Njan011899.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Noctua janthina
Gene Symbol
-
Assembly
GCA_963576755.1
Location
OY755061.1:15087777-15088872[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.3e-09 1.7e-06 28.7 0.1 24 70 9 55 4 76 0.90

Sequence Information

Coding Sequence
ATGGATACTACACCTACAGAAGCAGCACAAATCGTCGCCCTATTGCAAGAAGGGCTCAGCCAGCGGGCTGTCGCACGTCAGCTCCACATAAGCCAGTCCTGTGTTTCGAAAATTTATAAACGCTTTCGGGAGACTGGTGGCTTTATCCCGAGACCAAGATCTGGACGGCGCCGGTGCACATCGGAGAGGGATGACCGTTTTATCGTGTCAACCTCTCTCCGAAATCGACATATGACTGGTGTCGACGTCCAACCTGTTGGACCTACCCCACGAACATTTCGGAGCTCAGGAGCTCCCAGCGAGTGGACAGTTCTTCGAAGACTTAAGCAAGCTAATTTGACTCCAAAAAGGCCTGCCACAGGCCCGAAACTGACGGCAGGTCACCGACAAGCACGCCTTCAATTTGCTCGCTTCCATCTTGATTGGGAGGTTGAGCAATGGAGGCGAGTTCTGTTCTCCGACGAGTGCAGAATGTGTTTGCACGGCAGCGATCGAAGGGGTCGGGTCTACAGGCGGCCTGGGGAGCGATTTGCGCAGTGCTGTTTCGCTGAGACAGTGGCTTATGGGGGCGGTTCTTGTATGATGTGGGCCGGCATTTCCTTCGACGGTAAAACGGAGCTTGTTTTCGTGCCTGGCGGGGGACGAGGAGGCGGTCTAACTTCAGACCGCTACATTTCCGATATTCTGCTGGAACATGTCGTTCCTTATGCGGGATATATCGGTGATGACTTCCTCCTTATGCACGATAACGCTCGTTATCACACTTCCCGTGCCACAACTCGGCCACATTGGACTGGCCCGGACTTGAAACCCATTGAGCACGTGTGGGATGAACTGAAGAGGAGGGTTCGTTCCAGAAATCCTGCTCCTTCAAGTGTAAATGAGCTGAAATTGGCTTTGATAGAAGAGTGGGAAGGTATCCCGCAAGAATCGGTTCGGAAGCTGATTAGGTCAATGAAGAACCGTCTTCGAGCAGTAATTAGGGCGAGGGGAGGGaacacaaaatattga
Protein Sequence
MDTTPTEAAQIVALLQEGLSQRAVARQLHISQSCVSKIYKRFRETGGFIPRPRSGRRRCTSERDDRFIVSTSLRNRHMTGVDVQPVGPTPRTFRSSGAPSEWTVLRRLKQANLTPKRPATGPKLTAGHRQARLQFARFHLDWEVEQWRRVLFSDECRMCLHGSDRRGRVYRRPGERFAQCCFAETVAYGGGSCMMWAGISFDGKTELVFVPGGGRGGGLTSDRYISDILLEHVVPYAGYIGDDFLLMHDNARYHTSRATTRPHWTGPDLKPIEHVWDELKRRVRSRNPAPSSVNELKLALIEEWEGIPQESVRKLIRSMKNRLRAVIRARGGNTKY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00832962; iTF_00832963; iTF_00832965; iTF_00832971; iTF_00832973; iTF_00832974; iTF_00832975; iTF_01071599; iTF_00832978; iTF_00832952; iTF_00832954; iTF_00832957; iTF_00832958; iTF_00832961; iTF_00832901; iTF_00832966; iTF_00832970; iTF_00832977; iTF_01021188; iTF_01331492; iTF_01331495; iTF_01331496; iTF_01331501; iTF_01331515; iTF_00353036; iTF_00353037; iTF_00353038; iTF_00353042; iTF_01071598; iTF_01063730; iTF_01221527; iTF_01027297; iTF_01221537; iTF_01527169; iTF_01027298; iTF_01221538; iTF_01527170; iTF_01027299; iTF_01221539; iTF_01527171; iTF_01027300; iTF_01221540; iTF_01527172; iTF_01021189; iTF_01027301; iTF_01527173; iTF_01527174; iTF_01527175; iTF_01527176; iTF_01527177; iTF_01527178; iTF_01527179; iTF_00683308; iTF_01332652; iTF_01527180; iTF_00327053; iTF_00831181; iTF_01332653; iTF_01527181; iTF_01527182; iTF_01063727; iTF_01527183; iTF_01527184; iTF_01527185; iTF_00794578; iTF_01527186; iTF_00794579; iTF_01527187; iTF_00794580; iTF_01104308; iTF_01527188; iTF_01063733; iTF_01527189; iTF_00300182; iTF_00382582; iTF_01527158; iTF_01527190; iTF_01527159; iTF_01527191; iTF_01527160; iTF_01527192; iTF_01104313; iTF_01527161; iTF_01527193; iTF_00924634; iTF_01104314; iTF_01527162; iTF_01527194; iTF_01527163; iTF_01527195; iTF_01027292; iTF_01527164; iTF_01527196; iTF_00001149; iTF_01027293; iTF_01527165; iTF_01020254; iTF_01027294; iTF_01104318; iTF_01527166; iTF_01020255; iTF_01221535; iTF_01331487; iTF_01527167; iTF_01027296; iTF_01527168; iTF_00683332; iTF_00683334; iTF_00124240; iTF_01527154; iTF_00445147; iTF_00300184; iTF_01230557; iTF_00300185; iTF_00446107; iTF_00027720; iTF_00027719; iTF_00027721; iTF_00027722; iTF_00027723; iTF_00027724; iTF_00027725; iTF_00036690; iTF_00036670; iTF_01027295; iTF_01027302; iTF_01021184; iTF_01021186; iTF_01063732;
90% Identity
-
80% Identity
-