Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.8e-27 1.6e-23 84.0 10.8 70 270 50 245 4 266 0.73

2 3 0.79 7.2e+03 -3.5 3.9 1 19 265 283 265 318 0.67

3 3 0.1 9.2e+02 -0.5 0.7 132 166 294 328 283 329 0.79

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.8e-27	1.6e-23	84.0	10.8	70	270	50	245	4	266	0.73
2	3	0.79	7.2e+03	-3.5	3.9	1	19	265	283	265	318	0.67
3	3	0.1	9.2e+02	-0.5	0.7	132	166	294	328	283	329	0.79

Coding Sequence: ATGGATCCGTCGCGCATCCGCAAGCGAATTTTGAAGCGTCAGCAATGCGTAGAAGAAAATCATGTTGACAAGACAGAAACGGCGAGTTGGCGCGGCGACAACCGGGCTGCGCTCAATCCGGGCGTGGTGCTCTCGCCGCGGTGGTGGTGGAGGTCTGAGGACTCAGCGGACGACACCTTCAATGTCAAAGATCTTAGGCACGAATTAAAAGAAATGCAGGAGAAGTGCCGCAAGGCGATGATACTTCACGCCCAGCCGGACAACGACACGGCGGCCCTTGGCTACCAGCTCAAGCTGCTCAATGACAAGATAGTGGAGCTTCACGAGACGTACGCGCAGCTGCAGCTGGAGCATATAGAGAAATGCTCCGCTCACGAGCGTTTAAATTGTGAGCACGTAGCTCTGAAGCGCGAGTTGCTGCTGGCGCGAGACTCGGCGGCCGCGGTCGCAGGCTACACCTTCGTGGACGCGGGGCCCGAGGGGGTCAGTGTGAGAGGCGGCGCGGTCGTGGATTCCGAGGGGGCCCAGCCGGAGGGCTGTTCCGCGCTCGCGCTCGAGTCGCATCACTCGCAACAGCAGCTTGATGACGCCCTGGAAAGAAAGTTGCAGAAGTTGTTAGGCTCGATGCAGTCGCTAGAGTTAGAGGTGCGCAAGTTAAAGCTACAGTTAAACGACGAGCGAGCTGCTAGACAGTACGGAGTGGCCAATCATCACGACCACGAGTATGATAATGAATTGGAGACGGTTCGCAAGGCGCTGACGGAGGCAAATGGTCGAGCGGCGCGTGCGGAGGCGGAGGCGGCGCTGCAGGCGGCGAGATGCGTGCGTCTCGAGGCGCAGGTGACGCGGACGTTGGCCCGGCTGCTCAAGCAGGAAGCACAGGACTACACAAGGTTGCAGCGAGAGGCAAGAGCAGCTCTCAATCGAGTCGAGGACTTGAAGACGGCAAACAGCAACTTAACCAAAGGTCTGGACAAACTCAAAAACTTGTGA
Protein Sequence: MDPSRIRKRILKRQQCVEENHVDKTETASWRGDNRAALNPGVVLSPRWWWRSEDSADDTFNVKDLRHELKEMQEKCRKAMILHAQPDNDTAALGYQLKLLNDKIVELHETYAQLQLEHIEKCSAHERLNCEHVALKRELLLARDSAAAVAGYTFVDAGPEGVSVRGGAVVDSEGAQPEGCSALALESHHSQQQLDDALERKLQKLLGSMQSLELEVRKLKLQLNDERAARQYGVANHHDHEYDNELETVRKALTEANGRAARAEAEAALQAARCVRLEAQVTRTLARLLKQEAQDYTRLQREARAALNRVEDLKTANSNLTKGLDKLKNL

Sequence clustering based on sequence similarity using MMseqs2