Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 3.6e-29 2.1e-25 88.2 0.1 2 64 10 73 9 74 0.98

2 2 0.087 5e+02 0.5 0.0 9 35 86 114 83 146 0.74

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	3.6e-29	2.1e-25	88.2	0.1	2	64	10	73	9	74	0.98
2	2	0.087	5e+02	0.5	0.0	9	35	86	114	83	146	0.74

Coding Sequence: atgagtGAAAGTCAACAAAgtcgttttgaaaaatctttaggcttattaacaacaaagttcgttaatttattacaaaaatctaCTGGTGGCGTCCTAGATTTGAAAGTGGCTGCTGATTTATTGGCTGTTCGACAAAAACGTCGAATTTACGATATAACGAATGTCCTTGAAGGTATTGGACTTATCGAGAAGAAGAGCAAAAACAGTATACAATGGAAGCCATATACATATAAAGATTCAGTGCCTGGTTATAATACACAAGAATTCGCAGTAAAAATAGCAAATCTAAAGAGTGAAATATGTAAATTAGATGAGTACGAACAGGAATTAGATAAGCAGAGAATGTGGATTGAACAaagtataaaaaatacaacagaaGATGCGCAAACTAAACGTTATCTATATGTAAcaaatgatgatttatttaatgtttttaacaATGACGAAACTGTCATTATCTTAAATGCACCTATTAACACAACTACACTAAAATATCaacacaacaataatttaaattacctAAAAGTCCAATCGAAAGGTGGTCCAATTGTTGCTAGTCTACTTGGTGATCCTCCTGTAGAGAACGACGAGGAAAATTCAAAGAGAAAACGTTCGAATAAAATCacaattaaaaaagaaCCAGAGGAACCTGAAACGAAACGTAAACATTACGATGACGATGATTCGGATTTGGTAGCGGCTGAAATTTTATTCAGAAAAGTCTCAAATGACATCAACGATAATTTCTATGATTATGATGAATCATTAGAATCGTTAGATAAAGACCATAACGATCCATTTGTTCGTTTAAGTCCATTGCCGTTCAGTCAAGATTACTCGTTTGGTCTGCTGGAGAACGAAGGGATTTGCGATCTGTTCGATATAAAATCGGTTTCGGCTTAA
Protein Sequence: MSESQQSRFEKSLGLLTTKFVNLLQKSTGGVLDLKVAADLLAVRQKRRIYDITNVLEGIGLIEKKSKNSIQWKPYTYKDSVPGYNTQEFAVKIANLKSEICKLDEYEQELDKQRMWIEQSIKNTTEDAQTKRYLYVTNDDLFNVFNNDETVIILNAPINTTTLKYQHNNNLNYLKVQSKGGPIVASLLGDPPVENDEENSKRKRSNKITIKKEPEEPETKRKHYDDDDSDLVAAEILFRKVSNDINDNFYDYDESLESLDKDHNDPFVRLSPLPFSQDYSFGLLENEGICDLFDIKSVSA

Sequence clustering based on sequence similarity using MMseqs2