Basic Information

Insect: Neoneuromus ignobilis
Gene Symbol: MBD-R2
Assembly: GCA_029203775.1
Location: CP092095.1:13149131-13155099[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.6e-15 8.5e-12 45.3 0.1 6 70 428 490 423 497 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.6e-15	8.5e-12	45.3	0.1	6	70	428	490	423	497	0.92

Sequence Information

Coding Sequence: aTGGGACGTAAATGTAGAGTGAAAGATTGTTTATCAGATTCTAAACGATCAGAGGATGTGGGTGttacttttcataaaatacCAAATCATAGTGATATACGGCCCAAATGGCTCACTTTATGCAAAATTCctctagaaaataattcaaataaaattatttatgtatgttcaCGTCATTTTCGCAAACATGATTTTTGCCAATTTAAAGgtacaaaatatatgttaaaacaaGGTGTTTTACCATCTATATTTCCTTGGACTGATTTAAACGAAATCAAGTCAAAAATTTTATCAGAAGCGGCAAAATCAGATACGgctatttgtaataaaatggaAGATTTAGAGGTtactaatcaaataaatttaaaatctgatACGAACACTTCTTCCACAAAGTCTGAAACATTTGTTCATACATCTCAAAAAAATACTGAAGGAAAATTAGATATAGATAGAGAAAAATCTGAATTGCAATCAGATATAAAAACTGAACCTGAAAAATCAGACACAAAATTAACAGACACTAACATGTCAAGCAATTTCAAATGTTTTAAAGAAGAATTCTCGCAAGGAATGCGAGTGGAGGCAACAGATTTTAATGGTATTTGGTTCCCTGCAAAAGTTCTAGAAGTAGATCAAAGTGAAAATGAAGTATTCATTCAGTTTGAAAAATCTGCTAATCGATCTAATGAATGGATTCCAATGGATAGTAAAAGATTAAGACCATTgcaattttctaacaaaaaacaAACTTTTGAAGTAGGTGAAAGAGTTATGGCTATGTGGactaattcaatgaaatttcgAGCAACGATACAAAAAGTTTTAGATTGTGGagATTCATATGAAGTTCTTTTTGATGATggtataaaaagtgttttaaaatcTTCCAAAATATCTAAACCAACATCGACTATAGAGTCTGCTGTTCCGAGACCTCATCCATCACCTTTGTTTGCTCCTGTAGAGAGCACAAAACAAGAACGTCGTGATCGTAAGCGGAAAATAATAGTGTCTgagttatttcataaaaaacgtGTTAAACAAGATTCCCTTGTTCAATCTGTTCCTATTCCTGAAAAAAGTACATCCAGTTTGGTTGATAAAACACCAATTGACAAACCAAGAAGATCATCTGATGCAAAAGCTACACTGACTAATGttttagcAAGTAATGCACAATCAGAAAATGTGTTAAATAATGATGAATGGATTTGTCAATGGATTAATGGTCAACCTGTTGGAACTCCAGGAGTTATAGATTCTAGAAAATCTGTTATTGTCACTGATCATCGTTTACCACCAAGTTGGACAAAACATCTTGTTTGTCGTTCACAAGGGTTTTCAGCAGGAAAATGGGATACAATTTTGGTCAAtgctGATGGTAGAAAATTTCGATCAAAAAAtgaagttaaattatatttagaacaaGAAAAATCGAGCTATAGTTTAGATCAGTTTGACTTTGGTTTACATTTGAAAAGAGCTCGATCACTTGGCCTGTTTAAAGTCACAGAAAAATCAACATCACCAACACCAAAAGATGGAAATTCTTCAGTAATAAAGCAAACAACAGTAACAAAATCACAGTCCCCAAAACACGATcttaaagatattaaatcaCCAGAAAGATTAGAAGATAATGAAACATTTACAGATGATGAcaCATGTGAAAATactcttaaaataatatgtgaagATGGAGGTTATAAGTGTCCTATAGAAGGATGTGGTAAAAATTTTCGACGAGAAAATCTTGCTCAAATGCATATTAAACATTATCATCCagaattttccaaatttattgGCTCTACGCCAAATGTAGCAGATCTTGCTTATGCAAGAACTGTAGGAGAACCAATAGAAGATTTTGTTTTAAAAGGACGTGTAAATCAaggaataattgataaaaaatctgAGCCTATTCAAAAGACCCCAACACGAATTGaaccaaaatttcaaattaaatcattaaatattccaCCTCAAGTAACAACACCAACAGAAAAAAAGTCACCTATTCAAACACCTAAGGTttcagaaaaaattaatgaaggaAATAATGATAAATCTCAACCTACAACTCCAAAAGTACATAAACAAGaatctgaaataataaaattgttgaatagTGAAACAAAAATTCCAAAAACACAAGATGCTTATAAAATAGAatcaaaattgtcaaaaaatgaTGCAGCATTATCACCTATTGCAGAGCAAACAACAAATTTAAGTAAAAGTCCATTAATAGTTACACCTTTAGATCCAATTAAAACTGAAACTATAAAAACAACAGATGTGCAAAATAAAGATTCAGCAAAATCTCcagattcaatttttaaaagagaTGAATCAAGACCATCTGGtggaataaaaacattattacctGTTATTAGAGTAACTACTGAAAATCAACGTAAGCCAAATGAAGATCAACCACAATCCTCTGAGGTAGATAATCACAATAAACTTCAAATATCAACAACTTCAACACCAGAAAAAAACATAAGAACTAATCGTAAAAGATACATTTCTGAAGCAGATCTTCATAAAAAGCgtaaatatacaaaacatgATTATTCATATCTATCAGATCCTCGAGATTCAGACAGTAGATCTCCAGATTATACCactcaaacaaaaaataaaaagaaatctgtTGATTTTGCTGATGTTCCTGCATCATCAAGTACAGTTACACAAGACTTAAATCAGCACATTATAACTGAAAATGgagaagtaattaaaattgaacaaatgAAACAAGAAGAAATAGTAAACTGCACATGTGGATTTATGGAAGAAGATGGTCTTATGATTCAGTGTGAATTATGTTTATGTTGGCAACATGCTTACTGCAACAATATTGAAAGAGAAGATCAAGTACCTGAAAAGTATATTTGTTACATATGTATGAATCCATTAAGAATGCGATCCTCACAAAAATATGTTCATGATCAAGATTGGTTAAAGAAAGGAGTACTTCCCACAGCAAATTATCATTCAGTTGACAAAGAAGTTCTTAATGAGCGCTTTGAAAAACTAAGAAGATCTCATGAATTAAGTGGTAATTTGAATGAACTTAGGTCAGTTCTTCACAGTTTAaaggttaaaattaaaattgcccAAAATAAGGATCatccaaaattttatttatggtcaAAACCTtgggaaaaaattaatatgtcacATAATGTTAAAGATTTATTAGATAACCAACAAAATAAATCAGATATCAAAGATAAGTCATTATGTTCAAATCAAACATATGTTAATTATACTGAAGATGAAATGTCTACTCATAATGATATTGAACTTTCATTGAAAAAGTTACTGAATTGTTCAACAGATTCATTAAAAAGAGAAacggataataaaatatttgatgacAGTTTGTCAGAAGTTGCAGATATTAAAGATGTGAATTCTTCACAACAAACTGCACAAGaccttttaaaaattttagaaggTACTGACATCTTAAAGCATTCAGAAACTGAAACTTTAGTTACTGAAAGTCAGGAAAGTGATATGtccaaagaaaaattattgaatactgaATATTccaaattagatttaaattccTTATTAGTGAATACTAATATAGATTCAGTTAATGttgatattgatttaaaaactgaAAGAGGAACATCAGTAAATGATTTGACAGCAACAATAAATCCAAATGAATTGGAAGCAGTATTGCGGTCAGATTTATCTGAAGATAAAGTATTGACACCTTTAGATGAACATTCAAAGTCAGCTTTTTATGATACAATAAAATCAGAAAACAAATCTATTTCTTTTACTACAGATGCAACTGATGTTTCTATGCATTCAGGTGTTATTAGTTCTGGAGAAGTATCAGATGGTGAACTTATGAGCCAAGCACTTGCTGGTGAACTTTTAAGCTCGCCAACTACAgcactaaatttaaattttactcagAGTGATATTGATACTATTGAAAAAAGTATCCGaataCCAGAAGCACCAGTACCAGAAGCTAAAATTGAACCTGAGGTTTGTCGCCAAAATTTAATAGACAATATTCGACATTATCAACAGTTAGTCAAGGAAAGAATGAATGCAGTTGAAGAAGAAATTGCAGTTCTTGAGGCACAAGATCCAACACCAGAAAATGAAggaaatattaatgaaacagTAACAATGATGTTACGAGATCTTAGTCAGATGCAAAAATTGGCagcattatattaa
Protein Sequence: MGRKCRVKDCLSDSKRSEDVGVTFHKIPNHSDIRPKWLTLCKIPLENNSNKIIYVCSRHFRKHDFCQFKGTKYMLKQGVLPSIFPWTDLNEIKSKILSEAAKSDTAICNKMEDLEVTNQINLKSDTNTSSTKSETFVHTSQKNTEGKLDIDREKSELQSDIKTEPEKSDTKLTDTNMSSNFKCFKEEFSQGMRVEATDFNGIWFPAKVLEVDQSENEVFIQFEKSANRSNEWIPMDSKRLRPLQFSNKKQTFEVGERVMAMWTNSMKFRATIQKVLDCGDSYEVLFDDGIKSVLKSSKISKPTSTIESAVPRPHPSPLFAPVESTKQERRDRKRKIIVSELFHKKRVKQDSLVQSVPIPEKSTSSLVDKTPIDKPRRSSDAKATLTNVLASNAQSENVLNNDEWICQWINGQPVGTPGVIDSRKSVIVTDHRLPPSWTKHLVCRSQGFSAGKWDTILVNADGRKFRSKNEVKLYLEQEKSSYSLDQFDFGLHLKRARSLGLFKVTEKSTSPTPKDGNSSVIKQTTVTKSQSPKHDLKDIKSPERLEDNETFTDDDTCENTLKIICEDGGYKCPIEGCGKNFRRENLAQMHIKHYHPEFSKFIGSTPNVADLAYARTVGEPIEDFVLKGRVNQGIIDKKSEPIQKTPTRIEPKFQIKSLNIPPQVTTPTEKKSPIQTPKVSEKINEGNNDKSQPTTPKVHKQESEIIKLLNSETKIPKTQDAYKIESKLSKNDAALSPIAEQTTNLSKSPLIVTPLDPIKTETIKTTDVQNKDSAKSPDSIFKRDESRPSGGIKTLLPVIRVTTENQRKPNEDQPQSSEVDNHNKLQISTTSTPEKNIRTNRKRYISEADLHKKRKYTKHDYSYLSDPRDSDSRSPDYTTQTKNKKKSVDFADVPASSSTVTQDLNQHIITENGEVIKIEQMKQEEIVNCTCGFMEEDGLMIQCELCLCWQHAYCNNIEREDQVPEKYICYICMNPLRMRSSQKYVHDQDWLKKGVLPTANYHSVDKEVLNERFEKLRRSHELSGNLNELRSVLHSLKVKIKIAQNKDHPKFYLWSKPWEKINMSHNVKDLLDNQQNKSDIKDKSLCSNQTYVNYTEDEMSTHNDIELSLKKLLNCSTDSLKRETDNKIFDDSLSEVADIKDVNSSQQTAQDLLKILEGTDILKHSETETLVTESQESDMSKEKLLNTEYSKLDLNSLLVNTNIDSVNVDIDLKTERGTSVNDLTATINPNELEAVLRSDLSEDKVLTPLDEHSKSAFYDTIKSENKSISFTTDATDVSMHSGVISSGEVSDGELMSQALAGELLSSPTTALNLNFTQSDIDTIEKSIRIPEAPVPEAKIEPEVCRQNLIDNIRHYQQLVKERMNAVEEEIAVLEAQDPTPENEGNINETVTMMLRDLSQMQKLAALY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00004710;
90% Identity: iTF_00004667;
80% Identity: iTF_01050424;