Basic Information

Gene Symbol
-
Assembly
GCA_932525705.1
Location
CAKOBH010000189.1:398089-400596[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.00014 0.026 16.7 1.0 3 23 233 253 232 253 0.97
2 14 0.00017 0.031 16.4 2.0 1 23 258 281 258 281 0.97
3 14 0.18 33 6.9 1.2 3 23 356 377 354 377 0.90
4 14 2.6 4.8e+02 3.3 1.5 3 23 382 403 381 403 0.94
5 14 0.34 62 6.1 5.6 3 23 421 441 416 441 0.92
6 14 1.1 1.9e+02 4.5 0.3 1 20 459 478 459 482 0.85
7 14 0.16 30 7.1 0.0 1 23 523 545 523 545 0.97
8 14 5.8 1.1e+03 2.2 2.6 2 23 550 574 549 574 0.91
9 14 0.00093 0.17 14.1 0.8 2 22 581 601 580 601 0.94
10 14 8.7e-05 0.016 17.4 1.3 1 22 608 629 608 629 0.96
11 14 1.9e-06 0.00035 22.6 1.8 3 23 638 658 637 658 0.99
12 14 6.6e-06 0.0012 20.9 0.2 1 23 664 686 664 686 0.97
13 14 0.00041 0.075 15.2 3.3 1 23 692 714 692 714 0.96
14 14 0.035 6.4 9.2 5.7 1 23 720 743 720 743 0.97

Sequence Information

Coding Sequence
ATGGAACTATCATCTGACTTAGAATTAGACATACCAAATATGTGCCGAGTGTGCTTATTGCAAAAAGAAAAACTGAATAATATCTTTTCAAATTGCATTGTGGAAGGATACGTAATTTCATTGCCTGAAATTATAAAATCCTGCTTAGATTTATATTTACAAAAAGATGATAAAAATTTGCCAAAAAAGATTTGCGATCTTTGCAAAATTCAGGTAATCAATTTTTATTCATTTAAAGAAAAATCCAAGAAGGTCGAGGAAGCGCTAAAAAATCTGCTGAGCTCAACTCGTTTGAAAAGTGAAGGATCACCACAGGTAGAGATAATTCCAAATAGTGCAAGATCAATTAAAATTGAAAATTCGACTGATGTGGTTGAGTACGACGAACAAGAGCTACTTCAGGAAAATTCGACAATGATGACTGAACCCTTATCAACCGTTGAAGCATTATATCCGCAAGAACAATTTCAATATTCAAATAGCGATCAAACCGAATGTAATGTAATTCCTGGAAGTGAAATGTGTAGCGCTAAAATTGAGTCAATTGAATCACATGACGAAACATTAGACTGTGAGGAATTGGTAGAAGAGCGAGAAGAAATTGAGGAAACGGAAGAAGATCTAAGGGAAAATGTTGAACTGCAACATGATGCAATTATTGAACCTTCCGAGGTTGTTGATAATTTATCAAATGCTTGTAATATGTGTGACAAAAAATATGAAACCGTAAATAATTTAAAGCGGCACTTGGACAAACATAATGGAATTTTTTTTAAATGCCGATTGTGTCCAAAAATGTACGCACACCAAGCCTCACGTAATCGCCATATGAGACTTGGGCATCCAAAACAGGTAAAGGTTATCATGTTACAAACAGAAAACCCTTTCCAAAGGAATGATCCGGTGAATCCACCAATTAAAATAAATGCTGGTGAAAATTTACAGTCAAAGAGAATCACAAGGTTATCAAAAATTTTGGACGAGAAAAATTCAGATACTTGTGATTTGCAACCTGTCCTAGATGAAGAGGAAAATGTGGCAATGGTGGATGATCTTGAATGCTTGTGTACAATTTGCGACGCAAGTTTTGAAACTGAACGCTTGTTTGTGGAACATTCAAAATTTGAACATCCTGATGTATTTTGTAGTAATTGTAGTAAATTATTTCTTAGCTCAGAGGAGCGAAATAAGCATATGTCTCAAGAACATTTTTATGAATCGAGCAACAGTAAATTAAGTAATATTACTTGCCACAATTTTTGTCGCTTTTGTCAAAAAAAATTTAAATCAGTTATTGAGTTAAATACTCATAGAGAGTTGCATGAAACTTTGAATAAATGGATGCAAAATGCCGTATCGCCAATGGTAACCTTTTACGCCTGTTACAAATGTAATACGGTTTTCTTAAGTGAACAAAGCCTTCAAGGGCATACCGTTGCGAAGCATAGTGAACCACCAAAAAAATTTAGTTTAGATGATGACAGTATTGAATGTACCGATTATCAATTCCTCGATGACGACGAAGCTACAATGGTCACCCAACGTAGTTTACAAAGAGAAGAACCGTTCATTTGTGGAGTGTGCAATGTCGAATTGCCTAACGAAAATGAAATGCGAAATCATATAATTATTCACTCAACCAAATTGTCTTGCCCATTTGATGAATGTGGATGCGAGTATAATAGTTTCTCTAGATTTAGTTTACACTTAATTCACAGGCATTTAAATCGAAACGAATTGAAATGCATGCATTGTGGAGAATCATACCAGAGCTACGATGATTTGCAGAATCATTTAAAAAAAACGTGCCCCGAGCGAAAGTATAATTGTAATCATTGCGATAAAAGTTTTTTTTCGGTTAAAGCGTTGAGCATTCATATGAAAACTTCGATTGAGAAAAAAACGATTCTTTGTCAAATCTGCGGCAAATCTTTTACACATTCAGGCGAATTAAAAATCCATTCAAGAACCCATACAGGAGAGCGTCCTTATAAATGTAATATATGCGGCAAAGCATATAAAACTGCCAGTATGCGAACAGCCCACATGGATGCACATATTCAAGGAAAAACATTCCTCTGTACAATTTGCGATAAAAAGTTACAAACACGAACCAGTTTTCGTACTCATATGCGACGGCACACCGAAGATAAAAAGCATCAGTGTGAAATTTGCTTGAAGAAATTTTTTACCAAATATCACGCTAAACTTCATACGATGAAAATTCATGATAATCCTAACCGAATTCAAAACAAAAATGCTGCGGCCTCCACGCAAGTTTAG
Protein Sequence
MELSSDLELDIPNMCRVCLLQKEKLNNIFSNCIVEGYVISLPEIIKSCLDLYLQKDDKNLPKKICDLCKIQVINFYSFKEKSKKVEEALKNLLSSTRLKSEGSPQVEIIPNSARSIKIENSTDVVEYDEQELLQENSTMMTEPLSTVEALYPQEQFQYSNSDQTECNVIPGSEMCSAKIESIESHDETLDCEELVEEREEIEETEEDLRENVELQHDAIIEPSEVVDNLSNACNMCDKKYETVNNLKRHLDKHNGIFFKCRLCPKMYAHQASRNRHMRLGHPKQVKVIMLQTENPFQRNDPVNPPIKINAGENLQSKRITRLSKILDEKNSDTCDLQPVLDEEENVAMVDDLECLCTICDASFETERLFVEHSKFEHPDVFCSNCSKLFLSSEERNKHMSQEHFYESSNSKLSNITCHNFCRFCQKKFKSVIELNTHRELHETLNKWMQNAVSPMVTFYACYKCNTVFLSEQSLQGHTVAKHSEPPKKFSLDDDSIECTDYQFLDDDEATMVTQRSLQREEPFICGVCNVELPNENEMRNHIIIHSTKLSCPFDECGCEYNSFSRFSLHLIHRHLNRNELKCMHCGESYQSYDDLQNHLKKTCPERKYNCNHCDKSFFSVKALSIHMKTSIEKKTILCQICGKSFTHSGELKIHSRTHTGERPYKCNICGKAYKTASMRTAHMDAHIQGKTFLCTICDKKLQTRTSFRTHMRRHTEDKKHQCEICLKKFFTKYHAKLHTMKIHDNPNRIQNKNAAASTQV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01052646; iTF_01054713;
90% Identity
iTF_01052646; iTF_01054713;
80% Identity
-