Mmin003622.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Mycalesis mineus
Gene Symbol
MBD-R2
Assembly
GCA_034621355.1
Location
CM067884.1:4504197-4527284[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.2e-17 8.1e-14 51.7 0.0 5 68 776 838 772 849 0.92

Sequence Information

Coding Sequence
ATGGCtgttaaaaaatgttgtatAGAAAATTGTTGTTCTACATTAACAAGACCTGAAGATATTGGAGTGTCTTACCACAAGTTTCCTAAAGATACGGTATTACGTCAGTCCTGGCTGACTGTTACCCAACAAACACCAAATAACATAGATAATACTACATATGTGTGCTCGCGACACTTTTGTAAAAGTGATTTTAAAGTTTACCAAGAGTCGAAATATATCCTGAAGTCAGatGCTGTACCGTCTATATTTTCTTGgaacgaaaatataaaaattaataaaatggacaCAGAATTAAGTATTGAAAAAGAGGCAAATAATGAAGATAATCCGCAAAATATTTCATCAAGTAGCAAAGAATCAGAAGAAGAGAATATTgcctcaataaaaaaatatattgagaaacaagaaaaagaaattcaagATAAAGAAAATgctaaaaagaataaacaagCTGTTAAAAATGTTTCTGAAATGGAGAACTTAGAGACAACAAATAGTTCAGAATTAGACCATTCAGTTAAACAAGAAAGTATATCGGAACATATTGAACAAGCGGAGAATGTGGTGATGGGTATGAGTGTTATGGACATGATACACTCTGAATCTGAAACTCACCTTGACTTGAAGAGTGATGTGAAATCCATACCAGCTAATTCCAAACATAGCTTGAATCATAAAGGTAACAGTGTGGCATTGTCTGTGGGTTCTAAAGTGAATGCCAAAGATTTTGCCGAACTGTGGCATCCAGCGGAGATACTGGAAGTCGACTACGACGAGATGGAAGTGTTGGTGCATTACGAAAATATACCCAACAAACTTGACGAATGGATATCTATAAATAGTTCTAGACTTaggccaataaataaaaataaatccacaTCAGCAACTACATCCGCGACTCCTGAAGTGGCTCCCAGCCCAGAGACAATGGAAGCAGTGGTAAAAGAAGAGATCAAAGAAGAGAAGCCGAAACTACAGTTTATAGTGGGAGAGAGATGTTTGGCCCGATGGAGGGATAATCGGAGATTTATTGCAACTATTGCTAACGATTTTGACAATGGCATATACGAGATCGTTTTCGACGACGGCTTTCACTGGAAGTGCAGCGGGTCTAGATTGTATAAACTAAAAGACCCCGCAAAGTATTCCGATAGTTTGACCATCGACACCTCAATGTCTCCTAAAGCCTCAACCCCATCCCCGGTTCAACCCGGGGCCGGTTCTAGTGATACCCCCAATCCGTTAAACCCCCCTCCTGTATTCCACAAACACCTCTTTGATCCCACCCGTGATTATTTAGGTTCTAAGTCCGAACGCCGTGAAATGAAACGCAAGCTAAATATCAAGGAAATATTTAATATCGGTcaaaagaaaaggaaaaaagaaactACACCCAAGGAGAAAGTTGCTCGCGTCGTTAAAGAGAAGAAACCGAAGGtgcaaaaaatagaaaaaagcaAAGTGAAACCAGAAAAAATGAAAGTCAAAGTTGAAgtcaaaaatgaaattcctgATGCGATAGCTTCAATAATCGGTACTGTCGCTAAAGTAGAAGTGGAAAAACCCGCAACTCTGGAAATAAAGATGGAAGTAGACACGCAAGAGGAAGATCAACACGTGGAAGATAAAGTTGAGATTAAAGAAGAATCAGCTGAAGGAGAGATGGGCAGTGATAAGATTACGTTAGACGATTTGGTGGACAACAGTTCGACGGTGAGCGCGGATGTCGAATTCCCCAATGAGTTGGATATGACGATGTTAACAACTGAAcctgACATTGAAGAGGAACAGAAGTTGGAGAATTTCGAAAAACCGGACGAAAGCAAACAAGAGGTCATAGAGAAAATGAAGGAGGTCATAAACAAGCTAGAAAGCGGTCTTAACACTGGAACCGAGGATCCTcagaatcccgttggttccccAAAACCAGAACCAAAAACTGAACCACTAGTAGATATTGTAGAAGTAAATCCTGCTGTAAGCAAACCTGACAAGGAAACCGTGAGGCATACCAAGAAAAAGTTGTCCAAGAtcaagaaaagtaaaaagttgtgGCTTTTACAGGAGAAAAagGTAGAGAAGCAAGTGGAGAAAGTGACGAGTGAATTAGAAGAGATGAAACGCCAAATGGCAGAGATGAGGAAGCAAATGGCCAGCAAGCCGGAGCAGTTGTTATCTCCGGGCAGACCGAGTGAGATGCCCGAGAGCTTCCTGCTGCCCGGCGAGTGGTGCTGCAAGTGGGTCAACGGCCAGCCGGTGGGCACTGTCAGCGAGATCGGAGGCGACCCTAACAACAAGATGGCGCTGCCGCGACGCAGTGTACAGGTAGAAGACAAAAGATTGCCAGAAGGCTGGACAAAACACATGGTCCGTAGAAGGCTGGGTCAGTCGGCCGGAAAATGGGATGTTGTTTTAGTAAGtccAACGAACCACCGATTCCACACTAAAAACGACATGCGCAACTATATAGAACAAAACCAGAGTGAGGAGTTAAAGCCTTACGAGTACGCATTGTTAGATTTTGGGGTGCACCTCAAGTTATCACGCCGTATGGGATGGTACACTAGTAACGATGGGAACTCTGACACGGGGGTCGTGAACACCATGTCTCCTTTGGAAAAGACGAAGAAGTTCCGCATCAGTAGGAAAGAGGACAGGAAGGAGAAGAAAAAGAGGAAGAAGCAGCTCGCTGCGTTACGTCGACGAAGTTCTTTATATGTTACTCCTGGAACAAGTGGTGCAATTGAAACAAATACCATACCCGAGGGATTCCCTGCCTTAGAAGATGGATATGTATATGTCGGTTCTCTGAAAGTTCAGATACTCGAAAATCTATTGCGTTGTCCGGCCGAGGGGTGCTTCAAAAACTTTCGCAACAATACGCTCCTGCAGATGCacatcaaacattatcacagaGAACTGAGGAAGATGTTGGGAGCTACGCCGAAAGTTCTCGATCTGGCTAGAAAGAGGACCAAGCCTACAGGCATCGAGAGGATAAGGCAGCCAGTTtccaaagtattaaaaataaaaatttcgcGCCCCCCAAAACGTATCGAAGAACCAAAACCAAAAACGGAACCCAAAGTGCCTCTTGAAATAAACGTCGAAAACGATGCTACGGTGCCGGTGAAAATAGATCCCCCGATACCGAGGTCGATGGATTCGCCGAAACTTCGCCAAGCTTTAGTGAACAAACCGGTCAAAAGGCCCAAAGTGTTGCTGCCGGTCCGCCGACCGGACCCACCGGATCCCGCGTCTGAAGTGGAAGAAGAATGCCCGTCACTAGTGTACGAAGATCATCCGGTAGATTCTCCAATGGCAACTATCGAACCGCAAGATTTCGAAACTGCCATATCAACGCATACCGTCACAAAACCGATAGACGATTCTAGAAGGAGGCCTGAGAAGAAACGCAAAAGCTTTGCGGCCGTCTGCAAGAGACCTGGCAGCGAAGAGGATGAATGGTACGGAATGAATTCTGACTTGGATACGAGATCCAGTTACCCAGGATCCGGTACACCTGATTCGAAGACAATGGACAAGGTGTTGACCAATCAGCAAGCGGTTTCTTCAGAGTCTGCGGAAGACCAGAAAGATGccaatatgtatatgtattctGAAACCGGGGAACGTATAAAGATCGAACATATGAAGAGGGAGGAGATCATCAACTGCCATTGCGGTTTCCGCGAGGAGGACGGGCTGATGGTGCAGTGCGAGCTGTGCTTGTGTTGGCAGCACGCGCTGTGCCACAACATACAGAAGGAGTCTGAGGTTCCCGAAAAATATACATGCAGTATATGCCTAAATCCGAAACGCGGTCGCCGCTCTAAGCGGTTCTTACACGATCAAGATAGGTTATACGAAGGTCTCCTACCCGGGGCGAAGCCCTGCGAGTCTCTGCGGCGCTCCCACGAGCTGTCGGGTAACTTGCTGAGGATACAAGACGCCTTGCACGCACTCCGGGTCAAATATTATGTTGCTACAAAAAAAGACCACCCTAAACTCTACCTCTGGGCAAAGGATTGGGAGAGTACAGAAGTAAATATGACACAAGAGAGACTGAACTCCGATTACTCGGACTTGAACATAATCATTAATAACATAGGCAAAGAGAATTTGCCAGTCAAACCTGATGATTCGCACTTAGACACGAGGGCGTCTGATGATTTGGACGAGAGATTCAGTCATAGGGATTCCTCCAGTACACTGATGAATCTCACAGCAGCGTTGTCTAGCCCCAGTGGAACTTCTTTGGATCTGCCGATAACAACATCCGAGTTGGAGAGATTGGCAAAGTCTGTACAAGAGCAAGAGGTGCGCAACGTGTCGGCGCCGCAGCCCGAGGCGGCCATCGAGAACGGCGCGTGCCGCGAGCGGCTGCTGCGACACGTGCAGCGCTGCCAGGCGCTCATCGACGCCAGGCTCGACTCTATCGAGGCGCAGGTTGCAGAACTGGAGTCACAAGATCCCTCATTCGAAGACGACGAGACTGCGGACTACTTCCCTCGCACCAAGCAAACCGTGCAGATGCTGATGAGAGACCTCGACACCATGGAAGAGCTCGGCATTATCACATAA
Protein Sequence
MAVKKCCIENCCSTLTRPEDIGVSYHKFPKDTVLRQSWLTVTQQTPNNIDNTTYVCSRHFCKSDFKVYQESKYILKSDAVPSIFSWNENIKINKMDTELSIEKEANNEDNPQNISSSSKESEEENIASIKKYIEKQEKEIQDKENAKKNKQAVKNVSEMENLETTNSSELDHSVKQESISEHIEQAENVVMGMSVMDMIHSESETHLDLKSDVKSIPANSKHSLNHKGNSVALSVGSKVNAKDFAELWHPAEILEVDYDEMEVLVHYENIPNKLDEWISINSSRLRPINKNKSTSATTSATPEVAPSPETMEAVVKEEIKEEKPKLQFIVGERCLARWRDNRRFIATIANDFDNGIYEIVFDDGFHWKCSGSRLYKLKDPAKYSDSLTIDTSMSPKASTPSPVQPGAGSSDTPNPLNPPPVFHKHLFDPTRDYLGSKSERREMKRKLNIKEIFNIGQKKRKKETTPKEKVARVVKEKKPKVQKIEKSKVKPEKMKVKVEVKNEIPDAIASIIGTVAKVEVEKPATLEIKMEVDTQEEDQHVEDKVEIKEESAEGEMGSDKITLDDLVDNSSTVSADVEFPNELDMTMLTTEPDIEEEQKLENFEKPDESKQEVIEKMKEVINKLESGLNTGTEDPQNPVGSPKPEPKTEPLVDIVEVNPAVSKPDKETVRHTKKKLSKIKKSKKLWLLQEKKVEKQVEKVTSELEEMKRQMAEMRKQMASKPEQLLSPGRPSEMPESFLLPGEWCCKWVNGQPVGTVSEIGGDPNNKMALPRRSVQVEDKRLPEGWTKHMVRRRLGQSAGKWDVVLVSPTNHRFHTKNDMRNYIEQNQSEELKPYEYALLDFGVHLKLSRRMGWYTSNDGNSDTGVVNTMSPLEKTKKFRISRKEDRKEKKKRKKQLAALRRRSSLYVTPGTSGAIETNTIPEGFPALEDGYVYVGSLKVQILENLLRCPAEGCFKNFRNNTLLQMHIKHYHRELRKMLGATPKVLDLARKRTKPTGIERIRQPVSKVLKIKISRPPKRIEEPKPKTEPKVPLEINVENDATVPVKIDPPIPRSMDSPKLRQALVNKPVKRPKVLLPVRRPDPPDPASEVEEECPSLVYEDHPVDSPMATIEPQDFETAISTHTVTKPIDDSRRRPEKKRKSFAAVCKRPGSEEDEWYGMNSDLDTRSSYPGSGTPDSKTMDKVLTNQQAVSSESAEDQKDANMYMYSETGERIKIEHMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIQKESEVPEKYTCSICLNPKRGRRSKRFLHDQDRLYEGLLPGAKPCESLRRSHELSGNLLRIQDALHALRVKYYVATKKDHPKLYLWAKDWESTEVNMTQERLNSDYSDLNIIINNIGKENLPVKPDDSHLDTRASDDLDERFSHRDSSSTLMNLTAALSSPSGTSLDLPITTSELERLAKSVQEQEVRNVSAPQPEAAIENGACRERLLRHVQRCQALIDARLDSIEAQVAELESQDPSFEDDETADYFPRTKQTVQMLMRDLDTMEELGIIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01021304; iTF_00205203; iTF_00205140;
90% Identity
iTF_01021304;
80% Identity
iTF_01021304;