Basic Information

Gene Symbol
Dis3
Assembly
GCA_963924495.1
Location
OZ004638.1:6094852-6107341[+]

Transcription Factor Domain

TF Family
CSD
Domain
CSD domain
PFAM
PF00313
TF Group
Beta-Scaffold Factors
Description
In molecular biology, the cold-shock domain (CSD) is a protein domain of about 70 amino acids which has been found in prokaryotic and eukaryotic DNA-binding proteins. When Escherichia coli is exposed to a temperature drop from 37 to 10 degrees Celsius, a 4–5 hour lag phase occurs, after which growth is resumed at a reduced rate.During the lag phase, the expression of around 13 proteins, which contain cold shock domains is increased 2–10 fold. These so-called 'cold shock' proteins are thought to help the cell to survive in temperatures lower than optimum growth temperature, by contrast with heat shock proteins, which help the cell to survive in temperatures greater than the optimum, possibly by condensation of the chromosome and organisation of the prokaryotic nucleoid.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 0.6 8.1e+03 -2.5 0.1 27 54 91 116 64 118 0.54
2 5 1.3 1.7e+04 -3.5 0.0 17 36 178 197 167 202 0.74
3 5 0.14 1.9e+03 -0.5 0.0 20 33 278 291 267 306 0.82
4 5 0.9 1.2e+04 -3.0 0.0 41 50 335 346 317 349 0.65
5 5 2.1e-08 0.00028 21.4 0.0 3 71 371 438 370 441 0.84

Sequence Information

Coding Sequence
ATGTGGACAACAAAAACTTTCCTAACAAAAACGAAGCGCGGTAACATTTTGAAGATTGTTAGAGAACATTACTTGCGCGATGATTTATTGTGTGGCTCTGCTGCATGCAAACAATGCCCCCATAAGAATAATGAGACAGTTCTTGACATTGTACCAGACTCAATATGTGCACTGTTTGATTACCCTCATTATGTGGTGTTGGACACAAATGTGGTTTTGCATCAAATTGATGTATTGGAAGAGGATGCTTTGTCTAATGTGATTATTTTACAAACTGTACTTGAGGAAGTAAAACATCAAAACACTGCTATACTACAAAGACTTTTAGAAATCATTGGCAAAAAGAATAGGAAATTTTATTCATTTGTGAATGAACATCACAAAGATACATATGTGGAGCGTCAACCCGGTGAGaaacaaaattatagaaacGATCGTGCTATCAGAAGGACAGCAGCATGGTATTCTGCACACTTGTCAATCAATGGTGTTGAAGGAAAGATTCCGAAAGTAGTTTTGTTAACTGATGACGAAAACAACAGGAAGTTGGCACAGGAAGAAGGCATTGTTTGTTGCTCAGtgaAAGACTATATAGAAAATGTGAATGGCTTCCCTGGACTTATGGATAAGCTATCCAAGAATATAATGCCAGAGAGTTTCTCCAAAGATGCATTGTATCCTGCTCATTTGACTCCTACCCAAGTTCACTCTGGTATTAGGAACAATAAATTGTATCAAGGCACTTTTCATGCTTCAAGGGACAATTTCTTGGAAGGCACTGCTATGGTTTCCGGTTTTGAAAAATctATATTGCTTCAAGGCCACATAGGAATAAACAGAGCTGTCGATGGCGACATAGTTGCTATAGAAGTATTCCCTCCAGAAGAATGGAGCAGACCAAGCAACATTGTTCTAGAAGACAAACAGGATGATCCTGGAGATCTCTTGGAAGAAGAAACTTTGTTAGCAGAAACAACTAAACCTATAGGTGACAATGATGATGATGTGACACCAACAGGGAAAGTTGTTGGTATCATTAGAAGAAAATGGAGACAATATTGTGGTATACTTCAACCAAGCAAATTTCCTGGTGCAACACGCCATCTGTTCGTTCCGGCTGAAAAGAAAATACCGCGCGTCAGAATTGAAACCCGTCAGAGCGATTTATTGGCTTCACAAAGGATACTTGTGGCTCTGGACTCTTGGCCACGTAATAGTCGATATCCTTTAGGTCATTTCGTGAGAGCACTTGGTCCTATTGGAGATAAGGATGCAGAAAATGAAGTTCTATTACTGGAACATGATGTACCTCATGCCAGGTTTAGTGAAGCGGTGTTGGCATGTTTACCACCAAATGACTGGACCATAACACAAGagGAAGTCAACAAACGCGTCGACCTGCGCTCTATATGCGTTTGTTCCGTCGACCCGCCCGGTTGTACTGACATAGATGACGCTTTGCATGCTAAACCTATTTCTGGCACCACCCTTGATGGCCATAAGAAGTATGAAGTAGGCGTCCATATAGCGGATGTGACACATTTTGTTCGACCGAATACGGCTTTGGATAAAGAGGCGGCACTACGCTCCACGACTGTGTATTTGGTTGACAAGAGAATTGATATGGTGCCAGATTTATTAAGTTCAAACTTGTGTTCGCTGCGTGGTGGTGAAGAGCGGCTGGCGTTTTCTTGTGTTTGGGAAGTTGATGAAAATGCCAATGTGCTGAGTACCAAATTTCATAAAAGTGTTATCaagTCTCGGTCAGCTATGACTTACGAAGAAGCACAAATAGCGATCGACGACAAAAGACGCGACGACGAGATTGCTTCGTCGTTACGCATATTGAATATATTAGCCAAGAAGTTGAAGAAGAAACGTTTAGACAACGGAGCGTTGTTGCTAGCTTCACCTGAAATACGATTCCAGGTTGATTCCGAAACTCACGATCCGATTGAAGTGCAAGCGAAAAAAGTTCGCGACACGAATTCGATGGTGGAGGAGTTCATGTTGTTGGCCAATGTTAGCGTAGCTGAGCGACTCGCAGCAGACTTCCCGCAGTGCGCGCTACTTAGAAGACATCCGTCACCGCCGCCAGCTAACTTTACGACATTCCTAAAGGCTGCTAAACAACAGGGTTTCGAGTTGGACGTATCAACTAACGCCGCGTTTTCCAAGTCACTAGACACAGCTGTGATACCCGGCCGGCCGTTCTTCAACACTCTACTGCGGATCATGGCGACGCGTTGTATGCAGCAGGCAGTTTACTTCTCTAGCGGGACTAAGTCTCAGGAGGAATTTTATCATTATGGCTTGGCATGTCCCATATACACGCATTTCACGTCGCCTATTAGAAGATACGCCGACGTAATAGTTCACCGCCTGTTGGCTGCCACAATCGGTGCCGATGCGACTCATGCTACCTTACTGGACACCAAAGTGGCGGACGCGGTCTGTGACAATTTGAACTACCGACATCGACAAGCCCAGTACGCTGGACGGGCTTCCGTGGCACTCAACACACATattttgtttaaaaacaGAGTTGAAATTGAATCAGCAGTGGTATTGGCGGTGAAAAGGAACGCTCTCCAAGTACTCATACCTAAGTATGGACTCGAGGGGCCTTTGTATCTACCTGCCGACATGTTCACATATAATGAAGAGGAGCATTACCAAGTTTGCGGCAATGTGACATTGAAAACTTTTGATGAATTAACTGTCAGGTTAAGTCTGGACAGTACAAATTTGCAGCACAGAAAACTGATGTTCCAACTAGTTGAGCCGCATATTCCTGACTTTAGTTTTGTACCAGAGGATCAGAAAAATGACAATATGGAAGTAGATACTGGTGTCAAAGATTTGGGTAAAGACACGAATGGAAAGAGGAAAGATGGACCAAGCAATAAGAGTGCTAagaaaaaatccagaaataaataa
Protein Sequence
MWTTKTFLTKTKRGNILKIVREHYLRDDLLCGSAACKQCPHKNNETVLDIVPDSICALFDYPHYVVLDTNVVLHQIDVLEEDALSNVIILQTVLEEVKHQNTAILQRLLEIIGKKNRKFYSFVNEHHKDTYVERQPGEKQNYRNDRAIRRTAAWYSAHLSINGVEGKIPKVVLLTDDENNRKLAQEEGIVCCSVKDYIENVNGFPGLMDKLSKNIMPESFSKDALYPAHLTPTQVHSGIRNNKLYQGTFHASRDNFLEGTAMVSGFEKSILLQGHIGINRAVDGDIVAIEVFPPEEWSRPSNIVLEDKQDDPGDLLEEETLLAETTKPIGDNDDDVTPTGKVVGIIRRKWRQYCGILQPSKFPGATRHLFVPAEKKIPRVRIETRQSDLLASQRILVALDSWPRNSRYPLGHFVRALGPIGDKDAENEVLLLEHDVPHARFSEAVLACLPPNDWTITQEEVNKRVDLRSICVCSVDPPGCTDIDDALHAKPISGTTLDGHKKYEVGVHIADVTHFVRPNTALDKEAALRSTTVYLVDKRIDMVPDLLSSNLCSLRGGEERLAFSCVWEVDENANVLSTKFHKSVIKSRSAMTYEEAQIAIDDKRRDDEIASSLRILNILAKKLKKKRLDNGALLLASPEIRFQVDSETHDPIEVQAKKVRDTNSMVEEFMLLANVSVAERLAADFPQCALLRRHPSPPPANFTTFLKAAKQQGFELDVSTNAAFSKSLDTAVIPGRPFFNTLLRIMATRCMQQAVYFSSGTKSQEEFYHYGLACPIYTHFTSPIRRYADVIVHRLLAATIGADATHATLLDTKVADAVCDNLNYRHRQAQYAGRASVALNTHILFKNRVEIESAVVLAVKRNALQVLIPKYGLEGPLYLPADMFTYNEEEHYQVCGNVTLKTFDELTVRLSLDSTNLQHRKLMFQLVEPHIPDFSFVPEDQKNDNMEVDTGVKDLGKDTNGKRKDGPSNKSAKKKSRNK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01501851;
90% Identity
-
80% Identity
-