Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 9.8e-05 0.67 11.0 0.2 21 47 49 75 41 80 0.85

2 7 0.0076 53 5.0 0.2 23 52 79 108 73 108 0.86

3 7 0.0049 34 5.6 0.3 22 44 106 128 101 132 0.88

4 7 0.00085 5.9 8.0 0.3 21 52 133 164 128 164 0.87

5 7 0.009 62 4.7 0.5 21 46 161 186 157 192 0.80

6 7 0.00014 0.97 10.5 0.0 21 52 189 220 184 220 0.91

7 7 0.0011 7.3 7.7 0.1 21 46 217 242 214 244 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	9.8e-05	0.67	11.0	0.2	21	47	49	75	41	80	0.85
2	7	0.0076	53	5.0	0.2	23	52	79	108	73	108	0.86
3	7	0.0049	34	5.6	0.3	22	44	106	128	101	132	0.88
4	7	0.00085	5.9	8.0	0.3	21	52	133	164	128	164	0.87
5	7	0.009	62	4.7	0.5	21	46	161	186	157	192	0.80
6	7	0.00014	0.97	10.5	0.0	21	52	189	220	184	220	0.91
7	7	0.0011	7.3	7.7	0.1	21	46	217	242	214	244	0.90

Coding Sequence: ATGTTAAATCTGAACCCAACACTTGTAGAGAAACGGAAGAAATTACAGGCGTCGCCCCTGAAACAGCATTCAAAAAAGAAGGTTGGGCAAGATAATGAAAAACTATTCGAAATGGAAAGTATTCCTGTCAAACGCATCCATACCGAAGAGCAACCCTTCTCTTGTTGTGTGTGCAAAAAAGAATTTACAGAGAAGAAAAATCTAACTAGACACATTCGAACACACACCGACGTaaaaccatacaaatgtacaatttgcaaaGTATCACTTACTCGGAAGGCTAATTTATCCTCCCACATGCGTATCCATATACATGAGAAACCCTTCTCTTGCTCGGTGTGCAACCAAGAATTTGCACGACAGGATAACCTAACTAGACATATTCGAACCCACAGTGATGAAAAACCaaacaaatgtacaatttgcaaacGTTTATTTAGTCTGAAGAACCATTTGACCAGACACATGCGTATCCATACCCATGAGAAACCCTTCACTTGCTCAGTGTGCAATCAAGAATTTGCACGGCGGGATCACTTAACTAGACATACTCGAATCCACACCGGCGaaaaaccatacaaatgtGGAATTTGCGAACGATCATTTACCGAGTCAAGCAATTTGACCAAACACATGCGTATCCATACCCATGAGAAACCTTTCACTTGCTCAGTGTGCAATCAAGAATTTGCACGGTGGGATAACTTAACTAGACATACTCGATTGCACACCTGA
Protein Sequence: MLNLNPTLVEKRKKLQASPLKQHSKKKVGQDNEKLFEMESIPVKRIHTEEQPFSCCVCKKEFTEKKNLTRHIRTHTDVKPYKCTICKVSLTRKANLSSHMRIHIHEKPFSCSVCNQEFARQDNLTRHIRTHSDEKPNKCTICKRLFSLKNHLTRHMRIHTHEKPFTCSVCNQEFARRDHLTRHTRIHTGEKPYKCGICERSFTESSNLTKHMRIHTHEKPFTCSVCNQEFARWDNLTRHTRLHT

Sequence clustering based on sequence similarity using MMseqs2