Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.00017 4.7 9.5 0.1 21 44 119 142 111 150 0.87

2 7 0.0092 2.5e+02 4.0 0.4 23 45 149 171 145 178 0.85

3 7 0.0053 1.4e+02 4.8 0.3 24 43 178 197 174 205 0.87

4 7 0.002 53 6.1 1.3 23 47 205 229 195 234 0.82

5 7 0.0093 2.5e+02 4.0 0.5 23 44 233 254 229 258 0.86

6 7 0.0022 61 6.0 0.0 21 43 259 281 254 289 0.88

7 7 7.7e-06 0.21 13.9 0.2 23 44 289 310 286 314 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.00017	4.7	9.5	0.1	21	44	119	142	111	150	0.87
2	7	0.0092	2.5e+02	4.0	0.4	23	45	149	171	145	178	0.85
3	7	0.0053	1.4e+02	4.8	0.3	24	43	178	197	174	205	0.87
4	7	0.002	53	6.1	1.3	23	47	205	229	195	234	0.82
5	7	0.0093	2.5e+02	4.0	0.5	23	44	233	254	229	258	0.86
6	7	0.0022	61	6.0	0.0	21	43	259	281	254	289	0.88
7	7	7.7e-06	0.21	13.9	0.2	23	44	289	310	286	314	0.91

Coding Sequence: ATGTTTTTTCCTATGTTTGATGGACATGAAATTCAAGTAGCTCATACAGAAATTCAGCCTAGTAATATAGCGACCGAAGTTAAAGACCCGGTTATTAGTAACCTGCATAATAATACTCATCACATCACTAGCAATAATAATAGTAATAGTAATAATCATGTTAGGACAGAAACAAATTATTTGGAACACTACAAGAAGATAAAATGTACTCAATGTCGGAAGCGTTTCGATACCGAGGCCCAAATGCTGGCGCATCGTGAACGTCATATAATCGAATCTACATTTTCCTGTGGTGTGTGCCCCAAGAAATTCACAAGTCACAGCAGCTTGTGGAAACATATAAAATCGCATACGGGAGAACGGCCCTTTATATGTGAAATATGCCATAAGGGGTTCACGCAATTGGCCAATTTACAGCGGCATCATTTTGTTCATAATGGTTTGCGACCGTACGAATGTCCAGTGTGCCAGAAACGATTCTCTCAACATGCCAATATGATCAAGCATCAATTACTTCATACAGGTCTAAGACCATTTGAATGTCCCATTTGTCAAAAACGATTCACACAACATGCCAATATGATAAAACATCAAAGATCACATACAGGACTCAGACCATACGAATGTCCAATATGTCAGAAACGCTTTACACAGCATGCCAACATGATTAAACATCAGAGATTACATACAGGTCAAAGGCCCTATGAATGTCCTGTGTGTCAAAAACGTTTTACTCAACATGCGAATATGATAAAACATCAGCGAGTGCACACAGGCGAAAAGCCATTTAAATGCAAAGTCTGTGATAAATCATTTGCTCAGAGAGCAAATTTAAAGAAACATGAAATGGTTCATACAGGTGTGCGACCTCATAGCTGTTCAATATGTTTTAGAACATATGCACAATCGGCCAATTTAAAAAAACATTTACTCGTTCACGAAAAGGAGCAGAAACAAGCGCGAGATTTTGTATTGTGA
Protein Sequence: MFFPMFDGHEIQVAHTEIQPSNIATEVKDPVISNLHNNTHHITSNNNSNSNNHVRTETNYLEHYKKIKCTQCRKRFDTEAQMLAHRERHIIESTFSCGVCPKKFTSHSSLWKHIKSHTGERPFICEICHKGFTQLANLQRHHFVHNGLRPYECPVCQKRFSQHANMIKHQLLHTGLRPFECPICQKRFTQHANMIKHQRSHTGLRPYECPICQKRFTQHANMIKHQRLHTGQRPYECPVCQKRFTQHANMIKHQRVHTGEKPFKCKVCDKSFAQRANLKKHEMVHTGVRPHSCSICFRTYAQSANLKKHLLVHEKEQKQARDFVL

Sequence clustering based on sequence similarity using MMseqs2