Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_905220585.1
Location
HG992246.1:11636785-11647795[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1e-14 5.2e-11 42.5 0.0 5 69 752 815 748 818 0.93

Sequence Information

Coding Sequence
ATGGCTGTTAAAAAATGTTGTGTAGAAAACTGTAATTCTTCCTCAACAAGAAAAGAAGATATTGGTGTAACATATCACAAGTTTCCAAAAGATAAGACATTACGTGAAACATGGGTATTAATTACACGTTATAGGCACACTAACACTGCACACTGTAGTTATGTGTGCTCTCGACACTTTTGTAAAAGTGATTTTCAAATTTATCAGGACTCGAAATATGTTCTTAAGTCAGATGCTGTACCATCAATATTTTCTTGGGCCATGACAGATACAAAAATGGAAACAAACCCTACCAAAGATGTTGACGAAAAGTTAAACTTATCTACCAGCAGTAAAGAATCGGAGAGTGAAAATGTGGAGGCTATAAAAAAATATATAGAAGATCAAGAAAAAGAGATCAAGGAAAGGGAGAGTCAGAAAGACAATGACAAAGCTCTAGAGAAGATAGAAGCGGAACAAAAAGGAGATGATATAGTCAATCAAATGGAAGTGATAGACAGAGAAGAACCTATTGTAATAGCTACAAGTGTTATGGATATGATATTAAGTGAATCAGAAGCTAAAATTGCAAATAATAAAGACATTAAACCTATTACAAAAGATAGCTTAAGTTCTAAAGATAAAGGTAGTAGTAGTATGGCTTTATCAGTGGGCTCAAAGGTTGAGGTCAAGGATTTTGGTGAGATCTGGTATGCGGCTGCAATCGCTGAAGTTGATTATGATGAAATGGAAGTATTAGTACACTATAATCCTGTATCAAACAAGCATGATGAATGGATAAATGTAAGTAGTCCTAGGCTAAGGCCGATGACTATTACTACTTCACCCATTCCTTCAATATCTTCAGCTGTCCAAAATCCAACACCTACAGACAATGCTGAAATCAAGAACGAAGTTAAGCAAGAAGACAAAACAAAAATTGAATTTGTAGTGGGAGAAAGATGTTTGGCACGTTGGAGAGATAATCGAAGATTTGTCGCTACCATCTCTAATGATTTGGGAAATGGCCATTACGAGGTTATATTTGATGACGGTTTTCAATGGAAGTGCAGTACATCAAGGTTATATAAATTGAAGTCTTCTTCAGGAAGACCAGGAAGTTCTGAGTGTTTAACTGTTGACACTTCTGCCTCCTCTGCCGCATCAACTCCATCTCCAACTCTAGCTGGTGCTGGACCTACTGTTGCATCTTCTCCAAGTGCTCACACAACATTTCCTACCTTCCATACACATCTCTTTGATCCCACACGTGATTATTTAGGTTCCAAGAGTGAACGTCGCGAAATGAAAAGAAAATTAAATATAAAAGAAATTTTCAATATTGGCCAGAAAAAACAAAGGAAGAAAACAAAATTAACTGAAGAGAAAGCCGATATTAAGATTGTGAGAGACAAGAAACCTAAAATATTGAAAAGGAAAATTATACCTGAACCCACAGAGGAAGTTAAACTTGACGTCAAGATGGATATACCAGATGCAGTAGCTTCCATCATAGGAACTGTTGCTAAAGAAGATGTTGATGAATCAATAATCAGTGATGAAAAAACTGAGACTGTTATACCACAATCACCTGAAATTAAATCTGAAGGAGTCAAGGAAGAACAGGAAATTGACAAAGTTAAGAAAGAGGAACCGGTCGATATAAGTACAGTGGGCAGTTACTCAGATCTTGTAATACCTAGTGATTTAGGTTTGGAGTCTGATATATACGTTGAACCGGTCATAGAGGAAGAAGTGAAATTGGAAAAGTTCGAAAAACCAGATGATAGTAAACAAGAGGTTATCGAGAAAATGAAAGTCGTTATAAACAAACTAGAAGATGGCTTGCATCAAATGGAAAAGGCAGATTCGCCTAAACTAGTCGTGGAAATAGAACCGCTCGTAGAAACCAAGCCAGTAAGCGAAGTTGATAAAGAAGTGTATACAGAAAAAGAAAAGACTAAGAAGCTATCTAAGATAAAGAAAAATAAGAAAATGAGATTGTTACAGGAGAAGAAGGTAAAGAAGCAGGTGGAGAAGGTGAAAAATGAGTTGGAGGAGATGAAACGGCAAGTCGAGGAAATGAGAAAACAAATGTTGTTGAAGACTGAGGAATTATCGACGTCGACCAGGCCTCTTGAAATGCCGGAAAGTTTTTTGTTACCGGGTGAATGGTGTTGTAAGTGGATCAATGGTCAGCCAGTTGGTACAGTCAGTGAAATTGAAGCCGAGGTTAAGGATGGTAGCAAATTACCATTACCACGTAGAAGTGTGCAGGTCGAAGATAAAAGATTACCTCCAGGTTGGACGAAGCACATGGTACGACGAAGTCTGGGGCAATCGGCTGGGAAATGGGATGTGGTTTTAGTTGGACCAGATAACCGACGTTTCCACACTAAAACTGACATGCGGGCCTTTTTGGAACACGTTCCGGATGAATCGTTGAAGTCTTACGAATTTGCACTGTTAGATTTCGGTGTACATCTCAAGTTGTCTAGACGTATGGGATGGGTCAGCCATACCGAGGAAGGGACGCTACCGCCGACTAGTGTAAATACACTGTCGCCGTTGGTTAAGAGGAAAAAAATAAGCCACAAAAGAAAGGAGGATAAGAAAGAGAGGAAACGCAAAAGGCAAAAGATTATATCGAATGATACACCAAGTACGAGTAGTCAAGCTTTATTGGATTTGTCAGAAGCGGGAACGGACATATCCTTCGAGAATCCGCCCCTAGAGGATGGTTATGTATATGTTGGATCGCTAAAAGTCCAGATCATAGAAAACTTGCTTCGCTGCCCAGCGGAAGGTTGTTACAAGAACTTCAGAAATAATACATTATTGCAAATGCACATAAAGCACTATCACCGCGAAATGAGGAAGATGTTGGGAGCAACACCTAAAGTATTAGATTTGGCCAGAAAGAGAACGAAACCAACGAGTATCGAACCGCCGAAGCCACGATATGAACCAGAATCAAAGATCATCAAGGTAAAATTACCGAGACTACCGAAGCGCATAATTGAAGAAACGAAAATTGAAATAAAACCTAAAAAAGAGGAATCGCCCTCCGAACTCCATATCGATATACCAGTCGCACCTACAAGCAAAACAAATTCACCAGTACCAAGATCTCAAGATTCACCAAAACTACGTCAAGCACTCGCAAATAAACCGGTGAAACGACCAAAAGTTTTGCTCCCCGTTCGGAGACCAGATCCGGAACCGATTGTAGAAAAAGAAATCGAAATACCAACTCTCGATTACGAGGAAGTCGCGACGGAAAATGAATTTGAAAGGCCAACGGAAAGTTTGGATTTTGAATCGGAAATTTCTGCTCATACTGTTACGAAGGCGCTGGATGAAACACGAAAGAAGTCTGAGAAAAAACGTAAATGTTTTTCGACAATATCTAAAAAACCGATGAGTGAGGAAGATGAGTGGTATGGTGGTAATTCGGATGTGGATACCAGATCGAGCTGTCCGGGTTCCGGGACGCCGGACTCTAAAACCATGGACAAGGCAATGACTCAGCAAGCGGTGTCATCGGAGTCTAATAATGAAGACCAGAAAGAAAACAGCACGTACATTTATACTGAAACCGGCGAACGAGTGAAGATTGAGCGCATGAAACGCGAAGAAATAATAAGCTGCCACTGCGGGTTTCGTGAGGAGGACGGGCTGATGGTGCAGTGCGAGCTGTGTCTGTGCTGGCAACACGCGCTCTGCCACAACATACAGAAGGAATCCGAGGTCCCTGACAAGTATACCTGCAGTATCTGCCTTAACCCACGGCGCGGTCGACGTTCGAAGAGATTCCTCCACGACCAGGATCGCCTATACGAGGGGCTCCTCCCGGGGGCGAAGCCCTGCGAATCACTTCGTAGATCGCACGAGCTATCTGGAAATTTGTTGCGGATACAGGATGCCTTGCACGCCCTTCGAGTCAAGTACTATGTCGCTACTAAAAAGGATCATCCGAAGTTATATCTCTGGGCCAAAGATTGGGAGAATGCTGAAGTGACCTTAACACAAGAGAGACTCACCTCGGACTACTCGGACCTCAGTATAATGTTGAATAATATTGGCAAGGAGAACTTACCAGTGAAGCCGGAGGAAGTTAAAGATGGCCATTTGGACATAAGGACGCCTATCATTGATGACCCTGATCAAGATAGATTCACTCAGTCATCAAATTCTCTGCTAACTTTGACGACGGCGTTGTCCAGTCCGAGCGGTGGACCGTCTCTCGATTTACCGATAACTACATCAGAACTAGAACGGCTGGCGAAATCTGTCCAAGAACAAGAAGTGCCGAGAAACGTGATGGTGCCCCAGCCGGAAGCCGCGATAGAGAACGGCGCGTGTCGCGAGAGGCTGCTGCGCCACGTGCAGCGCTGCCAGGCGCTCATTGACGCGAGGCTCGACTCATTTGAAGCACAGGTTGCTGAACTGGAGTCCCAAGATCCGTCCTTTGAAGATGATGAAACAGCTGATTACTTCCCACGAACTAAACAGACCATACAAATGCTAATGCGTGACCTGGATACCATGGAAGAACTTGGTATTATCACTTAA
Protein Sequence
MAVKKCCVENCNSSSTRKEDIGVTYHKFPKDKTLRETWVLITRYRHTNTAHCSYVCSRHFCKSDFQIYQDSKYVLKSDAVPSIFSWAMTDTKMETNPTKDVDEKLNLSTSSKESESENVEAIKKYIEDQEKEIKERESQKDNDKALEKIEAEQKGDDIVNQMEVIDREEPIVIATSVMDMILSESEAKIANNKDIKPITKDSLSSKDKGSSSMALSVGSKVEVKDFGEIWYAAAIAEVDYDEMEVLVHYNPVSNKHDEWINVSSPRLRPMTITTSPIPSISSAVQNPTPTDNAEIKNEVKQEDKTKIEFVVGERCLARWRDNRRFVATISNDLGNGHYEVIFDDGFQWKCSTSRLYKLKSSSGRPGSSECLTVDTSASSAASTPSPTLAGAGPTVASSPSAHTTFPTFHTHLFDPTRDYLGSKSERREMKRKLNIKEIFNIGQKKQRKKTKLTEEKADIKIVRDKKPKILKRKIIPEPTEEVKLDVKMDIPDAVASIIGTVAKEDVDESIISDEKTETVIPQSPEIKSEGVKEEQEIDKVKKEEPVDISTVGSYSDLVIPSDLGLESDIYVEPVIEEEVKLEKFEKPDDSKQEVIEKMKVVINKLEDGLHQMEKADSPKLVVEIEPLVETKPVSEVDKEVYTEKEKTKKLSKIKKNKKMRLLQEKKVKKQVEKVKNELEEMKRQVEEMRKQMLLKTEELSTSTRPLEMPESFLLPGEWCCKWINGQPVGTVSEIEAEVKDGSKLPLPRRSVQVEDKRLPPGWTKHMVRRSLGQSAGKWDVVLVGPDNRRFHTKTDMRAFLEHVPDESLKSYEFALLDFGVHLKLSRRMGWVSHTEEGTLPPTSVNTLSPLVKRKKISHKRKEDKKERKRKRQKIISNDTPSTSSQALLDLSEAGTDISFENPPLEDGYVYVGSLKVQIIENLLRCPAEGCYKNFRNNTLLQMHIKHYHREMRKMLGATPKVLDLARKRTKPTSIEPPKPRYEPESKIIKVKLPRLPKRIIEETKIEIKPKKEESPSELHIDIPVAPTSKTNSPVPRSQDSPKLRQALANKPVKRPKVLLPVRRPDPEPIVEKEIEIPTLDYEEVATENEFERPTESLDFESEISAHTVTKALDETRKKSEKKRKCFSTISKKPMSEEDEWYGGNSDVDTRSSCPGSGTPDSKTMDKAMTQQAVSSESNNEDQKENSTYIYTETGERVKIERMKREEIISCHCGFREEDGLMVQCELCLCWQHALCHNIQKESEVPDKYTCSICLNPRRGRRSKRFLHDQDRLYEGLLPGAKPCESLRRSHELSGNLLRIQDALHALRVKYYVATKKDHPKLYLWAKDWENAEVTLTQERLTSDYSDLSIMLNNIGKENLPVKPEEVKDGHLDIRTPIIDDPDQDRFTQSSNSLLTLTTALSSPSGGPSLDLPITTSELERLAKSVQEQEVPRNVMVPQPEAAIENGACRERLLRHVQRCQALIDARLDSFEAQVAELESQDPSFEDDETADYFPRTKQTIQMLMRDLDTMEELGIIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2