Basic Information

Gene Symbol
ZEB2
Assembly
GCA_905147345.1
Location
LR990354.1:7642446-7650345[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.0032 0.5 12.7 2.1 2 23 73 94 72 94 0.96
2 12 0.025 3.9 9.9 0.3 2 23 101 123 100 123 0.94
3 12 1 1.6e+02 4.8 0.2 2 23 131 153 130 153 0.89
4 12 1.8e-05 0.0028 19.8 2.1 1 23 159 181 159 181 0.96
5 12 7.2e-07 0.00011 24.2 1.3 1 23 187 209 187 209 0.96
6 12 0.00065 0.1 14.9 1.3 1 20 215 234 215 236 0.93
7 12 0.016 2.6 10.5 0.7 3 23 256 277 255 277 0.91
8 12 1e-05 0.0016 20.5 1.4 1 23 598 620 598 620 0.98
9 12 3.7e-06 0.00058 21.9 4.1 1 23 627 650 627 650 0.97
10 12 0.08 13 8.3 3.8 1 23 658 681 658 681 0.93
11 12 0.0083 1.3 11.4 3.5 2 23 688 711 687 711 0.92
12 12 0.00049 0.077 15.2 1.2 1 21 717 737 717 738 0.95

Sequence Information

Coding Sequence
ATGGATTCGAATTTACCATTTTTTAGTCTCCcattcgTGGATTCGGAGACTTCAGATTTTTTATCGAGGATCAAGCCGCAGGAGTGTGCGTACGATGAGTTGCACGCTACTTTACCATCCCATggggccttgctgggccccgaCGATGTCTTGGCTCAGTTTCTTTCTGGAGACGAGCCGCTGGAGGAGCCCGATCTGAACGGTCCTACTACGTTACACTGCGAGATCTGTAAGAAGCGATTCGATAATGCTAAGAAGTACTATGGACATTTACGAGTCCATTCTAAGGATAATCTTTGGGTTTGTGAGCAATGTCCTGACCAGAAGTTTTCCACAAAGCAGTTGCTGATGAAACATGGGCTAACTCACAAGCCTCTGGAGAGAGAATGGAAGTGTCTGCAGTGCACAATGGCTTTTGAGGCTCTGTGGAAACTGCAGCAACACCTGTTTGCTAAGCATTTGAACTACAAGCCACACAACTGTGATCAATGTGAGAAGTCTTTCACAAAGCCTTCAGACCTGGAGAAACATAAGAGCATACATAGTGATGTAAAGAAACATGCGTGTCCCGAGTGCGACATGCGCTTCAAGGACGAGTCGAACCTGAAGCGGCACCTGCTGCGTCACAGCGGCACCAAGCCTTATTGCTGCACGGGATGCGGGACGAGGTTTAAACAGCTGGCGTCAATGAAGCGGCACGCACAGAACTGCGCGCTCAGCAAATGTAGCAGCGAGCCGGCGGACGCGCGCACGCGCAAGAACCACTGCCGAGTGTGCGGCATGAGCTTCCAGTACAAGAGCGCCTTGTTAGagcacgccgtccgGCAACATACGGACGCGGGGAGTGCTGCGCAAAACGCGAAGCCGCCTGAACCCGAAAAAGATGATAAAAGCAATCTTAATGACACGAACCGCATTGTAGACAACATCGTGGACGACATCCTCTCCGCCGAAGACGACTACATGACCATGTCAACACAGAACGAGATACTAAACGTCTACAACCCAAATGATATCGACAACAATCCAGAAAACTTGATGCAAATAGAACTATTAAAAGAAATGAACCAACTGCACATTCTAGATGGAGAACTTTTCTACAATGATATAGACTTCGACAGCATCCAACCTAGCCACATGTTCAACACAAACACAAATGACATGGACTATAGTGCTGATAAGAATGCTGAGATTCTATTCGATTTTACTGAAGGAAACAAAAGTATGGATCAAGATATCATGAACACTTTGTTCCATGTCAAAGCTGAGTACTTACCTGATGAATTACTAAATCCACCAGAAATAATAAATCCTCCGGAGAAAAATAACGAACTAGACAATCATAATCACGTATCTGTGAACGAATGTGCAACGATATTTGAAAGTGACGTCGATTTAGAAGCTAGCACGAATTTAGCCGCAAATTTGAATCAACTGATTGGTGAAAATAGCGTCCAGTATATCTCGACAGAAGACGATGATACCtttataattagtttaaataGTGAAATTGATGCTGAGCAGTTGACGGATATGTTAAATATAGGAGTAGAATTAGTTAACGATAAGACTAAGGAGCCAAGTGTACCTGAAGTGAAGCAGGAAACTGTGAGTCTAGCAAATATTGAGCTTTATGTCAAGATTGATAAGCAGACGAAAGAGCCACAAAATGAGCAATTGGTACCTATGGTCATTAAACTGGAAGAGCCTATGAGTGTTCCGCCTGCAAGTTTGGTAGCCACAGAAGAGCAAAAAAAAGTAACGAAGAGAAAGCCCAAGAAGAAAGTGTTGTATGTTTGTAGAACTTGCGATAAGGCGTTCAATAAGAAAGATAATTATCGATCTCATCTAGCAACCCACGAGCCATCTCTCCGCCGGCACAAGTGCAAGGTGTGCGGGGAGCGCTTCAGTTACCGCTCGACGCTGAACAAGCACACGCGCAGCCTGCACACGCCCTACGTCCAGGAGGAGCACTGCTGTCAGATATGCGAGCGCAACTTCAAGTTCGCGTGGATGTTGCGGGAGCACTTTGAACGCGACCACGACGGCCTGACGCCGCATGCGTGCGACTATAAAGACTGTCGCAAAAGTTTCTTCAAGAAATCAGATCTCGTCGTGCATAAGAGGTTCCACACTGGCGAGCGTCCGTACTCGTGCGATATCTGCAAGAGAAGGTTTCTTCAGGCGAGCCATCTCAAGCGACACGAGAGGGACGTCGACTGTACCAAGTTGTAA
Protein Sequence
MDSNLPFFSLPFVDSETSDFLSRIKPQECAYDELHATLPSHGALLGPDDVLAQFLSGDEPLEEPDLNGPTTLHCEICKKRFDNAKKYYGHLRVHSKDNLWVCEQCPDQKFSTKQLLMKHGLTHKPLEREWKCLQCTMAFEALWKLQQHLFAKHLNYKPHNCDQCEKSFTKPSDLEKHKSIHSDVKKHACPECDMRFKDESNLKRHLLRHSGTKPYCCTGCGTRFKQLASMKRHAQNCALSKCSSEPADARTRKNHCRVCGMSFQYKSALLEHAVRQHTDAGSAAQNAKPPEPEKDDKSNLNDTNRIVDNIVDDILSAEDDYMTMSTQNEILNVYNPNDIDNNPENLMQIELLKEMNQLHILDGELFYNDIDFDSIQPSHMFNTNTNDMDYSADKNAEILFDFTEGNKSMDQDIMNTLFHVKAEYLPDELLNPPEIINPPEKNNELDNHNHVSVNECATIFESDVDLEASTNLAANLNQLIGENSVQYISTEDDDTFIISLNSEIDAEQLTDMLNIGVELVNDKTKEPSVPEVKQETVSLANIELYVKIDKQTKEPQNEQLVPMVIKLEEPMSVPPASLVATEEQKKVTKRKPKKKVLYVCRTCDKAFNKKDNYRSHLATHEPSLRRHKCKVCGERFSYRSTLNKHTRSLHTPYVQEEHCCQICERNFKFAWMLREHFERDHDGLTPHACDYKDCRKSFFKKSDLVVHKRFHTGERPYSCDICKRRFLQASHLKRHERDVDCTKL*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01527643;
90% Identity
iTF_01030495;
80% Identity
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