Nnoc021137.1
Basic Information
- Insect
- Nomophila noctuella
- Gene Symbol
- SHR2
- Assembly
- GCA_958496325.1
- Location
- OY292506.1:1206438-1221335[-]
Transcription Factor Domain
- TF Family
- THR-like
- Domain
- zf-C4|THR-like
- PFAM
- AnimalTFDB
- TF Group
- Zinc-Coordinating Group
- Description
- DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. TR interacts with the thyroid response element, which is a DNA site with direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to five base pairs, upstream of target genes and modulates the rate of transcriptional initiation. Thyroid hormone receptor (TR) mediates the actions of thyroid hormones, which play critical roles in growth, development, and homeostasis in mammals. They regulate overall metabolic rate, cholesterol and triglyceride levels, and heart rate, and affect mood. TRs are expressed from two separate genes (alpha and beta) in human and each gene generates two isoforms of the receptor through differential promoter usage or splicing. TRalpha functions in the heart to regulate heart rate and rhythm and TRbeta is active in the liver and other tissues. The unliganded TRs function as transcription repressors, by binding to thyroid hormone response elements (TRE) predominantly as homodimers, or as heterodimers with retinoid X-receptors (RXR), and being associated with a complex of proteins containing corepressor proteins. Ligand binding promotes corepressor dissociation and binding of a coactivator to activate transcription. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, TR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [4, 3, 5, 2, 7, 1, 6]
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 15 4.7e-05 0.052 13.7 0.0 28 127 286 408 281 412 0.76 2 15 0.03 33 4.5 0.0 97 124 437 464 431 470 0.92 3 15 0.031 34 4.5 0.0 97 124 474 501 468 505 0.92 4 15 0.028 31 4.6 0.0 97 124 511 538 505 546 0.91 5 15 0.028 31 4.6 0.0 97 124 548 575 542 583 0.91 6 15 0.029 32 4.6 0.0 97 124 585 612 580 620 0.91 7 15 0.028 31 4.6 0.0 97 124 622 649 616 657 0.91 8 15 0.03 33 4.5 0.0 97 124 659 686 653 692 0.92 9 15 0.028 31 4.6 0.0 97 124 696 723 690 731 0.91 10 15 0.03 33 4.5 0.0 97 124 733 760 727 766 0.92 11 15 0.027 30 4.6 0.0 97 124 770 797 763 806 0.91 12 15 0.032 35 4.4 0.0 97 124 807 834 801 837 0.92 13 15 0.03 33 4.5 0.0 97 124 844 871 838 877 0.92 14 15 0.026 29 4.7 0.0 97 124 881 908 875 919 0.90 15 15 0.0086 9.6 6.3 0.0 97 127 918 948 911 949 0.91
Sequence Information
- Coding Sequence
- ATGGACGGCCAGGACCAAATGGACTTAAAATACAGTGGAGGAGCAGAAGTAGGAGGCCTAGAGCTGTGCATTGTTTGTGGAGACCGGGCCTCTGGCAGACATTATGGTGCTATCAGTTGTGAAGGTTGTAAAGGGTTTTTCAAACGTTCCATACGCAAGAAGCTGGGCTACCAGTGCCGTGGGAGTATGAACTGCGAAGTGACTAAGCACCACCGCAACCGCTGTCAATATTGTCGTTTGCAGAAGTGCCTCGCTTGCGGAATGAGGAGTGACTCGGTCCAGCACGAACGCAAACCGATAGTGGACAAGTCGAAGGGCGAGGCGCGGGAGGGACACGACCGGCAGGCGGCCTACTCTAAGCTGCTCGGCTTGGCCGGGCAGGCACAGTGTGCTCAGATCAATCCGAAGGAGGAGCCGAGCGACGCGTTCGGCGCGGTGTCGCCGGCCGCGCCCGCCATCAACttcgcgctcgccgccgccgtcgcgtTCAACAAGGGGAACCCAGTTTCTCCGTACTTAAACGCGGGCGCGAGCGACATTGAAGGCGCGCGCCGGCAGCAACTGATGCTGCAGACTCAGCTTGCGAAAAACCTCTTCAAGATGGGACAGTTCGGTGCTATAAACGAGTACCTCCAATCCGCGTACGGAGCTACGCCGCCCGACGTGCCGCTGTCCCTGCACGCGGCGGCCGACACACAACAGACTGAAAACGACGCGGACTCGAACATCCTGAGCACGGCGGAGTCGCTGCAGCTGGTGGTGTCGCTGCCGGGCCCCGCGCCGGCGCAGCTGCGGCTGCACGCGGCGTgcgaggcgggcgcgcgcctgctggccgcctgcgcgcgctggcTGCGACACGTGCCGCACGCCGCCCGCCTGCCGTTCGAGATCCAAGTGACATTGCTGAAGAAGTGCTGGCCGGAGCTGTTTGTCCTCGGCCTCGCAATGTACTCTGGCGCGATGGGCCTCCCGTCACTATTGCCGCTGCTGGTCACCCATCTGCAGTGCGTGCTGCGAGAGAGGGCCAGCGAGTCACTTGATAGATCCGTGGAACTAGACCAGCCAGAGATAACGACTGCGGACTACTCGGACGAGCGGATCGCCGAGATCAGCGGCATGCTGACGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGCTGCGCGTCACCGAGCGCGAGTACGCGCATCTAAGAGCACTGTGTCTGTTCTCGCCAGGTGAGAGACTgaccaatctgCCCTTCGACAACTTTGTTGTCCTAACGAAGAATGGAATAAGTCTAGTTGCTTTATATCTGGCTCCGCGGCTGCAGCAGTTCGTCGGCAGCATGGAGCAGCTGCGCGTCACCGAGCGCGAGTACGCGCATCTTAGAGCGCTGTGCCTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGGTGAGAGACTGTGA
- Protein Sequence
- MDGQDQMDLKYSGGAEVGGLELCIVCGDRASGRHYGAISCEGCKGFFKRSIRKKLGYQCRGSMNCEVTKHHRNRCQYCRLQKCLACGMRSDSVQHERKPIVDKSKGEAREGHDRQAAYSKLLGLAGQAQCAQINPKEEPSDAFGAVSPAAPAINFALAAAVAFNKGNPVSPYLNAGASDIEGARRQQLMLQTQLAKNLFKMGQFGAINEYLQSAYGATPPDVPLSLHAAADTQQTENDADSNILSTAESLQLVVSLPGPAPAQLRLHAACEAGARLLAACARWLRHVPHAARLPFEIQVTLLKKCWPELFVLGLAMYSGAMGLPSLLPLLVTHLQCVLRERASESLDRSVELDQPEITTADYSDERIAEISGMLTRLQQFVGSMEQLRVTEREYAHLRALCLFSPGERLTNLPFDNFVVLTKNGISLVALYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPGERL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01071680;
- 90% Identity
- iTF_01071680;
- 80% Identity
- iTF_01071680;