350759-535595[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.8e-73 4e-70 232.9 0.3 1 125 154 278 154 278 0.99

Sequence Information

Coding Sequence
atggattttaaaaattcatctGGTACCTCTCATATGGACACAGCAACGGATGCAAGATTCCAAATGAAGGACTGGACACGATTCCAATTGCTGTCAAGCGCAAAATTCGAAAGTCATAAAGAAGGCGACGAGGGGTTGAACAGACACCTCGTCCGACAACCCGGCGAGGTGTTGTCCGAGATAGAAGAGGGTGGCGGGAGGAGAGGGCTGGACGGAGGGTGGCGTGCTATGATCAGCATGGAGCTTCCGGCACACGCGACGCAGCATGGTGCTCTACACCTGGGGGTCGGGGTCGGGGTCAATCCAGGTGACCCAGCCGGAAGTGCCTTAGCCGCCATTCACCCGCATCCCCAGGACCCTCTAGCCCTCCACCATCATAATCACGGCGCTGCGACAGCCGGAGGTATGCATGAGGACTCCAAGAAAAAACATGACGGCGGCCACGGGATACACCAGGACGGTCACGGCGGTGTCAACCAGCTCGGCGGTGTCTTCGTGAACGGAAGGCCGCTACCGGATGTAGTCAGGCAGAGGATCGTCGAGATGGCGCACAGCGGCACCCGACCGTGCGACATTTCGAGACAACTCAGGGTATCTCACGGCTGTGTATCCAAGATTCTGTCGAGGTATTACGAGACCGGTAGCTTCAAGGCTGGCGTGATAGGAGGCTCCAAGCCGAAAGTGGCGACGCCGCCGGTCGTCGACGCGATCGCCAACTACAAGAGGGACAATCCGACTATGTTCGCGTGGGAGATCAGGGACAGATTGCTGGCTGAGGGTATTTGCTCGCAGGACAACGTGCCATCCGTCTCCTCCATCAATCGGATCGTGAGGAACAAGGCGGCGGAGAAGGCGAAGCACGCGCATCAGCAACAGCAGGCGCAGCAGCAGCAAGGTCAGCAGCAAGGTCAGCCCGGATCGGGCGGTTCCGTGTCGGTGATAGCACATGCACCTGCGACGGCGGCAGGCCATCCCGCTGCCACCGCTCCCAACGCCTACAGCATCAGTGGCATCCTGGGCATCCCGGTGCACCATCAGGATCCCAATGGCAACAGCATCAAGAGGAAACGCGGCGATGACGATGACAATCGCGACCTCAACGACCACGCCGAGAACGACCTGAAGAGGCAGAGAAGCAACTACAATGGCGACCAGCTCTACTCGAACCTGTGGTCGAGTAAATGGAGCATCAAGGACGAGCACAAGTTCCTGAGCGAGctcggcggcggaggcggcggtgcGACCGGCGGCACGAACGGCGGTGGGACcggcggcggaggtggcggcggcggcggtggcggcggcggtggcggcggtggtggcggcggcggcggaggcggtggtactggcggaggcggcggcggcggtggcggcggaggtggcggcggtTACTACGAACACGGCGGATTCCCCGGGAACGCTATTGCCACCTCCGCCGAGCTGTACGACTCCCTGGGCACCATCAGCACGATGACGCAAGCGCAAACTCCCCATCTCTACACCCCGCCCATAGGGGGCACCATAGCAGGTGGTACTTTGACGCCGCTCGCGCCACTGACGATGCAAGAACTAAAATTGAGCCAAACATTGGACGGGGCTAACATGTCTCCTTACCACACCACCGCAGAGAGCAGTACCGTCGCAGTATCGTATGTAGGGGTGGGGGCCGGTGGGGGCGAGCAAAGTCCCCCGATTTCGTTGCAGAACGAGACAAACGCCACCCCCGCGGCCCCCAATACCTCCGGAGGGGATCCCGGACTGACGGTCTTGCAGCCGCCAGTTTCTCAGCCCCAAGTAGCCTCTGCGATACCGCCGTACTCGACGATGCTACCAAGTTTCGGACACTACGCTACCGGTGGTGGCGATTATGCGTACAGCGCTGCGTATTCCCAGTACTCGAGCGCGCCGTACAGCGGCTACGGTTATGGGGCGGCGACAAGCGGGTTGCTCAACTCCACGTACTACTACTGCAACGGGGACACGTCCACCCACACGTCGCAGCAGGGCGGCGGGTGCAGCAGCGGTGGTCCGGAGAGTAGTGCCGACGTGGCCAGTCGCTCGCCTCTGGCGGCCACCAGAGCCAGCAGCGGTGCCAGCGCGGCCTCGCCGACCGGAAGCGCCTGCACGAAGCCGGACCACACCTCCACGCCGACGGACCTCTACCTGGCTTGA
Protein Sequence
MDFKNSSGTSHMDTATDARFQMKDWTRFQLLSSAKFESHKEGDEGLNRHLVRQPGEVLSEIEEGGGRRGLDGGWRAMISMELPAHATQHGALHLGVGVGVNPGDPAGSALAAIHPHPQDPLALHHHNHGAATAGGMHEDSKKKHDGGHGIHQDGHGGVNQLGGVFVNGRPLPDVVRQRIVEMAHSGTRPCDISRQLRVSHGCVSKILSRYYETGSFKAGVIGGSKPKVATPPVVDAIANYKRDNPTMFAWEIRDRLLAEGICSQDNVPSVSSINRIVRNKAAEKAKHAHQQQQAQQQQGQQQGQPGSGGSVSVIAHAPATAAGHPAATAPNAYSISGILGIPVHHQDPNGNSIKRKRGDDDDNRDLNDHAENDLKRQRSNYNGDQLYSNLWSSKWSIKDEHKFLSELGGGGGGATGGTNGGGTGGGGGGGGGGGGGGGGGGGGGGGGGTGGGGGGGGGGGGGGYYEHGGFPGNAIATSAELYDSLGTISTMTQAQTPHLYTPPIGGTIAGGTLTPLAPLTMQELKLSQTLDGANMSPYHTTAESSTVAVSYVGVGAGGGEQSPPISLQNETNATPAAPNTSGGDPGLTVLQPPVSQPQVASAIPPYSTMLPSFGHYATGGGDYAYSAAYSQYSSAPYSGYGYGAATSGLLNSTYYYCNGDTSTHTSQQGGGCSSGGPESSADVASRSPLAATRASSGASAASPTGSACTKPDHTSTPTDLYLA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01089943;
90% Identity
iTF_01523304; iTF_01123011; iTF_01122379; iTF_01477512; iTF_01520173; iTF_00015984; iTF_00684112; iTF_01270449; iTF_00016626; iTF_01261783; iTF_01120155; iTF_00965981; iTF_01476120; iTF_01476865; iTF_00417503; iTF_00181249; iTF_00015319; iTF_00181914;
80% Identity
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