Basic Information

Gene Symbol
ZEB2
Assembly
GCA_947347705.1
Location
OX374621.1:1304232-1314187[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.0021 0.24 12.8 0.4 2 22 504 524 503 527 0.89
2 11 0.0022 0.25 12.8 5.0 1 23 541 564 541 564 0.96
3 11 0.04 4.3 8.8 1.5 1 22 569 590 569 593 0.89
4 11 2.5 2.7e+02 3.2 0.1 2 23 614 638 613 638 0.86
5 11 0.012 1.4 10.4 0.2 2 21 644 663 643 664 0.94
6 11 1.3e-05 0.0015 19.8 1.6 1 23 723 744 723 744 0.98
7 11 0.00013 0.015 16.6 2.1 1 19 750 768 750 770 0.96
8 11 0.12 13 7.3 2.9 3 23 776 798 774 798 0.93
9 11 0.11 12 7.5 6.6 1 21 805 825 805 827 0.96
10 11 0.0061 0.67 11.4 1.6 1 21 833 853 833 858 0.92
11 11 0.71 78 4.9 2.5 1 23 864 887 864 887 0.95

Sequence Information

Coding Sequence
ATGCTGTCGCCGCGGGATGACGACGACGATGACAGCCACCTGTGCATCAAGTGCAACGCAACTATCGTCGGCCTCGAGAATTACGTGAAGCACAGAAAACAAAGATGTGGAAAAGTAGCCAAACAAGAGACGAAGGCAGATATCTCCAGCATTGACACATTAGACCCCACATACAGTCTTGGCGCAGATGTCTTTTTTCAATCTTTGGAATTGCAGAGCAGCGTTAAAAAGACTTCTTTATCCAGACTGACTCCACCAATACCTATATCGAAAGCAGTTTTAGATTCAAAAACGACTTTGGTAGAAGCTTCTACGTCGAGAGATCTGCCTCGAATGAGTCCTTTGGAAACTAATTTGAGAGAAGAAGACTGGATTGGAGGACACTCGTTAAGGATCAGTGGGCACGAAGATAATCAAACTAAACTAATTAATGCTGTAGCCAGTATCAGCGGAACGGCTAAAAAAGAAATACCCAGGTCTACTTATAGTATTGCAGCGTATAATGATTTCAAATGTGACGAGGACTTTGACGAGCTAGATGAATCTGAAGAAGAAGATGAAGATGAACCACATGCAAGTAGTAGTAAGTGGAAGCCACCGCCAAATTACACTGGTGGGAAATGGCGACCCGCTTCACCTGATCACGAAGACTGGGATATGAGGGAAGATCAAGAGCATACAGGAGGAAAGTGGAAGCCTATAATGACGGACTCCAATGAAAGAGATGACGATTATGATGCACCACCTCCGGGACACACGAAAGGGAAATGGGTTCCAGGTCATGAAAAAACACAAATCATGCAACCGACAATACAGTCAAAGGGTTCGGTGCAGTACTGGTGTGGTCCCTGTAATCGACGTTTAGGGTCACGCGCTATTTATGAAAAACATTTAATGTCTAGTTTGCATATGCGAAAGGTTCTTCCAGAACACGAATTAGAGTTTTCCGGGCATTTAGAACCGATAAGTTCAGTTAAAAGGCCCTCGCGTCCATCTCGCTTTACTGATGATAGCGTTTACGCACAGACTCAGAAGAAATCGGCAAAAATAGTTAAGCCGAAACTGACGGTCAAAATAGAAAAGAAAAAACGGAAACGAAATCCGACTTTTGTTCACTGCTCCGGCTGTAAATCACGAGTGAGGCTACATTTGATGGGAAAGCATTTAATTTCTCATTACCACTTTCGAAAAGCCACTGACATTAAAAGTGAATCATATCAGCAGTTAATTCTGGATAATATAGACGCCATCGTACATCAATCACCCTTTCAATGCAGCCCATGTAAATTTTATACAAACTGGCTGTCCAATTTTATGCAACATTGGTTTTCTGAAGAGCATGAAAATACAATAGCCACGTTAGAAGGTAGATACTGGTGTTCCTTTTGCAAGTTTGATTGTGTAACATCACAAGAAATGTTGCAGCACTTGTCTGGGTCAGACCACAGCGAAGTAGTCGCTGTGATAAACAGATCAATGCCCATAATTATTAGAAAAAAAACTATTATTACATGTGAAACGTGTGGCGAAGAGTTCAAATATAACGTAGAAATGAGAAGACATTTTAACAGAACTGGCCATAAACCAGCTTATACTGCCACAGACGATTACCAAGAGTTTCATAAATGTCAACATTGCAATACTAAATTCAAATCCTCTTTAGCACTTGCAGCCCATTTAAAATACAAGCACAAACAAAAGGCTTATTTCTGTCTTGTATGCACAATGACTTTCAAAACTTTTGATGAAGCTAAGCGTCATCGCTATACTTCGGCTCATCGTATTAGAAGAAAAGAAATATTGATTAGCAAGGGAGTACCTGTGAAGAATTTGAGCAAAAAATGTCCGTATTGTTCTGATAACGTGGTGTTGAGAAGCATTCTGCAGTTGAAGGAACACATCCGTGTTGTGCATCCTGAAATAAAAAAGAGATGTCCTAAATGCGGCATGTCCTTTATCCTATTTCAAGAAGTCACTCGCCACGTCAGAAGTAACGCGTGCCAGTTTCAGGATTTCCAACCGCTCGATTCTTCCCTCATGTGGAACTGTAGCCAATGTTTGTTCAGCACAGACTCGCAGGCCGAATGTTATTACCACGAGGTGTTGCACACAGAGACTATTAAAGAATATCGGAAAGCCGGTGATAAAGATGTACTGGTGGAAATGTATCCTTGTCCTATCTGCTCTAAAACGTTCAGAAAAAGATATCTCCGTCAGCATTTGAGGCTGCATACTTTTGAGAGACCCTTCGTGTGCTCAACATGCTCGAAAACATTCTCTAATAGGAGCGCACTAAGCCGTCACGGATGCGATGCTGTGAGATGCTGCCCGCACGATGGCTGCACCTACGTCGCTTCCACTCCTGCGCATTTAGCCAGGCATAGAACTAGTCATGGTGAAGATATAAAAAATTATGAATGTACCCTTTGCCCGTTCAAGACCAACCATTCCAGTCATATGGAGAGACATTTGCGATGCCATAAAGGTGTAAAGCCGTACGCTTGTCCACATTGTGAATTTACTTGCGGCAGTTTGGAAAATCTCCGAAAACACGTCATAAAAAGTGGTCGCCATCCTGGGAAGTTCTTATATCACTGCCAGTCCTGTGTCTACCATACCAACACAGCTACTGAATTACGTGCTCATTTCGCTACAATTCATGCCGACAAATACGACACAAAATCTGCTATACAAGCTGTTAAAATGGTTTTAATTAAAGACAATAAATAA
Protein Sequence
MLSPRDDDDDDSHLCIKCNATIVGLENYVKHRKQRCGKVAKQETKADISSIDTLDPTYSLGADVFFQSLELQSSVKKTSLSRLTPPIPISKAVLDSKTTLVEASTSRDLPRMSPLETNLREEDWIGGHSLRISGHEDNQTKLINAVASISGTAKKEIPRSTYSIAAYNDFKCDEDFDELDESEEEDEDEPHASSSKWKPPPNYTGGKWRPASPDHEDWDMREDQEHTGGKWKPIMTDSNERDDDYDAPPPGHTKGKWVPGHEKTQIMQPTIQSKGSVQYWCGPCNRRLGSRAIYEKHLMSSLHMRKVLPEHELEFSGHLEPISSVKRPSRPSRFTDDSVYAQTQKKSAKIVKPKLTVKIEKKKRKRNPTFVHCSGCKSRVRLHLMGKHLISHYHFRKATDIKSESYQQLILDNIDAIVHQSPFQCSPCKFYTNWLSNFMQHWFSEEHENTIATLEGRYWCSFCKFDCVTSQEMLQHLSGSDHSEVVAVINRSMPIIIRKKTIITCETCGEEFKYNVEMRRHFNRTGHKPAYTATDDYQEFHKCQHCNTKFKSSLALAAHLKYKHKQKAYFCLVCTMTFKTFDEAKRHRYTSAHRIRRKEILISKGVPVKNLSKKCPYCSDNVVLRSILQLKEHIRVVHPEIKKRCPKCGMSFILFQEVTRHVRSNACQFQDFQPLDSSLMWNCSQCLFSTDSQAECYYHEVLHTETIKEYRKAGDKDVLVEMYPCPICSKTFRKRYLRQHLRLHTFERPFVCSTCSKTFSNRSALSRHGCDAVRCCPHDGCTYVASTPAHLARHRTSHGEDIKNYECTLCPFKTNHSSHMERHLRCHKGVKPYACPHCEFTCGSLENLRKHVIKSGRHPGKFLYHCQSCVYHTNTATELRAHFATIHADKYDTKSAIQAVKMVLIKDNK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00006670;
90% Identity
-
80% Identity
-