Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.062 3e+02 1.7 0.3 6 20 11 25 7 36 0.70

2 3 4.5e-13 2.2e-09 37.4 3.6 4 69 94 160 92 161 0.86

3 3 1.2 5.8e+03 -2.4 0.0 11 38 206 233 205 237 0.51

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.062	3e+02	1.7	0.3	6	20	11	25	7	36	0.70
2	3	4.5e-13	2.2e-09	37.4	3.6	4	69	94	160	92	161	0.86
3	3	1.2	5.8e+03	-2.4	0.0	11	38	206	233	205	237	0.51

Coding Sequence: ATGTCGGAGAAAAAGAAGAACTGCGCCTTCACGTGGTGTCCGATATGCGAGAATCAGGTCAGTCAAAAGTACAAAGACACCGCGAGGCTGTTGGATCATATACGTACGGTGCATCCACCGGTACCCGACGAACGGCGCGATGACATCAAGCAGAAGGTGCGCTTCCTATTTTTGAGGAAGGGAGTGAAAAAGCTGAAACGCTCGAGAAATGGGTCTAAGCCATCGGTAAAAATAGCTGGAAGAAAAAAGGCTAAAAGTGTCGAGAAGAATTTTCGACGAGAGATGATATTGTGCCCGATTTGCAACGTCGAAGCTGTGCccattatttttgaaaaaactgcAAATCAATTTACGGACTGTCGTCTCGGTGGAATATGTCTCTTGGGATGTTGGCCACTGTGTTTCGTACCGTTAATGATAAACCGCGATAAGAGTATACGTATGGTTTGTCCACTTTGCGGATACGATTACGGCACGTACGACGTGAGAAATTCGAGAGACAGGGAAGCTATCGTCGGGAATGCTCGAGCGTCCATGGGAAAGCCGGaaattcgaatgaaaacatCGAGTACGATTGTACGCCGAGAGAACGACGAGTTAAACGAGGAGGATAATTGCGACCCGAGGGAAGAATCAATAGTAACCGAGGAAGTCGAGCCAAAAACGTTGCCCGTAGAAATGGGAAACTGCAAATTTTGTTTGGTCGCGATGGACGCAAAACGTGAGCACGGTAACTCGCCCTCTAGTTTACCAGGGAACAGGACGAGTCAATCGTTTGTCCATCAGCCGATATCAAGATATTATGACGTTCCGGAATATTGGAGCACACGTTCGAGTTTCACGCACGAAGAACCTCCGCTCGCTTCGACGATGTGTCAACAAGTTCGTTGTCATGTACGAAAATCTTGA
Protein Sequence: MSEKKKNCAFTWCPICENQVSQKYKDTARLLDHIRTVHPPVPDERRDDIKQKVRFLFLRKGVKKLKRSRNGSKPSVKIAGRKKAKSVEKNFRREMILCPICNVEAVPIIFEKTANQFTDCRLGGICLLGCWPLCFVPLMINRDKSIRMVCPLCGYDYGTYDVRNSRDREAIVGNARASMGKPEIRMKTSSTIVRRENDELNEEDNCDPREESIVTEEVEPKTLPVEMGNCKFCLVAMDAKREHGNSPSSLPGNRTSQSFVHQPISRYYDVPEYWSTRSSFTHEEPPLASTMCQQVRCHVRKS

Sequence clustering based on sequence similarity using MMseqs2