Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.00027 1.7 9.3 0.3 51 65 16 30 7 35 0.81

2 7 0.081 5e+02 1.4 0.8 6 13 51 58 39 63 0.74

3 7 0.057 3.5e+02 1.9 0.2 55 65 78 88 70 92 0.74

4 7 0.022 1.4e+02 3.2 0.1 5 17 108 120 105 125 0.78

5 7 0.011 66 4.2 0.1 5 14 142 151 138 157 0.68

6 7 1.3e-07 0.00082 19.9 0.4 5 66 171 237 168 241 0.69

7 7 0.026 1.6e+02 3.0 0.2 6 16 257 267 253 281 0.73

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.00027	1.7	9.3	0.3	51	65	16	30	7	35	0.81
2	7	0.081	5e+02	1.4	0.8	6	13	51	58	39	63	0.74
3	7	0.057	3.5e+02	1.9	0.2	55	65	78	88	70	92	0.74
4	7	0.022	1.4e+02	3.2	0.1	5	17	108	120	105	125	0.78
5	7	0.011	66	4.2	0.1	5	14	142	151	138	157	0.68
6	7	1.3e-07	0.00082	19.9	0.4	5	66	171	237	168	241	0.69
7	7	0.026	1.6e+02	3.0	0.2	6	16	257	267	253	281	0.73

Coding Sequence: ATGGCCGGGCTGAGAGAACCGTACAAGATGCCTCCTTCTACTTACTGGGTTGAACGCAAGAAGCACAGCTGTCCTAAGTGTGGCAAGCAGTACAGGTTTAAACACGGCATGCTCTTCCATTTCAAGAACGAGTGTGGCAAAGAGCCTTCGCTGCAATGTCCACACTGTCCTCACAAGACCAAGCAGATGGGCAACTTGAGATCACATATCGCTCTCAAGCACAACAAGATTGCCATCAATTCCTGTCAAAATTGTGGCAAAACGTATCGCTACAAGGGTAACCTACAGTCTCATCTGAAGAATGAATGTGGCAAGGAGCCTTCACTGCAGTGTCCCCACTGTCCTCATAGAACCAAAAGTAATTATGATGATGGATTCTTGGAGGATATAATTACTTCTGCCGAAATTGGTGACAGAAATGGGCAATTCACTTGTCCAAAATGTGGCAAAAAGTATCGTTACAAGTACAACTTGACCTCTCATCTGAAGAACGAGTGTGGAAAGGAGCCTTCACTGCAGTGTCCTCATTGTCCTCACAGGACAAAGGTCAAGAGCAACTTGAAGGCTCACATTGCTACCAGGCACTTCGATATGTTCAAATTGTTCCTTGTTCATCTGTATTTCCTTCCTCAGTTCATTAAAGATGCAATATATTTTCCTGATACAACCAACAATCCGAGTCACATCTGTCCAAAGTGTGGCAAGAAGTATCGTTACAAAAGCGGCATGATCTTTCACTTCAAGAACGAGTGCGGCAAAGCGCCTTCGCTACAGTGTCCGCACTGTCCTCACAGAACTAAGCAGAGAAGCAATTTGAAGTCTCACATGATTTCAAAACACTCTGGACTGTTATAA
Protein Sequence: MAGLREPYKMPPSTYWVERKKHSCPKCGKQYRFKHGMLFHFKNECGKEPSLQCPHCPHKTKQMGNLRSHIALKHNKIAINSCQNCGKTYRYKGNLQSHLKNECGKEPSLQCPHCPHRTKSNYDDGFLEDIITSAEIGDRNGQFTCPKCGKKYRYKYNLTSHLKNECGKEPSLQCPHCPHRTKVKSNLKAHIATRHFDMFKLFLVHLYFLPQFIKDAIYFPDTTNNPSHICPKCGKKYRYKSGMIFHFKNECGKAPSLQCPHCPHRTKQRSNLKSHMISKHSGLL

Sequence clustering based on sequence similarity using MMseqs2