Basic Information

Insect: Ochropleura leucogaster
Gene Symbol: gsb
Assembly: GCA_958449745.1
Location: OY288218.1:8798711-8805428[+]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.6e-73 3.5e-70 234.5 1.1 5 125 1 121 1 121 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.6e-73	3.5e-70	234.5	1.1	5	125	1	121	1	121	0.99

Sequence Information

Coding Sequence: ATGAACCAGTTGGGCGGAGTGTTCATCAACGGTCGTCCGCTGCCGAACCACATCCGTCTGAAGATCGTGGAGATGGCGGCGGCGGGAGTGCGGCCCTGCGTCATCTCGCGCCAGCTGCGCGTCTCGCACGGCTGCGTCTCCAAGATACTCAACAGATACCAGGAAACGGGCTCCATACGTCCTGGTGTGATCGGAGGATCCAAGCCAAGAGTTGCGACTCCAGAAGTTGAGAACAGGATCGAAGAGCTGAAGAGACAAAACCCAGGTATATTTTCCTGGGAAATTAGAGATAAACTAATTAAAGAAGGCATTTGTGATAAAAACACAGCGCCGTCTGTGAGTTCGATTTCGAGACTAATAAGAGGAGGCAAAAGGGATGAATCAGATCCTAGAAGAAATCACAGCATTGATGGTATTCTAGGTCCATCATCATGCGAAGACTCAGACACCGAGTCGGAGCCTGGTATCACCCTGAAGAGGAAACAAAGAAGGTCAAGGACTACGTTCTCTGGAGACCAGCTTGAGGCTTTGGAGCGTGCTTTCACTAGGACCCAATATCCTGATGTTTATACGAGGGAAGAACTTGCGCAGAAAACCAAGCTTACTGAAGCTAGAGTTCAGgtATGGTTTTCTAACCGAAGAGCTCGACTTCGCAAGCAACTGAATTCTCAGCAACTGAGCGCTTTCAACACCATGTCCTTGCAGTCGGCGTTCCCTTCGGTTCATCAACAATATGAGCCCCCGTCTACCTTCAACGCGCAATGTGCATCTTGGCAACAATCGTATTCATCTGCGTTGGGCACCAGCTCAGTCCTGAACTCCGCTTTAGCACCATCCCTCCACCAATCTGCGTTAAGTGCTCCTTCTGTTTGCCAGTCAGCGCTTGCGTCCTCTCTACATCCTCCAACTTCAAGTTCCTTTACCTCCGGTAACCTAACGCCTCTGTCCCATTCTTCGGAACTTGCTACTCCCTTGCAAGCACCTACTGACGCCACTCCTCCTAGCTCAAGTCCTACTACGACGAGTCCTTCTGCGAACCAGACCAGTGCACTCACTTACCAACATTCAACGTACGCAAACCCCAGTGAACCACTCTCCCATCCGTATGGATACGGAGATTATTCGAAGCAGGAGCACGCTATGTCAGCGCACAACCACTGGACGACCCGGCAGCTGAGCGGACACGCGCAAAACAAACTCGCCGAAGTCAGCGCCTGGCCTGAAAACTATAGttCATTCTTTGGCACCAACGCGTCACATTACGCGTCTCACGCGCATTCTCCCACAGAGGCGAAGTCAGGCTATCCTTACTTAGGACAACTCGGCGGTATGGACATGGGCAGAGTACACTAG
Protein Sequence: MNQLGGVFINGRPLPNHIRLKIVEMAAAGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPRVATPEVENRIEELKRQNPGIFSWEIRDKLIKEGICDKNTAPSVSSISRLIRGGKRDESDPRRNHSIDGILGPSSCEDSDTESEPGITLKRKQRRSRTTFSGDQLEALERAFTRTQYPDVYTREELAQKTKLTEARVQVWFSNRRARLRKQLNSQQLSAFNTMSLQSAFPSVHQQYEPPSTFNAQCASWQQSYSSALGTSSVLNSALAPSLHQSALSAPSVCQSALASSLHPPTSSSFTSGNLTPLSHSSELATPLQAPTDATPPSSSPTTTSPSANQTSALTYQHSTYANPSEPLSHPYGYGDYSKQEHAMSAHNHWTTRQLSGHAQNKLAEVSAWPENYSSFFGTNASHYASHAHSPTEAKSGYPYLGQLGGMDMGRVH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01532882;
90% Identity: iTF_01084115; iTF_00928513; iTF_00041633; iTF_00284385; iTF_00404545; iTF_00447105; iTF_00685281; iTF_00794177; iTF_00924449; iTF_01338721; iTF_01439745; iTF_00147426; iTF_00341282; iTF_00383618; iTF_00636130; iTF_00821634; iTF_01030178; iTF_01093890; iTF_01331458; iTF_01340066; iTF_00290659; iTF_00301027; iTF_00301955; iTF_00432995; iTF_00931075; iTF_00951651; iTF_01061731; iTF_01094755; iTF_01117027; iTF_01119299; iTF_01179363; iTF_00042596; iTF_00281220; iTF_00622660; iTF_00667204; iTF_00819012; iTF_00822980; iTF_01221348; iTF_01534788; iTF_00185989; iTF_00282309; iTF_00408421; iTF_00667429; iTF_00942789; iTF_01026149; iTF_01030021; iTF_00300166; iTF_00327046; iTF_00820038; iTF_00869478; iTF_01031110; iTF_01071590; iTF_01084998; iTF_01093062; iTF_01094886; iTF_01118278; iTF_01260070; iTF_01333766; iTF_01424902; iTF_01425030; iTF_01531814; iTF_00279079; iTF_00783431; iTF_00784359; iTF_00794567; iTF_00858407; iTF_01063719; iTF_01075399; iTF_01166663; iTF_01502055; iTF_00035624; iTF_00040648; iTF_00111464; iTF_00121256; iTF_00176968; iTF_00300008; iTF_00382568; iTF_00444968; iTF_00445960; iTF_00785160; iTF_00952552; iTF_01342184; iTF_01436872; iTF_00007977; iTF_00034697; iTF_00049865; iTF_00341193; iTF_00364777; iTF_00785065; iTF_00819913; iTF_00932489; iTF_01071497; iTF_01119145; iTF_00113290; iTF_00122218; iTF_00282122; iTF_00706794; iTF_00736586; iTF_00888234; iTF_01064490; iTF_01221514; iTF_01338346; iTF_01339818; iTF_00237323; iTF_00622795; iTF_00706923; iTF_00745483; iTF_00761483; iTF_01061835; iTF_01062763; iTF_01073579; iTF_01230539; iTF_01281163; iTF_01317131; iTF_01317259; iTF_01416747; iTF_01533899; iTF_00000172; iTF_00000300; iTF_00043340; iTF_00071404; iTF_00074476; iTF_00111628; iTF_00757996; iTF_00810028; iTF_00858508; iTF_00928652; iTF_01062636; iTF_01316172; iTF_01440844; iTF_01531980; iTF_00041741; iTF_00112461; iTF_00172589; iTF_00172877; iTF_00185165; iTF_00621965; iTF_00761645; iTF_00771885; iTF_00888077; iTF_01025837; iTF_00001038; iTF_00017198; iTF_00147150; iTF_00404878; iTF_00425230; iTF_00942670; iTF_01010222; iTF_01085166; iTF_00040783; iTF_00445135; iTF_00636367; iTF_00677583; iTF_00711823; iTF_00758127; iTF_00932271; iTF_01245903; iTF_00007056; iTF_00035504; iTF_00076496; iTF_00112368; iTF_00924624; iTF_01030992; iTF_01151920; iTF_01166448; iTF_01251600; iTF_00071249; iTF_00446097; iTF_00637617; iTF_00787473; iTF_00850705; iTF_00931281; iTF_01180273; iTF_00177074; iTF_00677394; iTF_00831026; iTF_00973586; iTF_01246866; iTF_01333586; iTF_01487666; iTF_00018035; iTF_00018131; iTF_00157171; iTF_00301139; iTF_00431987; iTF_00821779; iTF_00973747; iTF_01027283; iTF_01029235; iTF_01064627; iTF_01081555; iTF_01416627; iTF_01437011; iTF_01501939; iTF_00042484; iTF_00114068; iTF_00952692; iTF_01010324; iTF_01441012; iTF_00075477; iTF_00122357; iTF_00621877; iTF_00637333; iTF_00850453; iTF_00859317; iTF_01094005; iTF_01331285; iTF_01358837; iTF_00001142; iTF_00075318; iTF_00120342; iTF_00187126; iTF_00432118; iTF_00951798; iTF_01029078; iTF_01332598; iTF_01358742; iTF_00017303; iTF_00186999; iTF_00383479; iTF_00449975; iTF_00711671; iTF_00851575; iTF_01083159; iTF_00278968; iTF_00284504; iTF_00302072; iTF_00433112; iTF_01073464; iTF_01281304; iTF_01487576; iTF_00007865; iTF_00113977; iTF_00124217; iTF_00274393; iTF_00364889; iTF_00446969; iTF_00771737; iTF_00851769; iTF_01027161; iTF_01063609; iTF_01251705; iTF_01259929; iTF_01342073; iTF_01415801; iTF_01491737; iTF_01533785; iTF_01538713; iTF_00006938; iTF_00039770; iTF_00290522; iTF_00408250; iTF_00745658; iTF_00809914; iTF_00960794; iTF_01117178; iTF_01152122; iTF_01180186; iTF_01534650; iTF_00049755; iTF_00074331; iTF_00273467; iTF_00382427; iTF_00736475; iTF_00819131; iTF_01028123; iTF_01075227; iTF_00185276; iTF_00783292; iTF_00859420; iTF_00869596; iTF_01083292; iTF_01285404; iTF_01285500; iTF_01538588; iTF_00121405; iTF_00280989; iTF_00685405; iTF_00822749; iTF_00831165; iTF_00960893; iTF_01092925; iTF_01246685; iTF_01415677; iTF_00034558; iTF_00076318; iTF_00274302; iTF_00326942; iTF_01081438; iTF_01179454; iTF_00120479; iTF_00237535; iTF_00273567; iTF_00425343; iTF_00809087; iTF_01230367; iTF_01245791; iTF_01439903; iTF_00039648; iTF_00043456; iTF_00124096; iTF_00157056; iTF_00186144; iTF_00450080; iTF_00784256; iTF_00787616; iTF_00808960; iTF_01028256; iTF_01118112; iTF_01316320; iTF_01491904; iTF_00354945; iTF_00356162; iTF_00355117; iTF_00355982; iTF_00700865; iTF_00698241; iTF_00701002; iTF_00702858; iTF_00704810; iTF_00701935; iTF_00704975; iTF_00698128; iTF_00705969; iTF_00701810; iTF_00703794; iTF_00705842; iTF_00700083; iTF_00699956; iTF_00699030; iTF_00697305; iTF_00696442; iTF_00702747; iTF_00703899; iTF_00699133; iTF_00697182; iTF_00696351; iTF_01205665; iTF_01203203; iTF_01203109; iTF_01204743; iTF_01204847; iTF_01205560; iTF_01202332; iTF_01202430; iTF_00710882; iTF_00710982; iTF_00710168; iTF_00710046; iTF_01091554; iTF_01091879; iTF_01142978; iTF_00855746; iTF_00855851; iTF_01141518; iTF_01141519; iTF_00790228; iTF_01141620; iTF_01141621; iTF_01143062; iTF_00790105; iTF_01500962; iTF_00844171; iTF_00844312; iTF_01501080; iTF_01546498; iTF_01542933; iTF_01546614; iTF_01542815; iTF_00022659; iTF_00022757; iTF_01463113; iTF_01463219; iTF_00159683; iTF_00778721; iTF_00782497; iTF_00213410; iTF_00774371; iTF_00777347; iTF_00212421; iTF_00777862; iTF_00248041; iTF_00776617; iTF_00782602; iTF_00806698; iTF_00779371; iTF_00779468; iTF_00778637; iTF_00775119; iTF_00806544; iTF_00247153; iTF_00775217; iTF_00775985; iTF_00781681; iTF_00722898; iTF_00777970; iTF_00723027; iTF_00776694; iTF_00780215; iTF_00774456; iTF_00780120; iTF_00159802; iTF_00780986; iTF_00247899; iTF_00247036; iTF_00775900; iTF_00781789; iTF_01181853; iTF_00212286; iTF_00777278; iTF_00780894; iTF_00213279; iTF_01181760; iTF_00353027; iTF_00352898; iTF_00876131; iTF_00874305; iTF_00876009; iTF_00875274; iTF_00875160; iTF_00874425; iTF_01018435; iTF_01018531; iTF_01017594; iTF_01017694; iTF_01134755; iTF_01135719; iTF_00021193; iTF_00021292; iTF_00156111; iTF_00325232; iTF_00156210; iTF_00342162; iTF_00462357; iTF_01134645; iTF_00342070; iTF_00462231; iTF_01135612; iTF_00325341; iTF_00155166; iTF_00155262; iTF_01494915; iTF_01495638; iTF_01495006; iTF_01495742; iTF_00657156; iTF_00656993; iTF_00818308; iTF_00648963; iTF_01207971; iTF_00649060; iTF_00825700; iTF_00895908; iTF_01209061; iTF_00206854; iTF_00825446; iTF_00125095; iTF_00818216; iTF_00033770; iTF_00033675; iTF_01209228; iTF_00032878; iTF_00206959; iTF_00634448; iTF_00044465; iTF_00206034; iTF_01208148; iTF_00055253; iTF_00055381; iTF_00649878; iTF_00649974; iTF_00125015; iTF_00826937; iTF_00895769; iTF_00143034; iTF_00205914; iTF_00826682; iTF_00044315; iTF_00634171; iTF_00032764; iTF_00142941; iTF_00275109; iTF_00177924; iTF_01403397; iTF_01336808; iTF_00178122; iTF_01336685; iTF_00275230; iTF_01403295; iTF_00457989; iTF_00621195; iTF_00457100; iTF_00457196; iTF_00457872; iTF_00621083; iTF_00467301; iTF_00468140; iTF_00468045; iTF_00467378; iTF_00723922; iTF_01334805; iTF_01334614; iTF_00723833; iTF_01360581; iTF_00441458; iTF_01360466; iTF_00441344; iTF_00682374; iTF_00683175; iTF_00681516; iTF_00681613; iTF_00682224; iTF_00683283; iTF_00166791; iTF_00166883; iTF_00207879; iTF_00207718; iTF_00651592; iTF_01220513; iTF_00640130; iTF_01220619; iTF_00072588; iTF_00072782; iTF_00012793; iTF_00012987; iTF_00640287; iTF_00651712; iTF_01387560; iTF_01387466; iTF_01386576; iTF_01386672; iTF_01388433; iTF_01385556; iTF_01385720; iTF_01388318; iTF_00358377; iTF_00357454; iTF_00357280; iTF_00358528; iTF_00842505; iTF_00842632; iTF_00835562; iTF_00836526; iTF_00835410; iTF_00837330; iTF_00836376; iTF_00837502; iTF_00255851; iTF_00256706; iTF_00256881; iTF_00255671; iTF_00063436; iTF_01429793; iTF_00428971; iTF_01429901; iTF_00428081; iTF_00427958; iTF_00428855; iTF_00063551; iTF_00289580; iTF_00654245; iTF_00289481; iTF_01072459; iTF_00751885; iTF_00752038; iTF_00878733; iTF_00878817; iTF_01090541; iTF_01090727; iTF_00288014; iTF_00287918; iTF_00770958; iTF_00771047; iTF_00909678; iTF_00909605; iTF_00935694; iTF_00935534; iTF_00994222; iTF_00994318; iTF_00674159; iTF_00674257; iTF_01161166; iTF_01161318; iTF_00197327; iTF_00197229; iTF_00235823; iTF_00236595; iTF_00235732; iTF_00236502; iTF_00926447; iTF_00926571; iTF_00149232; iTF_00410250; iTF_01133579; iTF_00654092; iTF_00772846; iTF_00149360; iTF_00411280; iTF_01072304; iTF_00148433; iTF_00871155; iTF_00411412; iTF_00148341; iTF_00409144; iTF_00410136; iTF_00412376; iTF_00680378; iTF_00871258; iTF_00412475; iTF_00772732; iTF_00680509; iTF_00409246; iTF_01133695; iTF_00856592; iTF_00856458; iTF_00923472; iTF_00923649; iTF_00984880; iTF_00985063; iTF_01157520; iTF_01157702; iTF_01490000; iTF_01490092; iTF_00208689; iTF_00208847; iTF_00659409; iTF_00659314; iTF_00689361; iTF_00689255; iTF_01206514; iTF_01206414; iTF_01453234; iTF_01453139; iTF_01451324; iTF_01451421; iTF_00406707; iTF_00406575; iTF_01076243; iTF_01076457; iTF_00913460; iTF_00913574; iTF_01429012; iTF_01428907; iTF_00647957; iTF_00647853; iTF_00834485; iTF_00834603; iTF_01020245; iTF_01020083; iTF_01021173; iTF_01021047; iTF_00204986; iTF_00205087; iTF_00795670; iTF_00795553; iTF_00824566; iTF_00843497; iTF_00843354; iTF_00796381; iTF_00824702; iTF_00796479; iTF_00896630; iTF_00896774; iTF_01503702; iTF_01503847; iTF_01561878; iTF_01561972; iTF_00642199; iTF_00642284; iTF_01153943; iTF_01153714; iTF_01436055; iTF_01435913; iTF_00197976; iTF_00198085; iTF_00250424; iTF_00250321; iTF_00407544; iTF_00407427; iTF_00695512; iTF_00695339; iTF_01156408; iTF_01156139; iTF_01443800; iTF_01443690; iTF_00195033; iTF_00195127; iTF_00323353; iTF_00323473; iTF_00354041; iTF_00353935; iTF_00791161; iTF_00791053; iTF_01034553; iTF_00960130; iTF_01033699; iTF_00958631; iTF_00959369; iTF_00959274; iTF_01033580; iTF_00958546; iTF_01034394; iTF_00960027; iTF_01041721; iTF_01041610; iTF_01172185; iTF_01172327; iTF_01359577; iTF_01359718; iTF_01502937; iTF_01502832; iTF_00011802; iTF_00011954; iTF_00954266; iTF_00953377; iTF_00953478; iTF_00801814; iTF_00801658; iTF_00954427; iTF_01154874; iTF_01155144; iTF_00077339; iTF_00077448; iTF_00832891; iTF_00832763; iTF_01264251; iTF_01264583; iTF_01341243; iTF_01341002; iTF_01564411; iTF_01564618; iTF_00204316; iTF_00204229; iTF_00827836; iTF_00827922; iTF_00957820; iTF_00957913; iTF_00171613; iTF_00171720; iTF_00249661; iTF_00249573; iTF_00889181; iTF_00889039; iTF_00967901; iTF_00967995; iTF_01192477; iTF_01192679; iTF_01312189; iTF_00113185; iTF_01312093; iTF_00006142; iTF_00006245; iTF_01302302; iTF_01302147; iTF_01361470; iTF_01361584; iTF_01494174; iTF_01494267; iTF_00114911; iTF_00114796; iTF_00908671; iTF_00908811; iTF_01016639; iTF_01016421; iTF_01367871; iTF_01367542; iTF_00150336; iTF_00150494; iTF_00390336; iTF_00390234; iTF_01203904; iTF_01204003; iTF_01377440; iTF_01377329; iTF_01452288; iTF_01452190; iTF_01182530; iTF_01509571; iTF_00810853; iTF_01182833; iTF_00810995; iTF_00662943; iTF_01509439; iTF_00663040; iTF_00666500; iTF_00666370; iTF_00907013; iTF_00036481; iTF_00277313; iTF_01438753; iTF_00025123; iTF_00375171; iTF_00970371; iTF_00660164; iTF_01402596; iTF_01129989; iTF_00373766; iTF_00656102; iTF_01527142; iTF_00907847; iTF_00658216; iTF_01115657; iTF_00363882; iTF_00448874; iTF_00971082; iTF_00277227; iTF_01438892; iTF_00038733; iTF_00036654; iTF_00374062; iTF_01124558; iTF_00655951; iTF_00449072; iTF_00180433; iTF_01115570; iTF_01176146; iTF_00905971; iTF_00970259; iTF_01129908; iTF_01402676; iTF_01437940; iTF_00180309; iTF_00375029; iTF_00660277; iTF_00906101; iTF_01125301; iTF_00037782; iTF_00907734; iTF_01125430; iTF_01337718; iTF_00363992; iTF_00922841; iTF_01526874; iTF_00025211; iTF_00038555; iTF_00922748; iTF_00971196; iTF_01525788; iTF_00906909; iTF_01525981; iTF_00037630; iTF_00658366; iTF_01437823; iTF_01176064; iTF_01337632; iTF_01506305; iTF_01078052; iTF_01079753; iTF_01507022; iTF_01507182; iTF_01079857; iTF_01506196; iTF_01507927; iTF_01078169; iTF_01508029; iTF_00009865; iTF_00008947; iTF_01464019; iTF_00008756; iTF_00010009; iTF_01464126; iTF_00840169; iTF_00840264; iTF_01080588; iTF_01080681; iTF_01078930; iTF_01079023; iTF_01140882; iTF_01140805; iTF_01082292; iTF_01082406; iTF_01140085; iTF_01140166; iTF_00985848; iTF_00986021; iTF_00726140; iTF_00726326; iTF_00673469; iTF_00673354; iTF_00161511; iTF_00162727; iTF_00162358; iTF_00161403; iTF_00419722; iTF_00418952; iTF_00418827; iTF_00419635; iTF_00420403; iTF_00421300; iTF_00421212; iTF_00420509; iTF_00461526; iTF_00461415; iTF_01173242; iTF_01173132; iTF_01335786; iTF_00361473; iTF_01170565; iTF_00686310; iTF_00737449; iTF_00632618; iTF_00737323; iTF_01171435; iTF_00638508; iTF_00377071; iTF_00686191; iTF_00632722; iTF_00638610; iTF_00361590; iTF_01170425; iTF_01171322; iTF_01335900; iTF_00376958; iTF_00119564; iTF_00119465; iTF_00321553; iTF_00321455; iTF_00661140; iTF_01529157; iTF_01528138; iTF_00662190; iTF_00662095; iTF_01529051; iTF_01528253; iTF_00661246; iTF_00267038; iTF_00267149; iTF_00123339; iTF_00123209; iTF_01158924; iTF_01158563; iTF_00947853; iTF_00947756; iTF_01332402; iTF_01569293; iTF_01569130; iTF_00026702; iTF_00026815; iTF_00027711; iTF_00027616; iTF_00345774; iTF_00345669; iTF_01279118; iTF_01124458; iTF_01279220; iTF_01282239; iTF_01282080; iTF_00709200; iTF_00709032; iTF_01280241; iTF_01280044; iTF_00317971; iTF_00318062; iTF_01148051; iTF_01147986; iTF_01533011; iTF_01532882; iTF_01545715; iTF_01545615; iTF_01401140; iTF_01401260; iTF_01362327; iTF_01362407; iTF_01099801; iTF_01099713; iTF_01197689; iTF_01197574; iTF_01219737; iTF_01219641; iTF_00276380; iTF_00276130; iTF_01543900; iTF_01543753; iTF_01547516; iTF_01547385; iTF_01561084; iTF_01560985; iTF_00144541; iTF_00144422; iTF_01496415; iTF_01496545; iTF_01544735; iTF_01544843;
80% Identity: iTF_01084115;