Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2.3 3.9e+04 -3.6 0.2 10 18 9 17 8 23 0.61

2 3 0.31 5.3e+03 -0.9 2.3 4 15 104 115 95 126 0.69

3 3 4.3e-24 7.5e-20 72.3 10.7 3 69 228 294 226 295 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2.3	3.9e+04	-3.6	0.2	10	18	9	17	8	23	0.61
2	3	0.31	5.3e+03	-0.9	2.3	4	15	104	115	95	126	0.69
3	3	4.3e-24	7.5e-20	72.3	10.7	3	69	228	294	226	295	0.96

Coding Sequence: ATGGAACAGGAACATAAAGATTCTCATTGTGAAAACGTAACAACTACAGACGAACAAAAACCTTCCACATCTGAAAACGTGCAAGAAGATCGACCAAACGatgataacattaaaaaaagaacggttaaacaaataatagatgAAGTATTAAATTGCACAGTTATCCACGTACCTAAACCGCAACAAACTGAATctacacaaaaattaaacaaagccGTAGTAAAATCTTCTACCAAGATAGTAACAGTTAAAGAAATATTAGGAGAAATTTTACAATACAATGTATGTAATCAATTTCAAGCATCGTCCACATCGCTTGATTGTTGTAATTGTGGATGTGATATTCCTCCTTATACACCGAGTACATCTGCTGAACAAAAAACTCGATCAGATCTAGATGTAACTCTTGTAAAGGAGGCTCCTTATTATAGaccatttcaaatttattcatCTGGTACATTACAAGattccatttttaaaactgaTTCGTTTTTACCGGCCAACATCACTCACTTACTTCCTACTTATTCTACGGTATTAAGACAAGGACCACCACCAAATATCAAATCAGCAGACTCATTTGTTCCAAAACTTCCTCCTCCTTCATACGCAGAAGTCGAAGGTTTATGGGATGATGTACCAAGCGCAGTATCTTCAGATTCCGTAATGTTCGGACCGGATCCTCTATATCTGATTTGTCCAGTTTGTAGAATTATAGTAATGACTGATGTAGAAAGAGAACGAAGTGCGATCACTCACTGGATTGCTTTGATATTATGTCTTTTCCTCTGTTGGCCTTGTTGCTTGTTGCCCTACTATATGAAATCTTGTAGTTACTCGTATCACAGCTGCCCTAACTGCAGCCACTATTTTGGTATGTATAATCCGTTTTAG
Protein Sequence: MEQEHKDSHCENVTTTDEQKPSTSENVQEDRPNDDNIKKRTVKQIIDEVLNCTVIHVPKPQQTESTQKLNKAVVKSSTKIVTVKEILGEILQYNVCNQFQASSTSLDCCNCGCDIPPYTPSTSAEQKTRSDLDVTLVKEAPYYRPFQIYSSGTLQDSIFKTDSFLPANITHLLPTYSTVLRQGPPPNIKSADSFVPKLPPPSYAEVEGLWDDVPSAVSSDSVMFGPDPLYLICPVCRIIVMTDVERERSAITHWIALILCLFLCWPCCLLPYYMKSCSYSYHSCPNCSHYFGMYNPF

Sequence clustering based on sequence similarity using MMseqs2