Basic Information

Insect: Nebria salina
Gene Symbol: topi
Assembly: GCA_944039265.1
Location: CALUEJ010000139.1:2226654-2229033[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 0.00026 0.025 15.9 1.8 2 21 131 150 130 151 0.94

2 13 8.1e-05 0.0079 17.5 3.4 1 21 176 196 176 198 0.94

3 13 0.0038 0.37 12.2 0.9 2 23 205 226 205 226 0.95

4 13 0.028 2.7 9.5 0.1 2 20 245 263 244 265 0.89

5 13 0.0003 0.029 15.7 1.0 1 23 322 344 322 344 0.99

6 13 0.12 11 7.5 4.3 2 22 387 407 386 410 0.86

7 13 0.01 1 10.8 1.0 1 23 496 519 496 519 0.97

8 13 0.54 52 5.4 2.9 1 23 523 545 523 545 0.92

9 13 7.6e-07 7.3e-05 23.9 2.4 1 23 551 573 551 573 0.98

10 13 0.026 2.5 9.6 0.2 1 23 579 604 579 604 0.96

11 13 0.46 44 5.7 3.3 1 23 610 632 610 632 0.86

12 13 1.6e-05 0.0016 19.7 0.5 3 23 640 660 638 660 0.97

13 13 2.1e-06 0.00021 22.4 0.3 1 23 666 689 666 689 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	0.00026	0.025	15.9	1.8	2	21	131	150	130	151	0.94
2	13	8.1e-05	0.0079	17.5	3.4	1	21	176	196	176	198	0.94
3	13	0.0038	0.37	12.2	0.9	2	23	205	226	205	226	0.95
4	13	0.028	2.7	9.5	0.1	2	20	245	263	244	265	0.89
5	13	0.0003	0.029	15.7	1.0	1	23	322	344	322	344	0.99
6	13	0.12	11	7.5	4.3	2	22	387	407	386	410	0.86
7	13	0.01	1	10.8	1.0	1	23	496	519	496	519	0.97
8	13	0.54	52	5.4	2.9	1	23	523	545	523	545	0.92
9	13	7.6e-07	7.3e-05	23.9	2.4	1	23	551	573	551	573	0.98
10	13	0.026	2.5	9.6	0.2	1	23	579	604	579	604	0.96
11	13	0.46	44	5.7	3.3	1	23	610	632	610	632	0.86
12	13	1.6e-05	0.0016	19.7	0.5	3	23	640	660	638	660	0.97
13	13	2.1e-06	0.00021	22.4	0.3	1	23	666	689	666	689	0.98

Sequence Information

Coding Sequence: ATGTGCGAAcaagaaaatacatttttgaaaatacatcGACTCGATCCAGACGGAATTGTTAATTCATCGATACGTCTAGAAATCGATTGTTCAAATCAGGTGATTACGAACACAGTGCTAACACCGgccgaaataaatttcgataaGCATATTTGCAACTGGGGTTATTTCGTGGACGATAAAATTAATCTGAATTACCGTCACGTAGAAGAAAATAATCCTACAATCACTGTCATTAAAGTGGGCGGCTTGGATGAATTGAACCCGATGAATTACATCACACATATTAACGCGACAATCAACGATTCGCTCGGCAAAGATAACTATGTATTCGAAGAAACGAAAAAGCAACaggtaaaacaaattaatttacccGATAATTCGGGCATTTCCTGTCAAAATTGCGATACGTCTTTCCCGACAAAGTATCAGTACCAACGGCACCAGTGCGAGTTCAACGCGGAGAAAGTAGTACTGAAACCGGAAGTGGCAGGAAAAGACCTAGACAAAGCGACTAGATTAAGATTCGAGTGTGACGTATGCAAAAAGTCATTTGTGAGTAATAACAATTTAGAGCGGCACAAGAATTGCCATAAGAATGATAGCAATAATGTTTGTGATTTCTGTAATAAATCGTTTGTGAGCGAAAATAGACTGAAAATCCACAAAGAGAATCATTGCAAAAAAGGGGGGGATATGACTAAGTTTTATCGGAGCGATGTAATTGTTTGGCAGTGCGATGAGTGCAAGCAAGTGTTTGCGAGTCAAGAAAACGGGAATAAACATGTTTTGAAATGTGTATTAGGACACCATTCTATAAAAGAGGACGAGGATGATAgttcaattttcaaattgaaaactGTTTTCGAGGAAAACAATTCCGATTCCAATCAAAGTCAATCAGATACAATGTTTAAAGATAGCGAAtcaaatagtttatttaaaatagtaacaGAAATGTTATATCAATGCGAATATTGCAATCGCACATACGCAGACAAATCCATTGTTTTAAACCACCAAAAAACGCATAGCACCGATAAAAACTACGAATGCATTTTTTGCGACACGCATTTCGACAATTACCAACTAGCCACAATCCATTGgcaaaataaatgcaataacGAGTCAAATGTTTTCTATCTACCGAAAATGATATATTGCGAACACTGTGACCGCAGTTTTAAATCACATGAGATTTTATACAATCACAAAAATAAGAAACGACATTTTACGCCGAAAATCCATTTGAAAACGGAAGAAAACTACAGCGGAATTAGAAGTGACAACGAGCGAGCAATTGTCAAGTTGATTGAGAATATGATTTCGAAAATGGACCAAGCCCTGTCCAGTGCTGAGCAAGCagtgaaaattgaaaatggcGAAGCGCATCCAGTGATTGGCAAGAAGAAGCGTGGACGCAAACGTAAAAATCAAAAGACTGAATTGAAGTATCAAAAGTCTGTGTATGAAGATGGGTATCAGTATCAGTGCGAGAGGTGCCCGATGGTTTTTCGGAGTATTTTGTGTTTGATTTCACATAAAGAAACTGAACACGCTGCTACGTTTTGCTGTGAACAATGTGGACAGgTCGTTCACAGTGCGAAAGCTTTAATGATCCATTGCCGAGCCCATCAAAGCCTCAAGCCTTACGTTTGCGACCAATGTGGTCGCAGTTATTCACAAACTTCCCACCTGTGGCAGCACATGCGTTTCCATCAAGGGATCAAGCCGTTTGCGTGCCCGCACGAAGGTTGCGAGGCACGCTATACAATTCGACCAGATTTGAAAGATCACATCCGAAAAGTGCACACACGAGAACGTCCATTTAAGTGTTCCGTGTGCCAGAAGTGTTTCTTGACGGGTTCTGTGTATTACCAACACCGATTGATTCACACGAATGATCGACGATACGGCTGCGAAGTGTGCAATAAACGTTTTTTTCGTGCAGATGCCCTGAACAACCACCGTCGAATTCACACGGACGAACGACCGTATCCTTGTCCGGTTTGCGGACGCGAGTTCCGCCAAAAAGGCGACCGCAACAAACATGTTCGTACGCAACACTCGGTTTAA
Protein Sequence: MCEQENTFLKIHRLDPDGIVNSSIRLEIDCSNQVITNTVLTPAEINFDKHICNWGYFVDDKINLNYRHVEENNPTITVIKVGGLDELNPMNYITHINATINDSLGKDNYVFEETKKQQVKQINLPDNSGISCQNCDTSFPTKYQYQRHQCEFNAEKVVLKPEVAGKDLDKATRLRFECDVCKKSFVSNNNLERHKNCHKNDSNNVCDFCNKSFVSENRLKIHKENHCKKGGDMTKFYRSDVIVWQCDECKQVFASQENGNKHVLKCVLGHHSIKEDEDDSSIFKLKTVFEENNSDSNQSQSDTMFKDSESNSLFKIVTEMLYQCEYCNRTYADKSIVLNHQKTHSTDKNYECIFCDTHFDNYQLATIHWQNKCNNESNVFYLPKMIYCEHCDRSFKSHEILYNHKNKKRHFTPKIHLKTEENYSGIRSDNERAIVKLIENMISKMDQALSSAEQAVKIENGEAHPVIGKKKRGRKRKNQKTELKYQKSVYEDGYQYQCERCPMVFRSILCLISHKETEHAATFCCEQCGQVVHSAKALMIHCRAHQSLKPYVCDQCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFKCSVCQKCFLTGSVYYQHRLIHTNDRRYGCEVCNKRFFRADALNNHRRIHTDERPYPCPVCGREFRQKGDRNKHVRTQHSV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01040326;
90% Identity: iTF_01039577;
80% Identity: -