Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 9.6e-10 2e-05 26.8 2.3 4 69 50 113 47 114 0.70

2 2 0.25 5.2e+03 -0.2 0.5 7 15 325 333 320 338 0.68

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	9.6e-10	2e-05	26.8	2.3	4	69	50	113	47	114	0.70
2	2	0.25	5.2e+03	-0.2	0.5	7	15	325	333	320	338	0.68

Coding Sequence: ATGCCGCCTATATTAAATGAAGCCAAAATTAGTTATGGAGACCCCTTGCAAGCAATGTATTCTCGGCCACACAAACAAAAGCCAAAGCAATCGAATAAGTTTCCTAAGACCATGTTCATCAAACGAAACCATTTACCACGTGATCCACCAATTATGACCTGCAATAATTGCCTATATCCCATACCGAAAACATTGAAAGTTAGTTATGTCAATGGATATACTCATTTAGTGGCCGCTTTTATGACGCCAGTCCTACTCACATGGATGCCCTATACTTTTCGATTTACTAAGACGATTGTTCATCACTGTCCATTTTGTCACGTGCAGCTTGGTGTAACCGAATTCAAGCCGTTCAGCAAAGCTAAGAAAGAAAAGAGACTCAAGTTGAAGTTCCAACATCCTACCGAGTCTAGAGGGCGATTAGTTGATGCTGCCACACCAAGTCGCCCTCCTGTTAGACGAGTTTCTTCGCGAGAGAGTTTGAAATTCTTGCAATATACTGTAATAGATGAGTCGGCAAACTTACGGGATCATATGCGACCGTTGCACGTCGCCAGCTCTGTCAAATCATCTATTACACCATTCAATCTGCTCGCAGAAGCTGTATCAAGTTCGCAACTTGTTCCATTGGTTCGTAGAGCTAACATAAATCCAAACGCTCCTCCGTCATCGGAAGGGGCTTCAGCCAAAGTCAAATTTGACACGAAAACTCCCCGAGCTGTTGCATCGTTTTTAAGTATGAAAACTGCTGAAAGCGGATCGTCGAAGGGAAAGTCAGAGGCTGAAATTGCAGCACACTGTCTCTATACAGCTATACCAAAAAGCGGGTGCCGATTTATGCCACAAACCCCTAACGATAGTAAAAAAGCAACACCAAGACCTAGTCGCAAAGGATCGGGAACTGAGATACCTCATGAGAGTGCCTCAACTGAAGACTTGGAAAAACGAACAGACAAAGCGGCAAAGTATAAGAAATGTAAAAAATGCCATAGGCATAAGAAACCTAAGAAACAAGACCCCGACCTGGCGCTTGATGTAGACAGTTAG
Protein Sequence: MPPILNEAKISYGDPLQAMYSRPHKQKPKQSNKFPKTMFIKRNHLPRDPPIMTCNNCLYPIPKTLKVSYVNGYTHLVAAFMTPVLLTWMPYTFRFTKTIVHHCPFCHVQLGVTEFKPFSKAKKEKRLKLKFQHPTESRGRLVDAATPSRPPVRRVSSRESLKFLQYTVIDESANLRDHMRPLHVASSVKSSITPFNLLAEAVSSSQLVPLVRRANINPNAPPSSEGASAKVKFDTKTPRAVASFLSMKTAESGSSKGKSEAEIAAHCLYTAIPKSGCRFMPQTPNDSKKATPRPSRKGSGTEIPHESASTEDLEKRTDKAAKYKKCKKCHRHKKPKKQDPDLALDVDS

Sequence clustering based on sequence similarity using MMseqs2