Basic Information

Gene Symbol
Aef1
Assembly
GCA_963457695.1
Location
OY735248.1:11324052-11325001[+]

Transcription Factor Domain

TF Family
zf-GAGA
Domain
zf-GAGA domain
PFAM
PF09237
TF Group
Zinc-Coordinating Group
Description
Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.0049 61 4.3 0.2 22 48 168 194 165 198 0.86
2 4 3.1e-06 0.038 14.6 0.0 21 52 195 226 192 228 0.90
3 4 0.0031 38 5.0 0.0 21 51 223 253 220 254 0.87
4 4 8.7e-05 1.1 9.9 0.1 21 47 251 277 249 284 0.88

Sequence Information

Coding Sequence
ATGCACATTAAGAATCTGCAACATGCTCATGCTGCGGCGGCAGCAATGGGCAATTGCGAAATTGTAATTGTGGCATCGTCGCCCAACAACgccaacggcaacaacaacaacgagagcTCAAATGGCAcgcatcagcaacaacaacaacagcatcagcagcagcagcagcaacaacagccaacgcaacagcagcaaccacaGCCGCCGCCTACAACTGAAATACAACTACCCTTTAATATGCATCTGTCGGCCGCCACCGCGGAAGCGCATGCAGCAGCACAAGCAGCCGCGATGGCAACAGCACAAGCTGCGGCTGCACAAGCAGCAGCCGCCGACCAGGGAGGTGGCCATCATACCACCATTTTGCAACAGCATCCACTGGCGCATCTCGTGGCCACGGCAGCACAGAGTCCCACTGTGTCGGAGCAGCATTTCAATACGCGTAGCGGCAGCGGTGGCGAAGTGGTGGCCAATGGACATAATGGCAATGTCGGTGGGCCCGAAAAACCCTTCCAATGCAACGTCTGTGAACGACGGTTCCGACAACTCAGCACCCTCACGAACCATGTGAAGATTCACACCGGTGAAAAACCGTACAAATGCAACATTTGTGATAAGACCTTCCGTCAATCGTCCACGCTCACGAATCATTTGAAGATCCATACCGGCGAGAAGCCCTTCGTTTGCTCCTACTGTCCCAAGAATTTCCGTCAACTGAGCACGCTGACTAATCATTTGAAAATCCATACAGGTGAGAAGCCTTTCGAATGCGCTGTCTGCAAAAAACAATTCCGCCAATCGAGCACACTCAATAACCACATAAAGATCCACGTCATGGATAAGGTATACGTACCCGTGAAGATCAAGACCGAGGAGGAGGAGGGATGA
Protein Sequence
MHIKNLQHAHAAAAAMGNCEIVIVASSPNNANGNNNNESSNGTHQQQQQQHQQQQQQQQPTQQQQPQPPPTTEIQLPFNMHLSAATAEAHAAAQAAAMATAQAAAAQAAAADQGGGHHTTILQQHPLAHLVATAAQSPTVSEQHFNTRSGSGGEVVANGHNGNVGGPEKPFQCNVCERRFRQLSTLTNHVKIHTGEKPYKCNICDKTFRQSSTLTNHLKIHTGEKPFVCSYCPKNFRQLSTLTNHLKIHTGEKPFECAVCKKQFRQSSTLNNHIKIHVMDKVYVPVKIKTEEEEG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01133176;
90% Identity
iTF_01055458;
80% Identity
iTF_01055458;