Nnoc014059.1
Basic Information
- Insect
- Nomophila noctuella
- Gene Symbol
- Foxn3
- Assembly
- GCA_958496325.1
- Location
- OY292496.1:10381262-10383461[+]
Transcription Factor Domain
- TF Family
- Fork_head
- Domain
- Fork_head domain
- PFAM
- PF00250
- TF Group
- Helix-turn-helix
- Description
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 5 3.7e-23 4.9e-20 72.0 0.0 13 64 1 51 1 55 0.97 2 5 3.8e-30 5e-27 94.4 0.1 2 64 61 122 60 126 0.97 3 5 9.5e-28 1.2e-24 86.8 0.1 4 64 132 191 131 195 0.97 4 5 1.3e-29 1.7e-26 92.7 0.2 2 64 200 261 199 265 0.97 5 5 2.6e-35 3.5e-32 111.0 0.0 2 85 271 352 270 355 0.95
Sequence Information
- Coding Sequence
- ATGGCGATAGAGGCGGCACCCGCTCGAGCCCTCCCCGTCAAGGAGATCTACGCGTGGATAGTGCGGCACTTCCCGTACTTCAAGCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATAAGGTAATTCAACTAGTAGACGTCATTCTCACCAAGCCGCCCTACTCCTTCTCCTGCCTCATCTTCATGGCCATAGAGGCGGCACCAGCTCGAGCCCTCCCAGTGAAGGAGATCTACGCGTGGATAGTTCGGCACTTCCCGTACTTCAAGCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATAAGGTAATTGAACCAATAGTAGTCATTTATTGCAACTACTCCTTCTCCTGCCTCATCTTCATGGCGATAGAGGCAGCACCCGCCCGTGCCCTCCCAGTCAAGGAGATCTACGCGTGGATAGTCCGCCACTTTCCCTACTTCAAGCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATAAGGTAATTCAACTAGTAGACGTCATTATCAAGCCGCAATACTCCTTCTCCTGCCTCATCTTCATGGCGATAGAGGCGGCACCCGCTCGAGCCCTCCCCGTCAAGGAGATCTACGCCTGGATAGTCCGCCACTTCCCCTACTTCAAGCACGCGCCTCAGGGCTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATAAGGTAATTCAACTAGTAGACGTCATTCTCACCAAGCCGCCCTACTCCTTCTCCTGCCTCATCTTCATGGCGATCGAGGCGGCACCAGCTCGAGCCCTCCCGGTGAAGGAGATCTACGCGTGGATAGTGCGGCACTTCCCGTACTTCAAGCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATAAGGTGGCAGCGGCCCCGGGTCTGGGGAAAGGCTCGCTTTGGACAGTGGATCCCCAGCACCGAGCGTCATTATTACAGGCGTTCGGCCGTCAGCCGatcccgcccgcgccgccggaCACGCCGCCGCCGGCCAAGAACGCGCCGGACCCGCAGCTGTTCCCGTTCCTGGCGCGGCGCCTggccgcctcgccgccgccgccgcagcccggCGCCGACGAGTACCTCGCCGCCGCCACCGTGCTCGCCATGAAGTACGGGCCCGCCGTGCTCGACCAGCTCCCCCCGGCGGCGCACCTGGTGATATCCCGGTGCGCGCGCGACGAGCACTCGTACAGCGGCGGCTGCGAGGAGCGCCGCACGGCCGAGGCGCTGCTCAACCTGGCCGGCgtgcccgcgccgcccgcgcactccagctag
- Protein Sequence
- MAIEAAPARALPVKEIYAWIVRHFPYFKHAPQGWKNSVRHNLSLNKCFHKVIQLVDVILTKPPYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFKHAPQGWKNSVRHNLSLNKCFHKVIEPIVVIYCNYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFKHAPQGWKNSVRHNLSLNKCFHKVIQLVDVIIKPQYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFKHAPQGWKNSVRHNLSLNKCFHKVIQLVDVILTKPPYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFKHAPQGWKNSVRHNLSLNKCFHKVAAAPGLGKGSLWTVDPQHRASLLQAFGRQPIPPAPPDTPPPAKNAPDPQLFPFLARRLAASPPPPQPGADEYLAAATVLAMKYGPAVLDQLPPAAHLVISRCARDEHSYSGGCEERRTAEALLNLAGVPAPPAHSS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -