Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.6 1.3e+03 -0.2 0.0 71 81 5 15 2 22 0.76

2 3 8.6e-08 7.1e-05 23.1 0.1 41 82 75 111 60 117 0.82

3 3 2.7 2.2e+03 -0.9 0.6 41 57 170 185 150 192 0.77

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.6	1.3e+03	-0.2	0.0	71	81	5	15	2	22	0.76
2	3	8.6e-08	7.1e-05	23.1	0.1	41	82	75	111	60	117	0.82
3	3	2.7	2.2e+03	-0.9	0.6	41	57	170	185	150	192	0.77

Coding Sequence: ATGCGCGTTGAGAACGTGAAAGGCGCTGTATGGACAGTAGATGAAATTGAATTCTACAAAAGGAGACCACAGCGTACAACGATCACAACGACAGCGGCTCCAATTACCGCTGCAGAGGCGGCAATGTCAACAACTGACAGAGGCTTTGCGATCAATGGCGATGGGATCAATAAAAACGCTTCTTGTAACGTAATCAGTGGAGAAAGCAGTAGCAGTGTGAATAGCAATGGCAGCAGTAAATATACCAATGCCATACGCACAAACCTGTCGCTGCATAAATGTTTTGTGCGCTATGAAGATGACTTTGGCTCCTTTTGGATGGTAGACGACAGTGAATTTGTAAAACGACGACATTTATCGCGTGGCCGTCCGCGCAAATATGAACCGTCTTCATCGCCTAACTCCAACTCGCAGACGTCCGATAGTGCCGCTCCAATTGAGAAGAGCAGTAATAGTAACTGTAATAGAGCCATTGGCGACACTGTTGGTTCACAGAAATTATGGAATAAACAGCAAGAACAACATAAGCAGCACATAATTCATAATCTCAACCACTACCATTTCAGCCATCAGGATGATGATGGTGTCGGCGTCGATAGTAATAGTTTTGACAGCATGGGTAATGAAACGAGTATTGCGAACTGTGATGGCTGTCATAGTCATCACCCAAGTGCTGCTTTTGTTACTGGTACGCCAGTTGTGGCAGTTGCAATCGATATAGTTCGAGCAAGTGATAATAAATCAAGCCAAAatagaaacaacaataacagcaacgaCAACAAGTAA
Protein Sequence: MRVENVKGAVWTVDEIEFYKRRPQRTTITTTAAPITAAEAAMSTTDRGFAINGDGINKNASCNVISGESSSSVNSNGSSKYTNAIRTNLSLHKCFVRYEDDFGSFWMVDDSEFVKRRHLSRGRPRKYEPSSSPNSNSQTSDSAAPIEKSSNSNCNRAIGDTVGSQKLWNKQQEQHKQHIIHNLNHYHFSHQDDDGVGVDSNSFDSMGNETSIANCDGCHSHHPSAAFVTGTPVVAVAIDIVRASDNKSSQNRNNNNSNDNK

Sequence clustering based on sequence similarity using MMseqs2