Nnoc021137.1
Basic Information
- Insect
- Nomophila noctuella
- Gene Symbol
- SHR2
- Assembly
- GCA_958496325.1
- Location
- OY292506.1:1206438-1221335[-]
Transcription Factor Domain
- TF Family
- RXR-like
- Domain
- zf-C4|RXR-like
- PFAM
- AnimalTFDB
- TF Group
- Zinc-Coordinating Group
- Description
- DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. RXR functions as a DNA binding partner by forming heterodimers with other nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR. All RXR heterodimers preferentially bind response elements composed of direct repeats of two AGGTCA sites with a 1-5 bp spacer. RXRs can play different roles in these heterodimers. RXR acts either as a structural component of the heterodimer complex, required for DNA binding but not acting as a receptor, or as both a structural and a functional component of the heterodimer, allowing 9-cis RA to signal through the corresponding heterodimer. In addition, RXR can also form homodimers, functioning as a receptor for 9-cis RA, independently of other nuclear receptors. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, RXR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [cite:PUB00121610], [cite:PUB00121611], [cite:PUB00121612], [cite:PUB00025660], [cite:PUB00121613], [cite:PUB00092048], [cite:PUB00092725], [cite:PUB00092726], [cite:PUB00016724], [cite:PUB00059514PMID:18971932
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 15 4.8e-22 1.1e-18 68.4 0.0 2 115 270 405 269 414 0.81 2 15 4.4e-06 0.01 16.3 0.0 86 115 435 464 425 471 0.94 3 15 4.8e-06 0.011 16.1 0.0 86 115 472 501 467 508 0.94 4 15 5.3e-06 0.012 16.0 0.0 86 115 509 538 505 542 0.95 5 15 5.1e-06 0.012 16.1 0.0 86 115 546 575 543 581 0.94 6 15 4.8e-06 0.011 16.1 0.0 86 115 583 612 578 619 0.94 7 15 4.9e-06 0.011 16.1 0.0 86 115 620 649 615 655 0.94 8 15 5.1e-06 0.012 16.1 0.0 86 115 657 686 654 692 0.94 9 15 5e-06 0.011 16.1 0.0 86 115 694 723 690 729 0.94 10 15 4.8e-06 0.011 16.1 0.0 86 115 731 760 726 767 0.94 11 15 5.1e-06 0.012 16.1 0.0 86 115 768 797 765 803 0.94 12 15 4.9e-06 0.011 16.1 0.0 86 115 805 834 800 840 0.94 13 15 5e-06 0.011 16.1 0.0 86 115 842 871 839 878 0.94 14 15 4.8e-06 0.011 16.1 0.0 86 115 879 908 874 915 0.94 15 15 5.6e-06 0.013 15.9 0.0 86 115 916 945 912 948 0.94
Sequence Information
- Coding Sequence
- ATGGACGGCCAGGACCAAATGGACTTAAAATACAGTGGAGGAGCAGAAGTAGGAGGCCTAGAGCTGTGCATTGTTTGTGGAGACCGGGCCTCTGGCAGACATTATGGTGCTATCAGTTGTGAAGGTTGTAAAGGGTTTTTCAAACGTTCCATACGCAAGAAGCTGGGCTACCAGTGCCGTGGGAGTATGAACTGCGAAGTGACTAAGCACCACCGCAACCGCTGTCAATATTGTCGTTTGCAGAAGTGCCTCGCTTGCGGAATGAGGAGTGACTCGGTCCAGCACGAACGCAAACCGATAGTGGACAAGTCGAAGGGCGAGGCGCGGGAGGGACACGACCGGCAGGCGGCCTACTCTAAGCTGCTCGGCTTGGCCGGGCAGGCACAGTGTGCTCAGATCAATCCGAAGGAGGAGCCGAGCGACGCGTTCGGCGCGGTGTCGCCGGCCGCGCCCGCCATCAACttcgcgctcgccgccgccgtcgcgtTCAACAAGGGGAACCCAGTTTCTCCGTACTTAAACGCGGGCGCGAGCGACATTGAAGGCGCGCGCCGGCAGCAACTGATGCTGCAGACTCAGCTTGCGAAAAACCTCTTCAAGATGGGACAGTTCGGTGCTATAAACGAGTACCTCCAATCCGCGTACGGAGCTACGCCGCCCGACGTGCCGCTGTCCCTGCACGCGGCGGCCGACACACAACAGACTGAAAACGACGCGGACTCGAACATCCTGAGCACGGCGGAGTCGCTGCAGCTGGTGGTGTCGCTGCCGGGCCCCGCGCCGGCGCAGCTGCGGCTGCACGCGGCGTgcgaggcgggcgcgcgcctgctggccgcctgcgcgcgctggcTGCGACACGTGCCGCACGCCGCCCGCCTGCCGTTCGAGATCCAAGTGACATTGCTGAAGAAGTGCTGGCCGGAGCTGTTTGTCCTCGGCCTCGCAATGTACTCTGGCGCGATGGGCCTCCCGTCACTATTGCCGCTGCTGGTCACCCATCTGCAGTGCGTGCTGCGAGAGAGGGCCAGCGAGTCACTTGATAGATCCGTGGAACTAGACCAGCCAGAGATAACGACTGCGGACTACTCGGACGAGCGGATCGCCGAGATCAGCGGCATGCTGACGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGCTGCGCGTCACCGAGCGCGAGTACGCGCATCTAAGAGCACTGTGTCTGTTCTCGCCAGGTGAGAGACTgaccaatctgCCCTTCGACAACTTTGTTGTCCTAACGAAGAATGGAATAAGTCTAGTTGCTTTATATCTGGCTCCGCGGCTGCAGCAGTTCGTCGGCAGCATGGAGCAGCTGCGCGTCACCGAGCGCGAGTACGCGCATCTTAGAGCGCTGTGCCTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGTTCCGTTATATCTGGCTCCGCGGCTTCAGCAGTTCGTCGGCAGCATGGAGCAGTTGCGCGTCACCGAGCGCGAGTACGCGCATCTGAGAGCGCTGTGCTTGTTCTCGCCAGGTGAGAGACTGTGA
- Protein Sequence
- MDGQDQMDLKYSGGAEVGGLELCIVCGDRASGRHYGAISCEGCKGFFKRSIRKKLGYQCRGSMNCEVTKHHRNRCQYCRLQKCLACGMRSDSVQHERKPIVDKSKGEAREGHDRQAAYSKLLGLAGQAQCAQINPKEEPSDAFGAVSPAAPAINFALAAAVAFNKGNPVSPYLNAGASDIEGARRQQLMLQTQLAKNLFKMGQFGAINEYLQSAYGATPPDVPLSLHAAADTQQTENDADSNILSTAESLQLVVSLPGPAPAQLRLHAACEAGARLLAACARWLRHVPHAARLPFEIQVTLLKKCWPELFVLGLAMYSGAMGLPSLLPLLVTHLQCVLRERASESLDRSVELDQPEITTADYSDERIAEISGMLTRLQQFVGSMEQLRVTEREYAHLRALCLFSPGERLTNLPFDNFVVLTKNGISLVALYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPVPLYLAPRLQQFVGSMEQLRVTEREYAHLRALCLFSPGERL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01071715;
- 90% Identity
- iTF_01071715;
- 80% Identity
- iTF_01071715;