Basic Information

Insect: Nematopogon swammerdamellus
Gene Symbol: Poxn
Assembly: GCA_946902865.1
Location: CAMPPV010000043.1:63155-68280[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 6.2e-20 2.6e-16 60.6 0.1 73 125 17 69 14 69 0.97

2 7 4.1e-15 1.7e-11 45.0 0.0 82 125 88 131 75 131 0.94

3 7 3.5e-16 1.5e-12 48.4 0.0 82 125 150 193 137 193 0.94

4 7 3.5e-16 1.5e-12 48.4 0.0 82 125 212 255 199 255 0.94

5 7 3.5e-16 1.5e-12 48.4 0.0 82 125 274 317 261 317 0.94

6 7 5.8e-16 2.5e-12 47.7 0.0 82 125 336 379 323 379 0.94

7 7 7.3e-15 3.1e-11 44.2 0.0 82 125 398 441 385 441 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	6.2e-20	2.6e-16	60.6	0.1	73	125	17	69	14	69	0.97
2	7	4.1e-15	1.7e-11	45.0	0.0	82	125	88	131	75	131	0.94
3	7	3.5e-16	1.5e-12	48.4	0.0	82	125	150	193	137	193	0.94
4	7	3.5e-16	1.5e-12	48.4	0.0	82	125	212	255	199	255	0.94
5	7	3.5e-16	1.5e-12	48.4	0.0	82	125	274	317	261	317	0.94
6	7	5.8e-16	2.5e-12	47.7	0.0	82	125	336	379	323	379	0.94
7	7	7.3e-15	3.1e-11	44.2	0.0	82	125	398	441	385	441	0.94

Sequence Information

Coding Sequence: ATGCCGCTAGCGTCCTCGGAACCGTGCCCATATCGTCTCGTCTGGAGGAGGCAAGTGGCGACGCCCACAGTCGTCAAGAAGATACTGCGCCTGAAGCAGGAGAACCCGGGCATGTTCGCGTGGGAGATCCGCGAGCGGCTGCTCAGCGCGCGCGTGTGCGAACCCCACTCCATACCTTCGGTGTCGTCCGTCAACCGCATACTGAGGAACAGCGGCGCGTGGAGCGACGCCGAGCTGGTAGCACCGCACGGCCATAGAGGTAAGAAGATACTCCGCCTGAAGCAGGAGAACCCGGGCATGTTCGCGTGGGAGATCCGCGAGCGGCTGCTCAGCGCGCGCGTGTGCGAACCCCACTCCATACCTTCGGTGTCGTTCGTCAACCGCATACTGAGGAACAGCGGCGCGTGGAGCGACGCCGAGCTGGTAGCACCGCACGGCCATAGAGGTAAGAAGATACTCCGCCTGAAGCAGGAGAACCCGGGCATGTTCGCGTGGGAGATCCGCGAGCGGCTTCTGAGCGCGCGCGTGTGCGAACCCCACTCCATACCTTCGGTGTCGTCTGTCAACCGCATACTGAGGAACAGCGGCGCGTGGAGCGACGCCGAGCTGGTAGCTCCGCACGGCCATAGAGGTAAGAAGATACTCCGCCTGAAGCAGGAGAACCCGGGCATGTTCGCGTGGGAGATCCGCGAGCGGCTGCTCAGCGCGCGCGTGTGCGAACCCCACTCCATACCTTCGGTGTCGTCCGTCAACCGCATACTGAGGAACAGCGGCGCGTGGAGCGACGCCGAGCTGGTAGCACCGCATGGCCATAGAGGTAAGAAGATACTCCGCCTGAAGCAGGAGAACCCGGGCATGTTCGCGTGGGAGATCCGCGAGCGGCTTCTGAGCGCGCGCGTGTGCGAACCCCACTCCATACCTTCGGTGTCGTCTGTCAACCGCATACTGAGGAACAGCGGCGCGTGGAGCGACGCCGAGCTGGTAGCTCCGCACGGCCATAGAGGTAAGAAGATACTCGGCCTGAAGCAGGAGAACCCGGGCATGTTCGCGTGGGAGATCCGCGAGCGGCTTCTGAGCGCGCACGTGTGCGAACCCCACTCCATACCTTCGGTGTCGTCTGTCAACCGCATACTGAGGAACAGCGGCGCGTGGAGCGACGCCGAGCTGGTAGCACCGCACGGCCATAGAGGTAAGAAGATACTCCGCCTGAAGCAGGAGAACCCGAGCATGTTCGCGTGGGACATCCGCGAGCGGCTGCTCAGCGCGCGCGTGTGCGAACCCCACTGCATACCTTCAGAGTCCTCCGTCAACCGGATACTGAGGAACAGCGGCGCGTGGAGTGACGCCGAGCTGGTAGCTCCGCACGGCCATAGAGATTCGTACCAACCATCTGAGATGCCTCCAAACTCGGCCGAGTACCCACACCAGCTAAAGAACACTCTACCTGCACCTCAAAACCAGCCGCCTTACTTCCCCCACTCGGCTGTCAGACTGCCGACATCCCCTCAAGATCCCCCTCCTCCAAATTTCTACGAAAGACGCCTGGCGACATCGTGGCTTCTCGCAAACCAAGTGCAAAACGCTCAGGGTCTACTGAAACCCTACCCAGTCAACCCCTGGCATAGAATCATGATGCCGTGCCATCTTCCGGATTCAAAAAACGCATTTGTCCCCTACGCAAACGCGATCAACCTCCACACGGACATTTTCAACAGGCTACACTATCTCAGTGTCAATTCGGAGAGTGATATCAAATCAGAATGCAGATCAGAACTCATTTCTATCGACGCCAGCGACGATAGTGTCGATAAGCGATCGGAAATGGACGAAGACGAGAGAAAAACGCCAAAAACGAACGAGAAGAAGAAAAATCCGTATTCGATAGAGGAGTTGCTGAAAAAACCGGATAAGATAGCTACAAATCCTTGTGTCGGTACGGCTTTTCTGAGGCAACCGAGTGGCAGTATGGTAGAGCCGGGCGACAAAGCGCACAGCAATCGAAGTTCTCCGGATAGTTTTTGCTCGGTTCAGAGCAGTTCATCTAATGATGCTTTTCGCAATACTGATAATTAG
Protein Sequence: MPLASSEPCPYRLVWRRQVATPTVVKKILRLKQENPGMFAWEIRERLLSARVCEPHSIPSVSSVNRILRNSGAWSDAELVAPHGHRGKKILRLKQENPGMFAWEIRERLLSARVCEPHSIPSVSFVNRILRNSGAWSDAELVAPHGHRGKKILRLKQENPGMFAWEIRERLLSARVCEPHSIPSVSSVNRILRNSGAWSDAELVAPHGHRGKKILRLKQENPGMFAWEIRERLLSARVCEPHSIPSVSSVNRILRNSGAWSDAELVAPHGHRGKKILRLKQENPGMFAWEIRERLLSARVCEPHSIPSVSSVNRILRNSGAWSDAELVAPHGHRGKKILGLKQENPGMFAWEIRERLLSAHVCEPHSIPSVSSVNRILRNSGAWSDAELVAPHGHRGKKILRLKQENPSMFAWDIRERLLSARVCEPHCIPSESSVNRILRNSGAWSDAELVAPHGHRDSYQPSEMPPNSAEYPHQLKNTLPAPQNQPPYFPHSAVRLPTSPQDPPPPNFYERRLATSWLLANQVQNAQGLLKPYPVNPWHRIMMPCHLPDSKNAFVPYANAINLHTDIFNRLHYLSVNSESDIKSECRSELISIDASDDSVDKRSEMDEDERKTPKTNEKKKNPYSIEELLKKPDKIATNPCVGTAFLRQPSGSMVEPGDKAHSNRSSPDSFCSVQSSSSNDAFRNTDN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -