Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.35 2.2e+03 -0.3 0.0 20 45 8 33 4 39 0.81

2 7 0.00016 1 10.3 0.0 23 45 67 89 64 96 0.90

3 7 0.033 2.1e+02 2.9 0.0 22 48 94 119 89 122 0.85

4 7 0.0092 59 4.7 0.1 23 46 151 174 143 180 0.81

5 7 0.042 2.7e+02 2.6 0.1 21 44 177 200 169 208 0.81

6 7 0.00088 5.5 8.0 0.1 21 49 205 233 198 236 0.85

7 7 0.0063 40 5.2 0.0 21 44 233 256 231 262 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.35	2.2e+03	-0.3	0.0	20	45	8	33	4	39	0.81
2	7	0.00016	1	10.3	0.0	23	45	67	89	64	96	0.90
3	7	0.033	2.1e+02	2.9	0.0	22	48	94	119	89	122	0.85
4	7	0.0092	59	4.7	0.1	23	46	151	174	143	180	0.81
5	7	0.042	2.7e+02	2.6	0.1	21	44	177	200	169	208	0.81
6	7	0.00088	5.5	8.0	0.1	21	49	205	233	198	236	0.85
7	7	0.0063	40	5.2	0.0	21	44	233	256	231	262	0.89

Coding Sequence: ATGTATCACAAGAACacgaaaaaaaaggaacaagaaTTAATCTGCCATATGTGTCCAAAAAGGTTCACTAAAGTATCTCATTTAAACAGACACGTTAAAACTCATAATACCGAGAAACTGTTCAAGTGTTCGCAGTGTGATAAGACTTTTGCGAGACAGGAGCAACTAAGTCATCATATGAATGTGCATACTGGGATTAAACCACATACCTGTGATATTTGCTTCAAAGGGTTCAATCAGATCTCCAATTTGAAAGATCATATGAGAACTCACAATGGGGATAGACCGTTTTTGTGTTCAACTTGCGGAAAAGGCTTTAATCAGTTAGGAAATCTCAGGCAACATACGATTAGACATACTGGAATAAAGGCACATCTTTGTAGTACTTGTGGCAATGGGTTCGCTAGTAAGGGTGAACTATCTGCACATCTCCGGAAACATACAGGTGCAAGGCCATTTGTGTGTCCCATCTGCGGACACGGCTTTACCACCTCCAGCTCTCTcacaaaacataaaagaatCCATTCCGGAGAAAAACCCTACGAATGCGACGTTTGCAAAATGAAATTTTCCAGGTCCGGTATATTGGCAAGGCATAAACGTACCCATACGGGTGAGAAACCATATGTTTGTAAGTTCTGTTCTAAGGCATTTTCCCAGTCCAACGATCTGACGTCACATCTTCGAATACACACTGGAGAAAAGCCGTATATTTGTGATGAATGTGGGCAAGCGTTTAGGCAGAGTTCGGCACTGAAGACGCACAAAAAGACACATATTGATAAGAACATTATAATTGATACTAAGCCAATCTTAATTAATAATGTTGCGCATGAAACCTTTTTTTACAACTTTCCAGTGacattaataagtattttttatcagGTACCTATGCTTTAA
Protein Sequence: MYHKNTKKKEQELICHMCPKRFTKVSHLNRHVKTHNTEKLFKCSQCDKTFARQEQLSHHMNVHTGIKPHTCDICFKGFNQISNLKDHMRTHNGDRPFLCSTCGKGFNQLGNLRQHTIRHTGIKAHLCSTCGNGFASKGELSAHLRKHTGARPFVCPICGHGFTTSSSLTKHKRIHSGEKPYECDVCKMKFSRSGILARHKRTHTGEKPYVCKFCSKAFSQSNDLTSHLRIHTGEKPYICDECGQAFRQSSALKTHKKTHIDKNIIIDTKPILINNVAHETFFYNFPVTLISIFYQVPML

Sequence clustering based on sequence similarity using MMseqs2