Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_964007305.1
Location
OZ023255.1:8534732-8544431[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.8 8.3e+03 -2.9 0.0 46 73 416 443 414 480 0.61
2 2 5.9e-16 2.7e-12 46.7 0.2 6 74 522 591 517 594 0.86

Sequence Information

Coding Sequence
ATGGGAATGGCGCGCAAATGTTGCGTGAAGAATTGCGACAGCGACGGTCAGGAAGCACGTTTCAAGGGACTCCCGTTGCACAAATTTCCAAAAGACGCTCAATTGAGAAGCAAGTGGCTCGTCAGTGGCTCTTTCGAACCAAATTTTAAACCAACGCTCGGCCAATTCGTTTGTCACAGACACTTCAAAAGAGCCGACTACGAACCAATGAAGGGACCCAAATTTGTTCTACGAAAGGGCACTGTACCCACAATTTTCACCGACTATGACAATCATCCGGATCCATTAACGATGCCCGTGAAGACAAGCAGCTCGTATCCTCAGGAAGACCTGGATTTGATCAATTCCGAGATACTAAATATGGATACCTCAGTTCTCGGTGAATTGTCCCTCTTCCCTGAGGCGAGAACTCCCAAGTCAGACAGCTGCGGCGAGGCTTGCAATTCAAGGCCTGGTTCATCGGCGGATTCGCTGAATCCTTCTGAGATGACGGATGCAACTGATGCGGGTTTCAAGTCTGCGGGTGAAAACGACGATATAACCAGAGCCTCTGAACTCTTAGGGGAGAAGATGGATTACAAGCTCGAGGTGAACGGTGATGAGAGTAAGACCTCGAACACGCAGGAAAGCTTTAAGATGAAGAAGGAAGGTACCGAGGGAATCGAGGCAAGCGATGAAAAAGTTAACAATGAAGCGGATAAGCCTAGAACCAAACCAATCACACGTGGATCGTTGAAGTTTTATCCAGGCGCAAGATTGGAAGCCAAAGATTTCAATGACAAATGGTATTCGGCACGAGTGGTCGAAACCGACTGGGCGGAGAGAGAAGTGTTGATACATTTTGACAAGTGGAGCTCGAGATTCGACGAGTGGATACCCATGGATAGTTCGAGACTGAGAGAACTGCAAATGCTACAACCAAGTGAACAAGTTTGGGTGCTTCCAACTGCGGACACGAAGATGAGAGATTTCGTTGTTGGTGAGAGAATTTTGGCTACGTGGGCAGACGGAAGAAAATATCCAGCCAAAGTGAATGCCGTGTTGGGAAACGATAGATACGACGTACTTTTCGACGACGGATACGCAAAAATTGTAAGGTCatcaaaaatgacaaaaatcgCATCGACCACAGAGAAGAAAGCCATGGAAACAGATTCATACATCGGCAGCAAGCAAGAGAGAAGGGATAAGAAACGCAAGCATACAGTGATGGAGCTCTTTCAAACGCATCCTCGAAAGCGCAACAAACCAGAGGTTGAGAAGGTTGTTAAGAAAGAAGAGATATCAACGACCGAAGAGGTGAATAATTATAGCCTGGACAGCAGTACCGATTTCGATAGTTCTGTGCGAGGAACGTATTACGACTCTGGTTCTGAATTGTTGAGAGGTTTTGAGAACGCAAAACCCAAAATGAAGAGTTTTACGAAGAAGATCAAGAGGGATTTGCCTAAGAACGATACAGATCAGGAAGATGATCTCGGGCCCGAGTGGATCGACGGAGAGCCTCAAGGTGTAGAGGCCTTCATCGTGGAAGGAAACGAAGGAACCCGACGATCAATTATAGTCGCGGACAAAAGATTGCCTTCCATGTGGCAAAAACATTTCACCCAACGGAGGGCCGGTACGTCTGCGGGAAAGTGGGATGTTCTTTTCGTCCATAAGCCAAGTGGCAAAAAGTTTCGCTCGCGAAGCGACATTCGAACGTTCGTTGAGAGTCAGGGCTTTGAATTTGATTCGGACATGTTTGATTTCTGCATtcaccgaaaaaaaaacaaaggaccGGTAGCCAAAGTTAAAGTTGAGACACCCACCGAACCGCCAAAGAAGATTAAGACTCTGTTaccaaaaacaaaagcaaCACCAGTTGCACCGATAAGTTCGATGTTGGTTGCATCTACTCCTACTGAAGCTACGACGCCACTCGCTTCAACGACCGCACCCATCGAGGAAGGTGCAGTTTTCATTGGTGGTCTCCGTGTCGAGATGGAGGACAGTGCTTACAAGTGTCCGAAGGACGGATGTAATAAGAATTTTCGCAAAGAGAATCTGCTGCAAATGCACATAAAGCATTATCATCCGGAATACTCGAAATTTTTGGGCTCGACGCCGAACGTTGCCGATTTGGCTTACGCGAGAACTATCGGCGAGTCCGTGATCGACGTGACGCcgaaaaaatcatcgaataatTTCTTGGAGAAGATCAACAAGTTCGAGAAACGAAAAGCTGCCCAGGAGAAGCCAGTTGTACCGGTGACGCAGTTTCTACCATCTCCAGTACCAAGCGTACCTTTGCTCGCGACTTCACCGTTGCCAGCTGTGAATTCCAGTACCGAAACCATTATGCCAGAAAGGCCTTCAGGACCTCCGATTCGCGAGAATGAACCCCGATTAGAGCTTATGTCGCCTGTATCAAACGTCAGCATGGATGTCGACGAGGACTTTGTAAAAAAAGCCGACGCTAGTTGTGCCATGTCACCGGGTGCATTGTTCGATCTCAAAATTCGCGAGGAAAAAACACAAGTGGGTATAAAGACGCTTTTACCTGTGAGACCATCCGTTCCAACGATCGACGCCTCCAGACTCGACAGATCCAAGTCATTGGACGAAGTTGCCAATGCAGACAAGGGAAAGAATCAGAGAAAACGCCAACTTTCTGAGTACAGTTCTGACATTCCCCGACCCAAAGGACGACAagGCATGCAGGAGCTTACGGATGATTATGGGGATTTAGATGACAGTGCATTGGATGCCGAGGGTCCAGCTGCTCTCGTTTATAGATTCAGTCGTAGGAAATCAGACGCAAAGAGCGACGAGAACAGCCAAAGCAGTCAGCTAAACGATTCGCGCCTCGAAAAATCCGATATCCCGAAAGGGGATGCTGCTAAAAGAGATATTAGTAACGAGGCGGAAGAAGGCGATGGTGTTATGATGATGATCAATGGCGAAATGGTGAAGGTCGAGCAGTTGCGCCGAgaggaaattataaattgcacCTGCGGTTTTATGGAGGAGGATGGCTTGATGATTCAATGCGATCTTTGTCTCTGCTGGCAGCATGGTCATTGCAACGccatcgagaaagagaaagacgtgccggaaaaatatatttgttatatttgtCGACATCCTTATCGACAACGTCCATCGTTGAAGCATATGCATGATCAGGAATGGCTCAAAGATGGAAAATTGCCGAGCTTGACCAATCGTACCAAAGACCAATCCGCTATTAATCGACGAACCTCGATGTTGAAACGATCGTATGATCTTGTCGCGGCACTGCTACAGATTCAGCAAATACTTCACAGTCTTCGAGTCAAGATCAGCGTGGCACAAAAAAAGGATCACCCTAAATTGTATCTTTGGGCGAAGAATTGGGAAAAATCTGAGATTCCTGAACCAACGATCGAGCCTGTGGCTGTGATGCAAACGGTGAAGCCCAAGGTCGAAATTGTTGAGCCTGGAATGGATACTTTTGTCGAGCCGAAAGTGGAAGTTCCGACTGTAGTGAAGAAAGACCCTGATGAAAAATCAATCGCTTCTGATACggaattgatgaaaattcTTGAAGAGGATAGCACACACTCGGATGAAACAAAAGTTGGATGCAAAAAAGAGGATACGAAAGATTCTGGTGGCGAActtgatattttattgaacACACTTGCCGAGAACGAGAATTCTACTGATGTTCAAGATAATTCGTCTGCCATGgataatacgaaaaataatactGAATTACAAAACGATGTATCAACGATCAATACATCATCCGTAAATCTGGATAATCCTGAAAAAATAACACCGGCTGAAGCCATATCGTCTATTCAAACACAAGAACCCCCTGTACCTGTGCAACCTTTCATACCGGAGCCCGAAGCTCCGATTGATCCCGCCGAGTGTCGACACCGACTCTTGGAGCATATCGAACATTTTCAGAATCACATAGATTCGCGATTGACTACAATCGAGGCACATGTTTGTGCATTGGAAACTATGGATCTTGACTCGAACGCAACGTCTACGGATGTGCAGCGTCGAACGAAGCAAACGATTCAGATGTTACTTCGAGATTTGGGGACCGTTCGAAAACTGGCCGCTCTGTGCTGA
Protein Sequence
MGMARKCCVKNCDSDGQEARFKGLPLHKFPKDAQLRSKWLVSGSFEPNFKPTLGQFVCHRHFKRADYEPMKGPKFVLRKGTVPTIFTDYDNHPDPLTMPVKTSSSYPQEDLDLINSEILNMDTSVLGELSLFPEARTPKSDSCGEACNSRPGSSADSLNPSEMTDATDAGFKSAGENDDITRASELLGEKMDYKLEVNGDESKTSNTQESFKMKKEGTEGIEASDEKVNNEADKPRTKPITRGSLKFYPGARLEAKDFNDKWYSARVVETDWAEREVLIHFDKWSSRFDEWIPMDSSRLRELQMLQPSEQVWVLPTADTKMRDFVVGERILATWADGRKYPAKVNAVLGNDRYDVLFDDGYAKIVRSSKMTKIASTTEKKAMETDSYIGSKQERRDKKRKHTVMELFQTHPRKRNKPEVEKVVKKEEISTTEEVNNYSLDSSTDFDSSVRGTYYDSGSELLRGFENAKPKMKSFTKKIKRDLPKNDTDQEDDLGPEWIDGEPQGVEAFIVEGNEGTRRSIIVADKRLPSMWQKHFTQRRAGTSAGKWDVLFVHKPSGKKFRSRSDIRTFVESQGFEFDSDMFDFCIHRKKNKGPVAKVKVETPTEPPKKIKTLLPKTKATPVAPISSMLVASTPTEATTPLASTTAPIEEGAVFIGGLRVEMEDSAYKCPKDGCNKNFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESVIDVTPKKSSNNFLEKINKFEKRKAAQEKPVVPVTQFLPSPVPSVPLLATSPLPAVNSSTETIMPERPSGPPIRENEPRLELMSPVSNVSMDVDEDFVKKADASCAMSPGALFDLKIREEKTQVGIKTLLPVRPSVPTIDASRLDRSKSLDEVANADKGKNQRKRQLSEYSSDIPRPKGRQGMQELTDDYGDLDDSALDAEGPAALVYRFSRRKSDAKSDENSQSSQLNDSRLEKSDIPKGDAAKRDISNEAEEGDGVMMMINGEMVKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEKEKDVPEKYICYICRHPYRQRPSLKHMHDQEWLKDGKLPSLTNRTKDQSAINRRTSMLKRSYDLVAALLQIQQILHSLRVKISVAQKKDHPKLYLWAKNWEKSEIPEPTIEPVAVMQTVKPKVEIVEPGMDTFVEPKVEVPTVVKKDPDEKSIASDTELMKILEEDSTHSDETKVGCKKEDTKDSGGELDILLNTLAENENSTDVQDNSSAMDNTKNNTELQNDVSTINTSSVNLDNPEKITPAEAISSIQTQEPPVPVQPFIPEPEAPIDPAECRHRLLEHIEHFQNHIDSRLTTIEAHVCALETMDLDSNATSTDVQRRTKQTIQMLLRDLGTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2