Basic Information

Gene Symbol
foxn3
Assembly
GCA_958496325.1
Location
OY292496.1:10371515-10380799[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 5e-30 6.6e-27 94.1 0.1 2 66 161 224 160 229 0.96
2 13 6.8e-29 8.9e-26 90.4 0.2 2 64 232 293 231 295 0.98
3 13 1.1e-29 1.5e-26 93.0 0.1 2 64 303 364 302 369 0.97
4 13 5.2e-26 6.9e-23 81.2 0.1 6 64 376 433 374 437 0.95
5 13 2.4e-27 3.1e-24 85.5 0.1 4 64 443 502 442 507 0.96
6 13 1.3e-29 1.7e-26 92.7 0.1 2 64 512 573 511 577 0.97
7 13 5e-30 6.6e-27 94.1 0.1 2 66 583 646 582 651 0.96
8 13 6.8e-29 8.9e-26 90.4 0.2 2 64 654 715 653 717 0.98
9 13 1.1e-29 1.5e-26 93.0 0.1 2 64 725 786 724 791 0.97
10 13 5.2e-26 6.9e-23 81.2 0.1 6 64 798 855 796 859 0.95
11 13 2.4e-27 3.1e-24 85.5 0.1 4 64 865 924 864 929 0.96
12 13 1.3e-29 1.7e-26 92.7 0.1 2 64 934 995 933 999 0.97
13 13 4e-28 5.3e-25 87.9 0.1 2 61 1005 1063 1004 1064 0.98

Sequence Information

Coding Sequence
ATGGCGCCAATGCGTGGAGAGCGTGGTGGGTCACCGGCTCGCGGGGCGCGGCCATCCCTGCCGCTGCCACGGCGGCTGATCCGCCAGATCGCGAGGCACGTCGCCTCCAGCGGCCGGTCGTTGCGGAGGCTCGAGGTCTCGGGAAGAGTTATAGACAACTTCGATGACATAGATGACGCGTCGGACGAGTCGGATCTTGAAGTACCACAGCCCGCAGTCGCCTGCGGTGGGAATGCAGGCAACCTGCCCCCAGCAGACCACGATGACGACCTCACAAGCCTGAGTTGGCTGCAAGACAGAAATCTACTGAGagGAATAAACCTAACAAAAAGTGATATGGAAGACCCTAAAATAATCGCGAGTCAAGTCGTGATAAAGTCAGAGCCGTCGAAGACGCCTCCGCCGGTCGTGCGCATCCCGTCCCCGCCGCGCACGCCGTGCAAGGCGCCGCCCTCCCCGCCCGCCGTCGCCGCGCACACCAAGCCGCCCTACTCCTTCTCCTGCCTCATCTTCATGGCCATCGAGGCGGCGCCAGCTCGAGCCCTCCCAGTGAAGGAGATCTACGCGTGGATAGTCCGCCACTTCCCGTACTTCAAGCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATAAGGTAACTCAACTAGTAGCAGCCACTCACACCAAGCCGCCCTACTCCTTCTCCTGCCTCATCTTCATGGCCATCGAGGCGGCGCCAGCTCGAGCCCTCCCAGTAAAGGAGATCTACGCGTGGATAGTCCGCCACTTCCCCTACTTCAAGCACGCGCCGCAGGACTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATAAGGTAATTCTACTAGTAGCAGTCACTCACACCAAGCCGCCCTACTCCTTCTCCTGCCTCATCTTCATGGCGATAGAGGCGGCACCAGCCCGAGCCCTCCCAGTCAAGGAAATCTACGCGTGGATAGTGCGGCACTTCCCGTACTTCAAGCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATAAGGTAATTCAACTAGGAGAAGTCATTTATTGCATCTACTTCTTCTCCTGCCTCATCTTCATGGCGATAGAGGCGGCGCCGGCCCGAGCCCTCCCAGTGAAGGAGATCTACGCGTGGATAGTGCGGCACTTCCCCTACTTCAAGCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATAAGGTAATTGAACCAATAGTAGTCATTTATTGCAACTACTCCTTCTCCTGCCTCATCTTCATGGCGATAGAGGCAGCACCAGCTCGAGCCCTCCCCGTCAAGGAGATCTACGCGTGGATAGTGCGACACTTCCCGTACTTCAAGCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATAAGGTAATTCAACTAGCAGGAGTCATTCTCACCAAGCCGCCCTACTCCTTCTCCTGCCTCATCTTCATGGCCATCGAGGCGGCACCCGCCCGTGCCCTCCCAGTGAAGGAGATCTACGCGTGGATAGTGCGGCACTTCCCGTACTTCAAGCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATAAGGTAATTCAACTAGTAGCAGTCACTCACACCAAGCCGCCCTACTCCTTCTCCTGCCTCATCTTCATGGCCATCGAGGCGGCGCCAGCTCGAGCCCTCCCAGTGAAGGAGATCTACGCGTGGATAGTCCGCCACTTCCCGTACTTCAAGCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATAAGGTAACTCAACTAGTAGCAGCCACTCACACCAAGCCGCCCTACTCCTTCTCCTGCCTCATCTTCATGGCCATCGAGGCGGCGCCAGCTCGAGCCCTCCCAGTAAAGGAGATCTACGCGTGGATAGTCCGCCACTTCCCCTACTTCAAGCACGCGCCGCAGGACTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATAAGGTAATTCTACTAGTAGCAGTCACTCACACCAAGCCGCCCTACTCCTTCTCCTGCCTCATCTTCATGGCGATAGAGGCGGCACCAGCCCGAGCCCTCCCAGTCAAGGAAATCTACGCGTGGATAGTGCGGCACTTCCCGTACTTCAAGCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATAAGGTAATTCAACTAGGAGAAGTCATTTATTGCATCTACTTCTTCTCCTGCCTCATCTTCATGGCGATAGAGGCGGCGCCGGCCCGAGCCCTCCCAGTGAAGGAGATCTACGCGTGGATAGTGCGGCACTTCCCCTACTTCAAGCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATAAGGTAATTGAACCAATAGTAGTCATTTATTGCAACTACTCCTTCTCCTGCCTCATCTTCATGGCGATAGAGGCAGCACCAGCTCGAGCCCTCCCCGTCAAGGAGATCTACGCGTGGATAGTGCGACACTTCCCGTACTTCAAGCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATAAGGTAATTCAACTAGCAGGAGTCATTCTCACCAAGCCGCCCTACTCCTTCTCCTGCCTCATCTTCATGGCCATCGAGGCGGCACCCGCCCGTGCCCTCCCAGTGAAGGAGATCTACGCGTGGATAGTGCGGCACTTCCCGTACTTCAAGCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATAAGGTAATTCAACTAGTAGCAGTCACTCACACCAAGCCGCCCTACTCCTTCTCCTGCCTCATCTTCATGGCGATAGAGGCGGCGCCCGCTCGAGCCCTCCCAGTCAAGGAGATCTACGCGTGGATAGTGCGGCACTTCCCGTACTTCAAGCACGCGCCGCAGGGCTGGAAGAACAGCGTGCGGCATAACCTGTCGCTGAACAAGTGCTTCCATTAG
Protein Sequence
MAPMRGERGGSPARGARPSLPLPRRLIRQIARHVASSGRSLRRLEVSGRVIDNFDDIDDASDESDLEVPQPAVACGGNAGNLPPADHDDDLTSLSWLQDRNLLRGINLTKSDMEDPKIIASQVVIKSEPSKTPPPVVRIPSPPRTPCKAPPSPPAVAAHTKPPYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFKHAPQGWKNSVRHNLSLNKCFHKVTQLVAATHTKPPYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFKHAPQDWKNSVRHNLSLNKCFHKVILLVAVTHTKPPYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFKHAPQGWKNSVRHNLSLNKCFHKVIQLGEVIYCIYFFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFKHAPQGWKNSVRHNLSLNKCFHKVIEPIVVIYCNYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFKHAPQGWKNSVRHNLSLNKCFHKVIQLAGVILTKPPYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFKHAPQGWKNSVRHNLSLNKCFHKVIQLVAVTHTKPPYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFKHAPQGWKNSVRHNLSLNKCFHKVTQLVAATHTKPPYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFKHAPQDWKNSVRHNLSLNKCFHKVILLVAVTHTKPPYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFKHAPQGWKNSVRHNLSLNKCFHKVIQLGEVIYCIYFFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFKHAPQGWKNSVRHNLSLNKCFHKVIEPIVVIYCNYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFKHAPQGWKNSVRHNLSLNKCFHKVIQLAGVILTKPPYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFKHAPQGWKNSVRHNLSLNKCFHKVIQLVAVTHTKPPYSFSCLIFMAIEAAPARALPVKEIYAWIVRHFPYFKHAPQGWKNSVRHNLSLNKCFH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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