Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.18 2.2e+03 -1.9 0.6 238 238 72 72 10 119 0.55

2 3 7.9e-23 9.9e-19 68.2 12.9 1 97 130 224 130 228 0.81

3 3 0.4 5e+03 -3.1 9.7 3 45 210 253 208 271 0.61

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.18	2.2e+03	-1.9	0.6	238	238	72	72	10	119	0.55
2	3	7.9e-23	9.9e-19	68.2	12.9	1	97	130	224	130	228	0.81
3	3	0.4	5e+03	-3.1	9.7	3	45	210	253	208	271	0.61

Coding Sequence: ATGGGTGAGCGGTCTGACCTAGCAACATCAGAGAACAGCGACGAGGAGAGCGGTGAGGCCTTCACTGATGGTGATTTTGAAGATTCAGATGATGAGACGGTCATCGAACGTAGTGCTTCCAGTAAAACGGCAAATATCCCTCTCAACGAAAGTGTgaattctaatattaaaattgacagTACTATTGATGAAACAGATGACACTTTAGAGGAACACATCAACGGTCACACGGAGAAGCTTAACAGCTGTGACGGCGatgatgataaaaatgtaaaaataaataataatcagaggAACGGTGATAATTCGTTAGAAGATTTGGAAATAGATTCGCAGAGCGATAGCAATGGGTCTATCGTTGGAATACTCGGAGATCAACAAAGTCACGCGGAACAACGGCTGGCTGCTCGACGAGCGGCGCGGGCGGAGGCGCGAGAGATACGGATGAGGGAGCTCGAGCGACAGCAGCGCGAGCAGGAGGACCATGCCGACAAGGCGTATGACATGTACGCAGGCGTACTGCCTATTACAGAGACAGTGGGGCGGCGGGCGGGCGGGCGCCTGGCGGCCATGAGCCCGAGCGCGCTGCACTCGCCGCGCCGCAGCTCGGAGGACTCGGACGACGTGGCCCGCCTGCGCGCGCGCCAGGACCACCAGGACGAGCACGAGGAGCTGCTCAAGCAGGAGCGCCGCCGCCTGCAGCGCGAGGCGCGGGAAGCATTAAACCGAGTTGAGGAATTGGAAACGGAGAACAGTCACCTCACGAAACGGCTCGACAAACTCAAGAACGCGAAGTCCGCCCTCCTGAAGGACCTGTGA
Protein Sequence: MGERSDLATSENSDEESGEAFTDGDFEDSDDETVIERSASSKTANIPLNESVNSNIKIDSTIDETDDTLEEHINGHTEKLNSCDGDDDKNVKINNNQRNGDNSLEDLEIDSQSDSNGSIVGILGDQQSHAEQRLAARRAARAEAREIRMRELERQQREQEDHADKAYDMYAGVLPITETVGRRAGGRLAAMSPSALHSPRRSSEDSDDVARLRARQDHQDEHEELLKQERRRLQREAREALNRVEELETENSHLTKRLDKLKNAKSALLKDL*

Sequence clustering based on sequence similarity using MMseqs2