Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.11 58 5.0 0.1 23 44 98 119 80 124 0.77

2 6 0.092 49 5.2 0.0 25 44 122 141 115 158 0.78

3 6 0.18 95 4.3 0.1 25 44 197 216 188 222 0.83

4 6 0.25 1.3e+02 3.9 0.1 25 44 219 238 215 243 0.82

5 6 0.22 1.1e+02 4.1 0.1 25 44 241 260 238 265 0.82

6 6 0.052 28 6.1 0.0 25 48 263 285 256 296 0.73

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.11	58	5.0	0.1	23	44	98	119	80	124	0.77
2	6	0.092	49	5.2	0.0	25	44	122	141	115	158	0.78
3	6	0.18	95	4.3	0.1	25	44	197	216	188	222	0.83
4	6	0.25	1.3e+02	3.9	0.1	25	44	219	238	215	243	0.82
5	6	0.22	1.1e+02	4.1	0.1	25	44	241	260	238	265	0.82
6	6	0.052	28	6.1	0.0	25	48	263	285	256	296	0.73

Coding Sequence: ATGCTGCGATCGGGGGGTAGCGTCCAGGGTTCTTTGGTGACCAGGCCAGGCTCTGCAGATGGGGACCGGGCAGCGTACAGCTATAGCCAACAACGACCAGCCGTGACTTCCACGTCAGGGCGGGCAGACGGTGGAGGTACGGCTCCGGAACAATGGTTCTGGCTGGGTTCAGCTACGAGATGCTGCAGTACAGTTGCTGCTTCCTACACAATAGTCCTCAGCCCTATCTCTACAGCCGAGTACCGACATACTGACATACGATGTTGGGACAAAGCAGTAGTATTAGGAGAAGCCTCCGCCGCTGCCGCTGTCCTGTCTACTTGCAGCAAATACTACAAAGCAGTAGTATTAGGAGAAGCCTCCGCCGCTGCCGCTGTCCTGTCTACTTGCAGCGAATACTACAAAGCAGTAGTATTAGGAGAAGCCTCCGCCCGCTGCCGCTGTCCTGTCTACTTGCAGCGAATACTACAAAGCAGTAGTATTAAAAGAAGCCTCCGCCGCTGCCGATGTCCTGAGAAGCCTCCGCCGCTGCCGCTGTCCTCTACTTGCAGCGAATACTACAAAGCAGTAGTATTAGGAGCAGCCTCCGCCGCTGCCGCTGTCCTGTCTACTTGCAGCGAATACTACAAAGCAGTAGTATTAGGAGAAGCCTCCGCCGCTGCCGCTGTCCTGTCTACTTGCAGCAAATACTACAAAGCAGTAGTATTAGGAGAAGCCTCCGCCGCTGCCGCTGTCCTGTCTACTTGCAGCGAATACTACAAAGCAGTAGTATTAGGAGAAGCCTCCGCCGCTGCCGCTGTCCTGTCTACTTGCAGCGAATACTACAAAGCAGTAGTATTAGGAGAAGCCTCCGCCGCTGCCGCTGTCCTCTACTTGCAGCAAATACTACATTGA
Protein Sequence: MLRSGGSVQGSLVTRPGSADGDRAAYSYSQQRPAVTSTSGRADGGGTAPEQWFWLGSATRCCSTVAASYTIVLSPISTAEYRHTDIRCWDKAVVLGEASAAAAVLSTCSKYYKAVVLGEASAAAAVLSTCSEYYKAVVLGEASARCRCPVYLQRILQSSSIKRSLRRCRCPEKPPPLPLSSTCSEYYKAVVLGAASAAAAVLSTCSEYYKAVVLGEASAAAAVLSTCSKYYKAVVLGEASAAAAVLSTCSEYYKAVVLGEASAAAAVLSTCSEYYKAVVLGEASAAAAVLYLQQILH

Sequence clustering based on sequence similarity using MMseqs2