Nswa013907.1
Basic Information
- Insect
- Nematopogon swammerdamellus
- Gene Symbol
- FOXL3
- Assembly
- GCA_946902865.1
- Location
- CAMPPV010000442.1:34803-45595[-]
Transcription Factor Domain
- TF Family
- Fork_head
- Domain
- Fork_head domain
- PFAM
- PF00250
- TF Group
- Helix-turn-helix
- Description
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 5 1.7e-15 3.5e-12 47.1 0.0 34 81 34 78 32 83 0.92 2 5 4.8e-14 1e-10 42.5 0.1 33 77 95 136 91 137 0.92 3 5 3.8e-15 8.1e-12 46.0 0.1 34 82 137 182 135 186 0.91 4 5 5.7e-16 1.2e-12 48.6 0.0 33 82 198 244 194 248 0.91 5 5 5.7e-16 1.2e-12 48.6 0.0 33 82 260 306 256 310 0.91
Sequence Information
- Coding Sequence
- ATGGTGGCGCGCAGCGCCTGGTACGGCCGCGAGCGGACCACTCCGCGCTTCATTGAACATCGCTCACCTGCGGGTCGAGGGGGCCGCCGCCGCCGGGGGGACCGCTTCCCCTACTACAAGGCGAACGACGAGGGCTGGAAGAACTCGGTGCGGCACAACCTGTCGATCAACCCGCACTTCCGCAAGGGCGGCCGCGCGCCGCACGGCGCAGGAGACCTCTGGTCGCTCGCCGCCTACGCTATAGATCTGTTGCCGCTGCGCAATAACAAAGTGTTTGCCAACAGGGACCGCTTCCCCTACTACAAGGCGAACGACGAGCGCTGGAAGAACTCGGTGCGGCACAACCTGTCGATCAACCCGAACTTCCGCAAGGGCGGCCGCGCGCCGCACGGCGCAGGAGACCTCTGGGAGCGCTTCCCCTACTACAAGGCGAACGACGAGCGCTGGAAGAACTCGGTGCGGCACAACCTGTCGATCAACCCGCACTTCCGCAAGGGCGGCCGCGCGCCGCACGGCGCAGGAGACCTCTGGTCGCTCGCCGCCAACGCTATAGATCTGTTGCCGCTGCGCAATAACAAAGTGTTTGCCAACAGGGACCGCTTCCCCTACTACAAGGCGAACGACGAGCGCTGGAAGAACTCGGTGCGGCACAACCTGTCGATCAACCCGCACTTCCGCAAGGGCGGCCGCGCGCCGCACGGCGCGGGACACCTCTGGTCGCTCGCCGCGAACGCTATAGATCTGTTGCCGCTGCGCAATAACAAAGTGTTTGCCAACAGGGACCGCTTCCCCTACTACAAGGCGAACGACGAGCGCTGGAAGAACTCGGTGCGGCACAACCTGTCGATCAACCCGCACTTCCGCAAGGGCGGCCGCGCGCCGCACGGCGCGGGACACCTCTGGTCGCTCGCCGCGAACGCTATAGATCTGTTGCCGCTGCGCAATAGCTATCCCAACGTGATCGTCCTGGACGAGGCGGCTATAGCGGCGGCCAGCATCATGCCCCACGTCGAATACGTTTCTGGAGTTAACGCGGCCTTCCTGAACCCGGTGTCGGCGGAGGAAGTCGTGTACGAGAGCGGCCTGCTGCTGTCCGCCGATTAG
- Protein Sequence
- MVARSAWYGRERTTPRFIEHRSPAGRGGRRRRGDRFPYYKANDEGWKNSVRHNLSINPHFRKGGRAPHGAGDLWSLAAYAIDLLPLRNNKVFANRDRFPYYKANDERWKNSVRHNLSINPNFRKGGRAPHGAGDLWERFPYYKANDERWKNSVRHNLSINPHFRKGGRAPHGAGDLWSLAANAIDLLPLRNNKVFANRDRFPYYKANDERWKNSVRHNLSINPHFRKGGRAPHGAGHLWSLAANAIDLLPLRNNKVFANRDRFPYYKANDERWKNSVRHNLSINPHFRKGGRAPHGAGHLWSLAANAIDLLPLRNSYPNVIVLDEAAIAAASIMPHVEYVSGVNAAFLNPVSAEEVVYESGLLLSAD
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -