Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.6 7e+03 -2.7 0.1 59 66 7 14 4 17 0.60

2 3 0.36 1.6e+03 -0.7 0.2 4 20 109 124 106 134 0.78

3 3 3.7e-16 1.7e-12 47.3 6.0 6 70 154 217 150 217 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.6	7e+03	-2.7	0.1	59	66	7	14	4	17	0.60
2	3	0.36	1.6e+03	-0.7	0.2	4	20	109	124	106	134	0.78
3	3	3.7e-16	1.7e-12	47.3	6.0	6	70	154	217	150	217	0.93

Coding Sequence: ATGACATCGAAAGGCAAATGCCGTCTTTGCGGCGAAGAAGTCAGTTTCACAATAGGGAATCCAGTCGAATTAGGATTTCATATGATTGATAGACATAATAGTGGAAGTGTAGGGCAATATGACATCCTTGAAGAATATCATAAATGTGTTAACACTGATCATGTCAAAGAGGAAGAATTAGAAGCTTGTCCAGATAAGTCTTGTGCTGGTAAACGAACGAAAGTAGAAACGAAGAGTGCTGGTGTTGGTAGTTGTAGAGCTAGTTATATTAAGAGTGGTGAAACTGGTAATTCTTTTGAAAGAATTCGCGGTGGGAAAGGAGCTGTTCAAGTAGATTGTAATTGTAATGCGAAACGAAAGACTAAGGGGGAGCGAGGAGGAAAAGGAAGAAGAAGACATTGTTATAGTAAAGGATTGTATAAGACTACATTAGAAACATGGACTAGCGCTGGAGGTTATGTTACCTGTCCTTCTTGTGGTAAAGAAGTGCGACCATTAGTGCGAAGCCAGAAGAACAAAGTAGCGTACACCTCTGTAGGCGCGACATTTTTATTAAGTTGTTGGCCATGCTGTTTCCTATTTCCACTAATGCACAAATGCTCCATCGATTTGTACTGCCCAAATTGCAAATATGCCCTTGGAACTTACGACGCGAGCTCAGGGAAAACGCGTGCTAATGGTCAAGTGCCACATATGGACCAAATGGATAAATAA
Protein Sequence: MTSKGKCRLCGEEVSFTIGNPVELGFHMIDRHNSGSVGQYDILEEYHKCVNTDHVKEEELEACPDKSCAGKRTKVETKSAGVGSCRASYIKSGETGNSFERIRGGKGAVQVDCNCNAKRKTKGERGGKGRRRHCYSKGLYKTTLETWTSAGGYVTCPSCGKEVRPLVRSQKNKVAYTSVGATFLLSCWPCCFLFPLMHKCSIDLYCPNCKYALGTYDASSGKTRANGQVPHMDQMDK

Sequence clustering based on sequence similarity using MMseqs2