Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.00098 6.7 7.8 0.0 22 52 69 99 63 99 0.86

2 7 0.00042 2.9 9.0 0.2 21 51 96 126 92 127 0.88

3 7 8.6e-05 0.59 11.2 0.2 22 52 125 155 119 156 0.86

4 7 0.047 3.2e+02 2.4 0.0 23 51 154 182 150 183 0.84

5 7 0.007 48 5.1 0.1 22 44 181 203 177 206 0.92

6 7 0.0031 22 6.2 0.7 23 47 210 234 203 239 0.84

7 7 0.027 1.8e+02 3.2 0.6 22 46 237 261 234 263 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.00098	6.7	7.8	0.0	22	52	69	99	63	99	0.86
2	7	0.00042	2.9	9.0	0.2	21	51	96	126	92	127	0.88
3	7	8.6e-05	0.59	11.2	0.2	22	52	125	155	119	156	0.86
4	7	0.047	3.2e+02	2.4	0.0	23	51	154	182	150	183	0.84
5	7	0.007	48	5.1	0.1	22	44	181	203	177	206	0.92
6	7	0.0031	22	6.2	0.7	23	47	210	234	203	239	0.84
7	7	0.027	1.8e+02	3.2	0.6	22	46	237	261	234	263	0.86

Coding Sequence: atgTGCATTCTTAACAAAGAGAAGCATAAAATTGATGTTAAAGCCGAACCCATTTCCAGTAGAGAAGCGAAAGAAAATACAAGGGCTGCAAATCTCGATAAAAATTTGCCACCCCTAAAACAGCATTCAAAAGTGCAGAATGCGCAAGATAATGACAAACTACTCGAAACGGAAAGTTTTCTGGTCAAACGCATCCATACCGAAGACCAATCCTTCACTTGCTGGGTGTGCAAAAAAGAATTTGCAGAGAAGAAAAATCTAACTAGACATATTCGAACACACAACGTCGAGAAGccatacaaatgtacaatttgcaaacGATCATTTAGTCAGAAGAACAATTTGACCACTCACGTGCGTATCCAAACATATAAGGAACCCTTCACTTGCTCAGTGTGCAACCAGGAATTTGCACAGAAGAGTAACCTAACTAGACACTTTCGAATACACACCGGCGTaaaaccatacaaatgtacaatttgcgAAGTATCACTCACTGGGAAGGATAATTTAACCTCTCACATGCGTATCTATATACATGAGAAACCCTTCTCTTGCTCGGTGTGCAACCAAGAATTTGCACGAAAGGATAACCTAACTAGACATATTCGAACCGACAGCGATGGaaaaccatacaaatgtataatttgcAAACGTTTATTTTGTCAGAAGAACCATTTGACCAGGCACATGCATATCCATACCCATGAGAAACTCTTCACTTGCTCAGTGTGCAATCAAGAATTTTCACGGCGGTATAACCTAACTAGACACACTCGATTGCACACCTGA
Protein Sequence: MCILNKEKHKIDVKAEPISSREAKENTRAANLDKNLPPLKQHSKVQNAQDNDKLLETESFLVKRIHTEDQSFTCWVCKKEFAEKKNLTRHIRTHNVEKPYKCTICKRSFSQKNNLTTHVRIQTYKEPFTCSVCNQEFAQKSNLTRHFRIHTGVKPYKCTICEVSLTGKDNLTSHMRIYIHEKPFSCSVCNQEFARKDNLTRHIRTDSDGKPYKCIICKRLFCQKNHLTRHMHIHTHEKLFTCSVCNQEFSRRYNLTRHTRLHT

Sequence clustering based on sequence similarity using MMseqs2