Nudd018436.1
Basic Information
- Insect
- Notocelia uddmanniana
- Gene Symbol
- KEAP1
- Assembly
- GCA_905163555.1
- Location
- LR991058.1:8879200-8923874[+]
Transcription Factor Domain
- TF Family
- BTB
- Domain
- zf-C2H2|ZBTB
- PFAM
- PF00651
- TF Group
- Zinc-Coordinating Group
- Description
- The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 4 6.8e-12 4.3e-09 38.1 0.1 4 44 115 154 112 159 0.91 2 4 3.3e-10 2.1e-07 32.7 0.1 5 44 154 192 152 196 0.88 3 4 2.8e-10 1.8e-07 32.9 0.1 5 44 192 230 190 236 0.91 4 4 2.6e-28 1.6e-25 91.0 0.0 10 109 235 332 229 333 0.94
Sequence Information
- Coding Sequence
- ATGGAGGAGGCGGGGCGCAGCAACCTGCTGGACGATATGCCTCCATTCAACTACGAGGCGACGCTGCAGGGCGACGTGGGCGCAGGCTGCAACGACGTTGGCGACATGACCTTTTGCATGGGGAACTACATATCCGACTTCATGAAGACTGTTCAACTGCAGACGAAGTTGCACAGCGTCTTGGGCGCCGGCAGCGACATTAACTTCTGCATAGGCAACTACGTCTCCGACTTCATGAAGACGAAGTTGCAGAGCAACGTGGGCGCAAGCTGCTACGACGTCAGGGCCATTGCCTTATGCATGGACAACTACATCTACGTCTTAATGAAGATGATGTTCACTATGCGCTCGCACCACATGCTCACGGACGTAGTGCTGGAGGTGGGCAGCGAGCTGTTCCACGTGCACAAGGTCGTGCTGGCAGCCGGCAGCCCCTACTTCAAGGTGATCTTCACGACGCGCTCGCCCCACATGATCACGGACGTGGTGCTGGAGGTGGGCAGCGAGCTGTTCCACGTGCACAAGGTCGTGCTGACCGCCGGCAGCCCCTACTTCAAGGTGATCTTCACGACGCGCTCGCACCACATGCTCACGGACGTGGTGCTGGAGGTGGGCAGCGAGCTGTTCCACGTGCACAAGGTCGTGCTGGCCACCGGCAGCCCCTTCTTCAAGGTGATCTTCACGACGCGCTCGCACCTCATGATCACGGACGTGGTGCTGGAGGTGGGCAGCGAGCTGTTCCACGTGCACAAGGTTGCGCTGGCCGCCGGCAGCCCCTATTTCAAGGCGATGTTCACAAGCGGACTGAAGGAGTGCGAGATGTCGCGCGTGCGTCTGCAGGGCGTGTGTCCGTCGGCCATGGCGTGGCTCGTCTACTTCATGTACACGGGCAAGGTCCGCATCACGGAGGTCACCGTTTGTCAGCTGCTGCCCGCCGCCACCATGTTCCAGATATCGAACGTGATAGAGGCGTGCTGCGCGTTCCTGGAGCGGCAGCTGGGGCCCTCGAACGCGATCGGCATCGCCAACTTCGCGGAACAGCACGGCTGCGTCGAACTCAAGCAGAAGGCCAACCAGTTCATAGAGAGGCACTTCACTGAGGTGTGTCAAGAGGAAGAATTCCTACAACTAACGCCCTCGGAGCTGATATCGCTGGTGCGGAAAGATGAGCTTAACGTTCGGGAAGAATGCGAGGTCTACAATGCCGTCCTTAGCTGGGTGAAATACGATGAGGACCGACGACACCCGCGCATGGAACACATCCTCCAGGCGGTCCGCTGCCAATACCTCACGCCCAGCTTCCTCAAAGAGCAGATGCGCTCTTGCTCCGTGCTGCAGAAAGTGCCCGCTTGTCGCGAGTACCTCGCGAGGATATTCCAGgatctGACGTTACACAAAAAGCCGGTGGTAAAGGAGCGGCGGCCGAACACGCCGCGCATCATCTACGTGGCGGGCGGGTACTTCCGACACTCCATTGACGTGTTTGAGGCCTTTAACCTGGATGATGGCTGCTGGACCAATCTCCCTCGCCTCACCGTGCCACGCTCGGGGCTCGGCGCGGCCTTCCTCAAGGGTCTGTTCTACGCGGTGGGCGGGCGCAACACGTCTCCCGGCTCGTCGTACGACAGCGACTGGGTGGATGTGTACAACCCCGCCAACGAGCACTGGCGGCCCTGCAGCCCCATGTCCACGCCCCGGCATAGGGTGGGAGTAGCAGTAATGGATGGATTGTTATACGCGGTCGGTGGCTCGGCGGGGTCGGAGTACCACAAGTCCGTAGAATGCTACGACCCCGAGAAGGACTTGTGGTCGACGGTGGCGCCGATGGCGTCGGCGCGGCTGGGCGTGGGCGCGGCCGTGGTGAACCGGCTGCTGTACGCGGTGGGCGGCTTCGACGGCGCGCGCCGCGTCAACACCGCCGAGTGCTACCACCCCGAGAACAACCGCTGGTCCGCCATCGCGCCCATGCAGCAGGCGCGCAGCGGCGCCGGGGTAGCCGCGCTAGGCCAGTACATCTACGTGGTGGGCGGGTACGACGGGTCGCAGCAGCTGGCCTCGGTGGAGCGCTACGACACGGAGCGCGACGTGTGGGAGCCCGCGGCGCCCGTGCGCATCGCGCGCTCCGCGCTCTCGCTCACCGTGCTCGACAACAAGCTCTACGCCATGGGCGGCTACGACGGCACATCATTCCTGGACATAGTGGAGGTGTACGACCCGGTGACGAACGTGTGGTCGCCGGGCACGGCGCTCACGTCGCTGCGCTCGGGGCACGCGTCGGCCGTGTGCTACCAGCACGTGGCCAGCGCCGACCTCGAGCCCGAGCCCGCGCGCAAGCGCCCCGCCCCCGCCCAGGACATCCCCATGGCCAACAACATCATAGGCACCTTATCCAATAACAACTGTCGAGGGTGCTTATAG
- Protein Sequence
- MEEAGRSNLLDDMPPFNYEATLQGDVGAGCNDVGDMTFCMGNYISDFMKTVQLQTKLHSVLGAGSDINFCIGNYVSDFMKTKLQSNVGASCYDVRAIALCMDNYIYVLMKMMFTMRSHHMLTDVVLEVGSELFHVHKVVLAAGSPYFKVIFTTRSPHMITDVVLEVGSELFHVHKVVLTAGSPYFKVIFTTRSHHMLTDVVLEVGSELFHVHKVVLATGSPFFKVIFTTRSHLMITDVVLEVGSELFHVHKVALAAGSPYFKAMFTSGLKECEMSRVRLQGVCPSAMAWLVYFMYTGKVRITEVTVCQLLPAATMFQISNVIEACCAFLERQLGPSNAIGIANFAEQHGCVELKQKANQFIERHFTEVCQEEEFLQLTPSELISLVRKDELNVREECEVYNAVLSWVKYDEDRRHPRMEHILQAVRCQYLTPSFLKEQMRSCSVLQKVPACREYLARIFQDLTLHKKPVVKERRPNTPRIIYVAGGYFRHSIDVFEAFNLDDGCWTNLPRLTVPRSGLGAAFLKGLFYAVGGRNTSPGSSYDSDWVDVYNPANEHWRPCSPMSTPRHRVGVAVMDGLLYAVGGSAGSEYHKSVECYDPEKDLWSTVAPMASARLGVGAAVVNRLLYAVGGFDGARRVNTAECYHPENNRWSAIAPMQQARSGAGVAALGQYIYVVGGYDGSQQLASVERYDTERDVWEPAAPVRIARSALSLTVLDNKLYAMGGYDGTSFLDIVEVYDPVTNVWSPGTALTSLRSGHASAVCYQHVASADLEPEPARKRPAPAQDIPMANNIIGTLSNNNCRGCL*
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -