Basic Information

Gene Symbol
-
Assembly
GCA_000004775.1
Location
GL274389.1:22318-458921[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 4.8e-13 2.3e-09 36.4 0.1 8 69 194 254 189 259 0.84

Sequence Information

Coding Sequence
ATGCCACcTCCTCCATCTCCATTAACTACTTCTACTTCAGAGGTTATGGACTACAGTATACATGGCACTCTTTCTCATAGACATTCAAATGCTATAAATCGCAACGGAGGTAGTAGTCCACCATTACCTCCTCCGCCGCCTCCGGATCAAGATGAACTTTCTCAATTCGGAAGATTAGTTTCATGTTCTGGAACAATAAAACCTATAGTGCCAGAAGAAGAGGATCTTCCAGGATGGGttccaaaaaattatatagaaaaagctgaAGTGGAAacatcaaattatttaatgcCAAAACGTCGGAAAACATTACCTTCttggaaaaatgttaaaaatgctgATTATTTAATAGATGAAATGGATGACAATACTACAGATTCTGAGGAGCAAAAGGCTGTAGCTGAATCAgatgtttataatataactGCAGATGAGTCTTCAtcaaaatcagaaaaatccGCAAACAGTAGTTTATCTATAAGTTCAAACAGATCGAAAAAAGGTCGTTTATCTCGTGGCGCTAGCCCTGGTAATGCGATCAGACAAAAAGTGTCTGTAGATATCAAGAATCCCGCATATCGAGAACCGTTCAAATATGGTTGGAAAAGAGAGTTGGTATATAGAGCTGGGGCTTCGGAAAACCAAGTTAGACGAATGGctgatatatattattatacaccagAAGGTAAAAAAGTTAGAAGTTTCCGCGAAGTTATCGGATCTTtgACAACTAGCGACTTGACTATTgataatttcacttttttcaaagagcCTCTTGGTATAAATGATCCACTCAAAGAAATTATTCGAGATGCAAAAAAAGCTAAAGATTCTTTTAGTAATAAATCTGCTAAGAAATTATCTAAAAAAGCCGTAGAATTACTCTcaacaaagaaaatatctataaaaaagGGAGTTGAAAAATCTCTTCCGGGGACGGTCGCATTCAAAGCATCATCTAAAACAGTAAAAGTGCCTGCAACTTTTAAGGTTAAATTACCACCTAAGAgggatattttaaaaaATGCTAAATCGCCTCCGATGATTCCAGTGGAAAATGAAGTTTCATCTCCGCCACTTTGGGGTACACCAAACATCAGAAAACAGCCCTTAACAGAGAAAAGttctttaattaaatcaaaaaaattgattaaGGCGAAAGTTCAGGAACCATGTAGCATTAGGTGCTCAGCTAGTATGGGATTGGTACCTAGTTTACAGTGCTATGTCTGCCTTTGTTTGTATCATTCTGAATGTGCTGGAAAACATGAAGTAAAACGGAGCCCTACTTTTGTTTGCAAGAATTGTCAACTAGAAATAGATGATTCTTTACAATATGAATCAGTACCTGCCCTAAATCCACCACCTTTGATTCCTATAAGTATTTTGAGCGCTCAAAACAGTATGCCAGTAGATCAAACAGGAACGCTTCCAAAACTACAGCTTATTCATAAATTGGATACTGAAGGTTCTACGCAGTCAGATGTGTTGAATATTAGTAAAATTGGATCATCtgataatcaaattattttaaatgaaaaaataaaaaaaaattggtatcctgaaaatgaaaataaattcttacCTGACCGAGAATTGGTATTACTGAAACCTGCTCAAAACATCGTCTCAatgaacaacaaaaaatttattgtgatACCAAAGAACAATGCCATGGCAGTACAACCAGCCATGACGTTAAGAAAAGACAAAATAGAAGATTCaaaactacattttttaaacaatgtaGATGTTTCCAGTTGTCAAACAGATATTGAGATGCTAAACCCTATACTAAATACTGCAAATGAATCAAACATGCATCTTCTGAATTCTGGCAAGAATATTAAATCCACAGTTGACAAATTAGAAAgttcaatttttgaaaatcccgTTGCATTATCAGATAAATCATTGTCACCAATCAgtactaatttatttaaagaaaaccTTTTTGACACACATATTTTATTGCACACAAATCCAGAAAACCAATACAATGTGTTTTCTTCatcaatgagaaaaaaaaaagttcttgcTGTGCATTACAAAGCAATGCAAttagatacatttttaaaaaatacaagGAAAAAGCAGACACTCCCGGATACAGATCATCATCAATACTTTATGGTTTCTGTTTGTGCTGGTTATCATGCtctttctcgaatttttcaatacttaAAAGTTCAAGAATTGTTACGTGCTGCCAGGGTTTGTCGTATGTGGCGCGATCTTGCAGCGCACCCTTCATTATGGAAAACCGTACGTATGAAAAACAGTCAAGTTACCGATTGGAATGGATTAGCTGACACTCTTAAAAGTCGAGGTACTCAACATTTAGATCttagaaaaatgttaattgtTGGTGAGGCAGATAATGTATGGAAGAAATTCATTGCTGTCATTCCAAGAATAacaactttaattaaattagaaaTGTGTCGATGTCCTGCTGAAGTTGTGGAAgaagttatgaaaaattgttcacAATTAAAAGTACTGAATGCTATGTCCATAAAATGCGATTCTTTAAACCTCGAATCAGCGAGTAGCTTAAACAATTGCAATGAATTAAGACTAAAAGCTATTAATGGTATGGCTATAGAAGGAGATCTAACACctttattacaaatttcaaaCATTACACATCTGAGTTTAACATCTGTCAAAGATCtcggcaaaaagaaaatagagatattaaaatctttaagCAGTCTTAAAACATTAGAACTTGGGGAATGCTCggattttccagaaaaatttGGCACTGCGGTATTAAgtaatttacataatttagaAAGACTGCGTCTTGAAAAAGGACAAGGATCATGCTGTACTTTTGATATTCTTGAAGGGATCGCTAAACTTGAAAATCTTACTCAATTAGAACTAGTAAACTTTGACGTAAAAAACggttttgataaatatttggCAAATTGCAAGAATATTAAAAGACTTTTAATAATACCTACTTATGTATCGCAGTCAGCAACGTCAAATAATATGATATTGGGCGGTGTAACTGAATTATCCAACAGTTTAACTCATTTTGTATGGGGAGTCACTCAAGAATTATTACGAGTAACAGAATTATTTGTTGATCAATGTAATCAAATGAGTAAGCAGATTACTGGGGATTCCATACCAGTTTTGAAGCCAGTTCCTTGCCTAAATCTGATTGACGATATTGCTGATAGTAAAACGCACAACCAAAAAGGTAATCTTTaa
Protein Sequence
MPPPPSPLTTSTSEVMDYSIHGTLSHRHSNAINRNGGSSPPLPPPPPPDQDELSQFGRLVSCSGTIKPIVPEEEDLPGWVPKNYIEKAEVETSNYLMPKRRKTLPSWKNVKNADYLIDEMDDNTTDSEEQKAVAESDVYNITADESSSKSEKSANSSLSISSNRSKKGRLSRGASPGNAIRQKVSVDIKNPAYREPFKYGWKRELVYRAGASENQVRRMADIYYYTPEGKKVRSFREVIGSLTTSDLTIDNFTFFKEPLGINDPLKEIIRDAKKAKDSFSNKSAKKLSKKAVELLSTKKISIKKGVEKSLPGTVAFKASSKTVKVPATFKVKLPPKRDILKNAKSPPMIPVENEVSSPPLWGTPNIRKQPLTEKSSLIKSKKLIKAKVQEPCSIRCSASMGLVPSLQCYVCLCLYHSECAGKHEVKRSPTFVCKNCQLEIDDSLQYESVPALNPPPLIPISILSAQNSMPVDQTGTLPKLQLIHKLDTEGSTQSDVLNISKIGSSDNQIILNEKIKKNWYPENENKFLPDRELVLLKPAQNIVSMNNKKFIVIPKNNAMAVQPAMTLRKDKIEDSKLHFLNNVDVSSCQTDIEMLNPILNTANESNMHLLNSGKNIKSTVDKLESSIFENPVALSDKSLSPISTNLFKENLFDTHILLHTNPENQYNVFSSSMRKKKVLAVHYKAMQLDTFLKNTRKKQTLPDTDHHQYFMVSVCAGYHALSRIFQYLKVQELLRAARVCRMWRDLAAHPSLWKTVRMKNSQVTDWNGLADTLKSRGTQHLDLRKMLIVGEADNVWKKFIAVIPRITTLIKLEMCRCPAEVVEEVMKNCSQLKVLNAMSIKCDSLNLESASSLNNCNELRLKAINGMAIEGDLTPLLQISNITHLSLTSVKDLGKKKIEILKSLSSLKTLELGECSDFPEKFGTAVLSNLHNLERLRLEKGQGSCCTFDILEGIAKLENLTQLELVNFDVKNGFDKYLANCKNIKRLLIIPTYVSQSATSNNMILGGVTELSNSLTHFVWGVTQELLRVTELFVDQCNQMSKQITGDSIPVLKPVPCLNLIDDIADSKTHNQKGNL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01037010;
90% Identity
iTF_01037010;
80% Identity
-