g10105.t1
Basic Information
- Insect
- Nymphalis c-album
- Gene Symbol
- PAX6
- Assembly
- GCA_905332345.1
- Location
- CAJOBY010000017.1:6690776-6696070[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 3.6e-69 6.9e-66 220.3 0.2 1 117 31 147 31 152 0.98
Sequence Information
- Coding Sequence
- ATGCTGCCGGCGCAGCAGCTAGCGCCGATAAGCCCGTGGCCACCCGATGCGATGCTGGACCGCATGGACGACCTGGCGCACAAAGGTAAAGGGCACAGCGGTGTTAACCAGCTCGGCGGCGTGTTTGTAGGAGGCAGACCATTGCCCGACTCCACGAGGCAGAAGATCGTGGAGCTCGCTCACTCGGGAGCAAGGCCCTGCGATATTAGCCGCATCCTGCAGGTCTCAAATGGCTGCGTGTCGAAGATACTTGGCAGgTATTATGAAACGGGTTCTATACGACCTCGGGCTATCGGCGGGTCGAAGCCACGAGTGGCCACCGCAGAAGTGGTGAGCAAGATTGCGCAATACAAGCGAGAGTGCCCGTCAATCTTCGCGTGGGAGATCAGAGACCGTCTTCTGAGTGAAGGAGTCTGCACATCGGATAACATTCCTAGCGGTGCTATAACGCCTTATCTTCCCCAGCACTATACAGGACTCCCCTTTCCTTTCCCCTTCTCCTCCCCCTACCGTGGCAAAACAATATGA
- Protein Sequence
- MLPAQQLAPISPWPPDAMLDRMDDLAHKGKGHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTSDNIPSGAITPYLPQHYTGLPFPFPFSSPYRGKTI*
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01079861; iTF_01078174; iTF_00358531; iTF_00353031; iTF_00205089; iTF_00986023; iTF_00354045; iTF_00155264; iTF_00659410; iTF_00710983; iTF_00896777; iTF_00418955; iTF_00715758; iTF_01507184; iTF_00775987; iTF_00778722; iTF_00777972; iTF_00801817; iTF_00780218; iTF_00433116; iTF_00159805; iTF_00723030; iTF_00843501; iTF_01181856;
- 90% Identity
- iTF_00354045;
- 80% Identity
- iTF_01021175;