Basic Information

Insect
Nebria ingens
Gene Symbol
topi
Assembly
GCA_018344505.1
Location
JADQWA010001216.1:110803-113306[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.00017 0.013 15.9 1.8 2 21 131 150 130 151 0.94
2 13 2.8e-05 0.0023 18.3 3.4 1 21 176 196 176 198 0.94
3 13 0.0024 0.2 12.2 0.9 2 23 205 226 205 226 0.95
4 13 0.02 1.6 9.3 0.1 2 20 245 263 244 265 0.89
5 13 2.1e-05 0.0017 18.7 1.0 1 23 324 346 324 346 0.99
6 13 0.076 6.1 7.5 4.3 2 22 389 409 388 412 0.86
7 13 0.0066 0.54 10.8 1.0 1 23 498 521 498 521 0.97
8 13 0.34 28 5.4 2.9 1 23 525 547 525 547 0.92
9 13 4.8e-07 3.9e-05 23.8 2.4 1 23 553 575 553 575 0.98
10 13 0.017 1.3 9.6 0.2 1 23 581 606 581 606 0.96
11 13 0.29 24 5.7 3.3 1 23 612 634 612 634 0.86
12 13 1e-05 0.00085 19.6 0.5 3 23 642 662 640 662 0.97
13 13 1.4e-06 0.00011 22.4 0.3 1 23 668 691 668 691 0.98

Sequence Information

Coding Sequence
ATGTACGAACAAGAAAATACATTTTTGAAAATACATCGACTCAATCCGGACGGAATTGTTAATTCATCTATACGTCTCGAAATCGATTGTTCAAATCAAGTGATTACGAACACAGTGCTAACGCAGGCCGAAATCAATTTCGATAAGCACATTTGCAACTGGGGTTATTTTGTGGACGATAAAATTAATCTCAATTACCGTCACGTAGAAGAAAATAATCCTACAATCACCGTCATTAAAGTTGGCGGATTGGATGAATTGACTCCGATGAATTATATCACACATATAAATGCGACAATCAATGATTCGCTTGGCAAAGATAACTATGTGTTTGAAGAAACGAAAAAGCAACAGGTAAAACGAATTAATTTACCCGATAATTCTGGCATCTCTTGTCAAAATTGCGATACGTCTTTCCCGACGAAGTATCAGTATCAGCGGCATCAGTGCGAGTTTAATGCCGAGAAAGTAGTATTAAAGCCGGAAGTAGCAGGAAAAGATCTAGACAAAGCGACTAGATTACGATTCGAATGTGACATATGCAAAAAGTCATTTGTGAGTAATAATAATTTAGAACGGCATAAGAATTGTCATAAGAATGATAGCCATAATGTTTGTGATTTCTGCAACAAATCGTTTGTGAGCGAAAATAGACTGAAAATTCATAAAGAGAATCATTGTAAGAAAGGTGGGGATATGACTAAGTTTTATCGGAGCGATGTGATTGTTTGGCAGTGCGATGAATGCAAGCAAGTGTTTGCAAGTCAAGAAAATGGCAATAAACATGTATCGAAATGTATATTAGCAAACCATTCAATAAAAGAGGACGAAGATGATACGTCCCTTTTCAAATTGAAAACCATTTACGAGGAAAACAATTCCGATTCAAATCAAAGTCAATCAGATACATCCGGTTTCTATAAAGATGGCGAATCGAATGGTCTATTCAAGATTGTAACGGAAATGTTATACCAATGCGAATATTGCAATCGCACATACGCAGACAAATCCGTTGTTTTAAACCATCAAAAAACACATAGCACTGACAAAAATTACGAATGTATTTTTTGTCACTCACATTTCGACAATTACCAACTTGCCACGATCCACTGGCAAAATAAATGCAATAACGAATCCAATGTTTTCTATCTACCAAAAATGATATATTGCGAACACTGTGACCGTAGTTTTAAATCACATGAGATTTTATACAATCACAAAAATAAGAAGCGACATTTTACACCGAAAGTCCATTTGAAAACGGAAGAAAACAATAACGAGATCAGAAGCGAAAATGAAAAAGCGATTGTCAAGTTGATTGAGAACATGATTTCTAAAATGGACCAAAATCTGTTTAATGCTGAGCAAGCAGTGAAAATTGAACATGGTGACACTACTCCAGTGGTTGGTAAGAAAAAACGTGGACGTAAGCGTAAAAATCAAAAGACTGAACTGAAATACCAAAAGTCTGTGTATGAAGATGGCTATCAGTATCAGTGCGAGAGGTGCCCGATGGTTTTTAGGAGTATTTTGTGTTTGATTTCGCATAAAGAAACTGAACATGCTGCTACGTTTTGTTGTGAACAATGTGGACAGGTAGTTCACAGCGCAAAAGCCTTAATGATCCATTGCCGAGCCCATCAAAGCCTCAAGCCTTACGTTTGTGACCAATGTGGTCGCAGTTATTCACAAACTTCCCACCTGTGGCAGCACATGCGTTTCCATCAAGGTATCAAACCGTTCGCATGCCCACATGAAGGGTGCGAAGCGCGGTATACAATTCGTCCAGATTTGAAAGATCACATCCGAAAAGTTCACACACGAGAACGGCCATTTAAGTGTTCCGTGTGCCAGAAATGTTTTTTAACTGGTTCAGTGTATTATCAACACCGATTGATTCACACGAATGATCGACGATACGGCTGCGAAGTGTGCAATAAACGTTTTTTTCGTGCAGATGCCCTGAACAATCACCGTCGAATTCACACGGACGAACGGCCGTATCCTTGTCCGGTTTGCGGACGCGAGTTCCGCCAAAAAGGCGATCGGAACAAACACGTGCGTACGCAACACTCAGTTTAA
Protein Sequence
MYEQENTFLKIHRLNPDGIVNSSIRLEIDCSNQVITNTVLTQAEINFDKHICNWGYFVDDKINLNYRHVEENNPTITVIKVGGLDELTPMNYITHINATINDSLGKDNYVFEETKKQQVKRINLPDNSGISCQNCDTSFPTKYQYQRHQCEFNAEKVVLKPEVAGKDLDKATRLRFECDICKKSFVSNNNLERHKNCHKNDSHNVCDFCNKSFVSENRLKIHKENHCKKGGDMTKFYRSDVIVWQCDECKQVFASQENGNKHVSKCILANHSIKEDEDDTSLFKLKTIYEENNSDSNQSQSDTSGFYKDGESNGLFKIVTEMLYQCEYCNRTYADKSVVLNHQKTHSTDKNYECIFCHSHFDNYQLATIHWQNKCNNESNVFYLPKMIYCEHCDRSFKSHEILYNHKNKKRHFTPKVHLKTEENNNEIRSENEKAIVKLIENMISKMDQNLFNAEQAVKIEHGDTTPVVGKKKRGRKRKNQKTELKYQKSVYEDGYQYQCERCPMVFRSILCLISHKETEHAATFCCEQCGQVVHSAKALMIHCRAHQSLKPYVCDQCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFKCSVCQKCFLTGSVYYQHRLIHTNDRRYGCEVCNKRFFRADALNNHRRIHTDERPYPCPVCGREFRQKGDRNKHVRTQHSV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_01039577;
80% Identity
-