Basic Information

Gene Symbol
MBD2
Assembly
GCA_958510865.1
Location
OY294064.1:44576355-44577019[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.8e-11 1.8e-07 31.9 0.2 12 73 17 97 8 101 0.86

Sequence Information

Coding Sequence
ATGAACGGTATTTTGGACAGAAGTAAATACGAATATGGAAACCAGGCAAATAAGAGATGGCAAAGAGAAGAAGTTCTCCGAAAATCAGGCATATCAGTCGGCAAAGTCGATGTTATGTACTACAATAGGACTATGAGAAACGATGCTTCTCTAGTGCCTCCGATAAGACAAACGGCGTCGATTTTTAAGCAACCCGTAACCATACACAAAACACAAGAGAGTAAAGTGAaatctgatttcaaaaatggcAACCAAGAGAAGCCAAAACAACTTATGTGGGAGAAGAGGCTTGAAGGTATGAGAGCTTGCGACAGAGACGGTACAGAATTCGTTAGCATGGAACTCCTTAAAGGTCTAAAACCAGTAGGTCCAAATGTTTCAGGGGAAACGATGATTCAGAGCGTTGCTACTGCTCTACATGTATCTGGGCAACCTGTGACAGGTCAAAACGGTCCCAAAGTCCTTCTAGAAAAGAATCCTGGTGTCTACATAGACCCTAAGCAACCTCTGGTTCAAGCTGTGAGTATAACAGATGAGGACATTAAAAGACAGGAGGAGAAAGTTCTAGAGGCCAGAAGGAGGCTTCAGGAAGCATTAAAGATGTAA
Protein Sequence
MNGILDRSKYEYGNQANKRWQREEVLRKSGISVGKVDVMYYNRTMRNDASLVPPIRQTASIFKQPVTIHKTQESKVKSDFKNGNQEKPKQLMWEKRLEGMRACDRDGTEFVSMELLKGLKPVGPNVSGETMIQSVATALHVSGQPVTGQNGPKVLLEKNPGVYIDPKQPLVQAVSITDEDIKRQEEKVLEARRRLQEALKM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00020284;
90% Identity
iTF_00020284;
80% Identity
-