Basic Information

Gene Symbol
-
Assembly
GCA_963691935.1
Location
OY829914.1:20093972-20095679[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.00023 0.045 16.0 2.1 3 23 231 251 229 251 0.96
2 11 2.3e-05 0.0045 19.2 4.2 1 23 257 279 257 279 0.98
3 11 4.3e-05 0.0085 18.3 0.3 3 23 287 307 285 307 0.98
4 11 2.7e-06 0.00052 22.1 0.8 1 23 313 337 313 337 0.96
5 11 6.4e-05 0.013 17.8 1.0 2 23 344 365 344 365 0.97
6 11 2e-08 4e-06 28.8 0.7 1 23 371 393 371 393 0.99
7 11 0.0047 0.93 11.9 0.4 5 23 405 423 399 423 0.88
8 11 1.1e-05 0.0022 20.1 3.8 3 23 434 454 432 454 0.96
9 11 3.7e-05 0.0072 18.5 0.9 1 23 460 482 460 482 0.98
10 11 6.1e-07 0.00012 24.1 0.5 1 23 488 510 488 510 0.99
11 11 5.3e-05 0.01 18.0 0.9 1 23 516 538 516 538 0.97

Sequence Information

Coding Sequence
ATGATCGATTGTTCGGAATATATCGAtgaaacggataaaattgacTTCGGCAAAATATGTCGTTGTTGTTTGGTTCAAAGTTCCATTATGAAGTCCATATACGATGAAGATTTACCTGCTATGCTAATGGCATGTACCACAATCAATATCACAATGGATGATGGCCTACCCTCGTTGATATGTTCCAGTTGTGATACGCAAATTAAACAGTCTTATTTATTCCGGCAGTTGTGCGAACGGTCGGATGGAACACTACGCCAGTACTTTGAGTCGCAGCAGATAGCATGCCCGTCCGATTTAAATATAACACTTAACACGGACATTTTGAATGAATCGGATGATAATTTAAACCAGTACCAATTGGTCTTAGTCGAGTACGCAACCGGAGAAAATTCGACTGTAGCTATACCGTCTAAAAACGATCTCAATTTAATCTCAGGTCAGACTGAAAACTGTACCGATGAAAATCTGGAAGAGGAGATAACATTAAAAAGTTCGCTAGATTTAGCCGACGAGGATCACGAAGCCGTTCAATTTTTGAACGaggaatttattgaaattttgcagattcaaacaaataaacaagATGCTCAGGAATATGTCAATATATGTAACGATGTTTTGCCTGCAGCCTCCGAAGATCTCATAGTGGAGGATCCAGCTCCAACGCCAACCGAGGACGATATTATTTGcgacatttgtaataaaatatttggcgaTAAGCATAAGCTAAGCAGGCATAAAAAACAGCACATGGCGGAACGTCCTTTCGAATGTAACTTTTGTGACAAAAGCTTTGTGGAGAGGGGCTGTttgaaaaaacatttgaagCGGCATCGGGGTGATAAACCGTTCGGTTGTGGAGTCTGTGGCATGAAGTTCTATGACAAATCGAGTCTTGTAAGTCACACTAGGATTCACACAGGTGACAAGCCGTTCGTTTGTCAGTTTGAAAATTGCGGAAAAGCGTTTACCCAGTCCTCCCAACTCGAGacccataaaaaaattcatagtACTGAAAAGGCGAATGTCTGCGACATTTGTAACAAACGTTTCACGCTTTATAATCAACTGAAAATCCATAAACGGATCCATACCAATGAGAAACCGTATGAATGTGGTTTCTGTGGCAAAAATTTTTCCCAATCAGGTAACTTAACCACGCACATACGTACCCATACCGGAGATAGGCCTTTCTTGTGCTCATTTAACGCATGTGAGCGTAGTTTCGCCTCCGTTGGTGAGCTAAACTCTCATTTGCGTAAGCATACGGgtcagaaaattgaaaagaaattgGCGTGCCATGAATGTGGTAAAATGTGCCGAACCCGTTACGAACTACAAAATCATTTGAACTCGCATGCCGGTGTTAAACCGTACATATGCAATGTATGTGAtaaaagttttttgatgagttcGCATTTGGTTGTGCATATACGAAATCATACGGGCGAGCGACCATACCAATGTGATTTTTGCCCCAAGGCGTTTACAACGCAGCAAATGGTGAAGGCTCATATGCGGATACATACGGGCGAAAAGAAATTCGCTTGCGATATTTGTGAAAGGAGGTTTACGCAGGCATCAGCCCGAAATACGCATCGCAAGACACATTCTCGTGTGTGGCCCAAGCAAAAAAATGTAGAAGCGTGA
Protein Sequence
MIDCSEYIDETDKIDFGKICRCCLVQSSIMKSIYDEDLPAMLMACTTINITMDDGLPSLICSSCDTQIKQSYLFRQLCERSDGTLRQYFESQQIACPSDLNITLNTDILNESDDNLNQYQLVLVEYATGENSTVAIPSKNDLNLISGQTENCTDENLEEEITLKSSLDLADEDHEAVQFLNEEFIEILQIQTNKQDAQEYVNICNDVLPAASEDLIVEDPAPTPTEDDIICDICNKIFGDKHKLSRHKKQHMAERPFECNFCDKSFVERGCLKKHLKRHRGDKPFGCGVCGMKFYDKSSLVSHTRIHTGDKPFVCQFENCGKAFTQSSQLETHKKIHSTEKANVCDICNKRFTLYNQLKIHKRIHTNEKPYECGFCGKNFSQSGNLTTHIRTHTGDRPFLCSFNACERSFASVGELNSHLRKHTGQKIEKKLACHECGKMCRTRYELQNHLNSHAGVKPYICNVCDKSFLMSSHLVVHIRNHTGERPYQCDFCPKAFTTQQMVKAHMRIHTGEKKFACDICERRFTQASARNTHRKTHSRVWPKQKNVEA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01053669; iTF_01052501;
90% Identity
iTF_01053669; iTF_01052501;
80% Identity
-