Basic Information

Transcription Factor Domain

TF Family: AF-4
Domain: AF-4 domain
PFAM: PF05110
TF Group: Unclassified Structure
Description: This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental disabilities [1]. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.031 1.3e+03 -0.5 0.2 139 213 25 98 8 116 0.39

2 3 3.5e-09 0.00014 22.4 0.9 32 126 134 236 129 264 0.67

3 3 0.00032 13 6.0 0.3 349 381 265 298 253 312 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.031	1.3e+03	-0.5	0.2	139	213	25	98	8	116	0.39
2	3	3.5e-09	0.00014	22.4	0.9	32	126	134	236	129	264	0.67
3	3	0.00032	13	6.0	0.3	349	381	265	298	253	312	0.81

Coding Sequence: atgcccgtaataggccaacgccttatctgcgagatagccagGTACGAGCGCGACCGCGAGTCGGCGACGCTCCACCAACAGCAGCACGCGCCGGCCGCGGGCGCcggcgcggcgggcggcggcgcggcggcggcggcggcggcgggccGGCAGCGCGAGCGCGACCGCGACCGCGAGCGCGAGCGGTCGGCGCGCGCGCTGctgtcggcggcggcggcggagcGCGAGCGCGAGCGCGACACGGCGCGCGCGCACGCCGTGCCCGCCGCGATGCCCGCCGGGCCCGACCGCTCCGAGCGGCCCGCCGTCGCCGCGCAAccctccgccgccgccgccgcacacCCGCCGCCGCTCGACCGCTTGCACGGCCACCTACTGGGCCACTCGCAGCCGCCCGATTCGCTCTTTCGGGCCCCCGTCAAGGTTTCTCCCGCCGCCAACGACAAAGTGACCCAGCAAATCCAGAGCAAACTTGGCGACTACCGTCTCGTGAAACATCTACTTGACGACCCCAAAGCCTTCGCTGGCATCTTTGGGGAACCAGCTAGTCCAGCGCCGTGTGTGCCATCGAGAAACTGCGAATTCAAGAAACCACATCATGCCACTTCCtccaattcttcttcttccatgcaAAATGGCCGCCCGAACAACCACCGCACTCAGTTCAAGGCTCCCGAAACTGGAGTTTCTACTAACCCAGGATCCAGCTTCCCACCTTCACGACCCACTCTTCAAGGAAGGATGCACAACGGCACTACCACTCCCCagaactCATTGGACTGCAACGGACAAATTGATACCATCCTAAAGGAAATGAAATCTCTCCCTTTAACACCACTCACGGACATTGCGCCAACACCCCGCAAGGAAACCGACTCCAAGTTCGACTTCACCCTCGCCACGTGGAagACGTACGTTTCTGGAACCGTTACGCATATCGTCCTCGTCCTCACGGCGGCGAGCGGGGTCGGAAGGACAGGAAATCAGGTGGTCTCGGTATCAAAACGTTTCGTCTGGCGGGGCGGCGGCGGAGCGGCAGCGGGATCGGGAGCGGGAACGGCCAGTAGATAA
Protein Sequence: MPVIGQRLICEIARYERDRESATLHQQQHAPAAGAGAAGGGAAAAAAAGRQRERDRDRERERSARALLSAAAAERERERDTARAHAVPAAMPAGPDRSERPAVAAQPSAAAAAHPPPLDRLHGHLLGHSQPPDSLFRAPVKVSPAANDKVTQQIQSKLGDYRLVKHLLDDPKAFAGIFGEPASPAPCVPSRNCEFKKPHHATSSNSSSSMQNGRPNNHRTQFKAPETGVSTNPGSSFPPSRPTLQGRMHNGTTTPQNSLDCNGQIDTILKEMKSLPLTPLTDIAPTPRKETDSKFDFTLATWKTYVSGTVTHIVLVLTAASGVGRTGNQVVSVSKRFVWRGGGGAAAGSGAGTASR

Sequence clustering based on sequence similarity using MMseqs2