Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.00056 11 7.3 0.1 21 45 18 42 6 45 0.86

2 5 9.2e-06 0.18 13.0 0.4 21 46 46 71 42 75 0.88

3 5 0.0038 74 4.7 0.3 21 45 75 99 69 105 0.86

4 5 0.0037 72 4.7 0.1 22 44 104 126 99 130 0.86

5 5 0.0028 56 5.1 0.1 26 48 192 214 179 218 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.00056	11	7.3	0.1	21	45	18	42	6	45	0.86
2	5	9.2e-06	0.18	13.0	0.4	21	46	46	71	42	75	0.88
3	5	0.0038	74	4.7	0.3	21	45	75	99	69	105	0.86
4	5	0.0037	72	4.7	0.1	22	44	104	126	99	130	0.86
5	5	0.0028	56	5.1	0.1	26	48	192	214	179	218	0.88

Coding Sequence: ATGGAATTCTCTCAGAGCAGCAACCTGAAAGCGCATTGTCGAACCCATACAGGTGAAAGACCTTACATTTGTATAGCTTGCCAGGCTGGATTCTCAAATAGCAGCAACCTAAAGGAACACATAAAAAAACATACGGGAGAAAAACCTTATACTTGTCCAAATTGTCACCAAAAATTCGCTAATAGTTCTAGCTTGAAACGTCACATTAGACGTATACACACCCAAGAAAAACCATTTAACTGTCCTGAATGTTGTATCAAATTCTCTTCAACAAGTAATTTAAATATACATTTAAGAACCCATACGGGGGAAAAGAATTTTTTGTGTCAAATTTGTAATGTTGGATTTTCTCAGAGAAGCAATATGAGGAGTCATATGCGGACACATATCGGGAGCTTAGAGTACAAATGTGAGTTATGTAGCGTAGAATTTTCTAAAAGAGGAGGTTTAAAAGCCCACATGAGAGTGCATTTGGGCGATAAACCATTCAATTGCGACATGTGCGATGAAAAATTTACCTACAAAACTTTATTGAAAGCTCATATAAGAGTCCATACGGGGAAAAAAGTACTTAAATGTGACGAGTGTAAGGCAGAATTTGTTAATACCAAAAATTTGAAAAGACATGTGCGTCAGACTCATATAGAAACTAAATTGCATTTGTGTAAGAAATGCAATGTGGGGTTCCCAAAAACGTGTATGTTAAGAAACCATTCGTGTGTTGAAGAAGTGATTGTTAGTTAA
Protein Sequence: MEFSQSSNLKAHCRTHTGERPYICIACQAGFSNSSNLKEHIKKHTGEKPYTCPNCHQKFANSSSLKRHIRRIHTQEKPFNCPECCIKFSSTSNLNIHLRTHTGEKNFLCQICNVGFSQRSNMRSHMRTHIGSLEYKCELCSVEFSKRGGLKAHMRVHLGDKPFNCDMCDEKFTYKTLLKAHIRVHTGKKVLKCDECKAEFVNTKNLKRHVRQTHIETKLHLCKKCNVGFPKTCMLRNHSCVEEVIVS

Sequence clustering based on sequence similarity using MMseqs2