Basic Information

Gene Symbol
MBD2
Assembly
GCA_943737955.2
Location
OX031314.1:53899848-53901731[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.3e-25 7.4e-22 77.9 0.0 1 73 7 74 7 78 0.95
2 2 5.3e-05 0.31 11.8 0.0 27 74 162 218 149 221 0.87

Sequence Information

Coding Sequence
ATGAATTCAAGTATAACAATAGAACGAAAACGAGTGGATTGTAATTCCTTGCCCAAGGGTTGGCAACGGGAAGAGGTTGTACGTAAATCTGGTATCTCTGCGGAAAAAATAGATGTTTACTACTATAGTCCCACAGGCAAAAAAATCGAAAGTAAGCCGCAGTTAGCTCGTCAACTAGGCGATAACATAGACATATCCACCTTCGATTTCCAAACTGGGAACATTATAAAAAATCTATCCCCACCATCTATTTCCCTATATCGATGCGGTAAAGGTATCGGCGGTATTAATCCAAACTGCGGTTCTACGCCGACAACAGCACCAGTTGTTGGAACGTCTTTAGCTGGCAGTACAAACGCATCGAACTCCTCAAAGCGCAAATATAAGTCACAACATGATTCTGACATAACAGCAAGCAGTAGCATCAATTCTAATATTTCTGTAGCCAGCACATCGAGTTTACGTCACCAATTAGAACTCAGCCGTGCACTACGAACAGATATATCCTTGGTTCCTCCAATACGCCAAACGGCATCTATTTTCAAACAACCCGTTACAGTTGTTCGAAATCATGAAAATTCAAAAGTGAAGCATGACACTAAGCATGGAAACCAAGATAAACCAAAGCAATTATTTTGGGAAAAACGGTTGGAGCACTTACGGGCATGTCATGCAACAGGCGAAGAATTCGATAATATTGGACTTCCGAAAGGAATAAAATCGGTGGGACCTAATATTAACGAACAGACGGTGTTGCAGTCCCTTGCAACTGCGCTACATGTTTTAAATACACCCGTCACAGGACAGAGTTACACAAAACACGAAACGACTAAAAACAGCCAAGCTTTTTTAAACCCTGACCAACCTCTAATGCAATCAGTTATTATTTCGGATGAAGATATACGTCGGCAGGAGGAACGTGTGACCGCAGCCAGGCGAAAATTGCAAGACGCGCTGAAAGCataa
Protein Sequence
MNSSITIERKRVDCNSLPKGWQREEVVRKSGISAEKIDVYYYSPTGKKIESKPQLARQLGDNIDISTFDFQTGNIIKNLSPPSISLYRCGKGIGGINPNCGSTPTTAPVVGTSLAGSTNASNSSKRKYKSQHDSDITASSSINSNISVASTSSLRHQLELSRALRTDISLVPPIRQTASIFKQPVTVVRNHENSKVKHDTKHGNQDKPKQLFWEKRLEHLRACHATGEEFDNIGLPKGIKSVGPNINEQTVLQSLATALHVLNTPVTGQSYTKHETTKNSQAFLNPDQPLMQSVIISDEDIRRQEERVTAARRKLQDALKA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01415016;
90% Identity
-
80% Identity
-