Basic Information

Gene Symbol
-
Assembly
GCA_940306215.1
Location
OW675808.1:8952538-8957985[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.6e-12 6.4e-09 35.4 0.1 9 72 247 308 243 311 0.88
2 2 1.9 7.6e+03 -3.2 0.0 8 27 375 393 372 397 0.72

Sequence Information

Coding Sequence
ATGGATGTCGTTGCTGGTGATATAAATGGCGGGAACGCCGAGGTGGCGCGCGACGATTCTGGTCCAATAGTAATTGAAGCGCCGGTGCCAGAACTGTCGGAAACAGTGGAAAATCAGGAAAACACTGGTGAAGAAGTTAAAATGGACGAGCAAGAGGTTAATGGTGATGTTAAAAGTGTATCAAATAAAAAGAGTGTTACGCCAATTGCTAGAAGAAAACTTCGTAAATCCAAGGCCAATTCTACGactaatattgaaattgatcaGGAACCAAAAGTCAAAGGACAAAAAAGAAAGCTATCTGAACCTGATGCTATTAATTCTGACGAGTCAATTGACTTCAATGGGTTTGATATTActagaaatataaatgaacaaagtgtggaaattttacaaaaactTATTGTCGAAGCTGAAGCATGGGAAACACAAAATACAAAACGCCTGAGGCGTTCGATATCAAAAGGTCCACGCagaaatattgaattcaaaaCTGTGGATGATCATTCAGGCATTTTGGATactaatgatattaaaatgcGTATTGATGATGCTGTTGATCCACTTGATATACCAAAACATAAAAAGGAATCTGATAAATCTGATATTGAATCAGATGATAcacaaaaacatgaaaatttatcaattagaAGTCCACCAATGGCAGTACAAAGGCAGCGTGGTACAAGTGGTGGTAAACAGAAAAATTcagttgatatattaaatcCACTCTTTAGAGAGCCATTCAAATACGGTTGGAAACGTGAAATTGTATACATTGGTGAgactgaaaatttattaaagaaaacaatagaagtttattattatacaccaAAAGGAAAGAAAGTTCGAAGTCTCAGAGAGATTGCTGAATTTTtaaatacAAAAGAGTTGACAATAGACAACTTTACATTTTTAAAAGAGCCTACGGGTGTTAATGATCCCGAATACGAAATAATTAGGGAAGAACCCAAATCGgTTACTACACCAACTACGGGTTcattgaatacaaaaaaaatgggaTCGGTTGGTAAAAGAGGAGGTATAACGAGGAGAATGGCTGGAAAAATGGCATCACCACCTTCACCATCAGCTAAAGCCACGGGAAAATGGTCACCGGTGAAGGGTAATACGCCTGCTGGTTTTAAAGTTAAAGTTTCGGGAAAAAAAGGTTCTCAAAAAAAATCTGTGTCACCACCGAAAGAAACGGACGTACTCACACCTATGTGGAGTAATACATCGGGTGTAACACGACGCAATCAAGCAGCAACGGAAAAAACTGTGTCATCACATAAACCGACAAAACGATCATTAAAGCCTAAAGTTCAAGAGCCATGCAGTATTCGATGTTCAATGAGTATGGGTCTCATACCAAGTCTTCAATGTTGCGTTTGCCTATGTTTATATCATCCTGAATGTGTTGGTCATAAAGAGTTATCAgcaaatgaagaatatatttgtaagAATTGTCGGCCAAAcgatgaagtaaaaaaatccATAACACCACCTCCATTAATTCCAATAAGTATGATTGGATCGCAAAATTTAAAATCTGGACACTTGTcagcaattgaaaaaatatctccATCTAAATCACAAAAAACTCCGGTGTCAGAGAATGCCATGGACTCACCAATCAAAGTAGCAGGAAAAAGTTCACGACATTCTAACATTGCATTGTCTACACCAAATAGAACGAACAATTCTTCATTGTGGTTTGAGCGAGCTAACAGAGAATTTCTTCACAGACAAGACGTGTCTGAACCAAAACCAGCGCAAAATATTGCTCTACTTGCTGGTAAACGATACATTGTTGTTCCTAAAAATAATGCTATGTCTGTACAACCAGCGATAGCCGCACGACCAGATAAAATGCAAAATCAATCATCGTTTATGGATGATATTTTTCCGACAAGTACTCCAACAAGTGATACTGCAACCAAGAAACCTCGAGAGTCATCGTCACCTTTGTCAGAGTCATTTAATGAAGATAACATGAACCAAAGTGAAGAAGCATCTGATACAGCAAACAAAGACGAGCAGGTTAAATCAGATTTGACAAATTTAAAAGTATCAGAAAATGAAACTTTACCCGATGAACCGTCTGCAACTGCGATGAATGTCGAGGCAACTATTGAATCTAATACATCTGAGGATGTATCGTCTAATGTTCCTGTGGTTGAAGAAGAACCTAATTCGTGCGTTGAAACAATCGctaatgttgatgataaaatggaaaaaataacagaagaaccggaaaaaaattcagttccCGAAGTCATTCCTGAAAATacagaaatagaaaaaaatacaacagtTGAGATGGATACTGATGAGAAACACGAGACTATCGAGATaaaaaaaCCGCCTCAAATAGTGGAAATTGATCAACGACAATACTTTATGGCTACTGTTTGTTCAGGATATAATGCATTGACTCGAGTCTTTCAATATCTCAAAGTGCAAGAACTTCTTCGTGCTTCACGTGTATGTAAAATGTGGCGAGACATTGCAGCACAACCAGCACTGTGGAAAACCGTTCGAATGAAGAATAGCCAAGTGTCGGATTGGAAAGGATTGGCAGCGTCATTACAGAGGCACGGGACACAACATCTTGATTTGAGAAAAATGCTAATACCTGGTGAATCAGATgatatttggaataattttgtattagcGATACCAAGCGTTACAAGTCTCACTAAATTAGAATTGTGTCGATGTCCAGTGATGGTtgttgagaaaattattaaatcctGTCCGCAATTGGAGGTTTTATGCGCAATGTCAATGAAATGTGACTGGTTGAATTTAGAATCCATTGATAAATTGGAACGATGCCATGAACTTAGGCTCAAAGCAATTACCGGAATGTCATTACATGATGATCTCACGCCACTAAGTCAACTGACGCAATTAACACATTTGAGTTTGACATCGGTAAAAGAATTGggcaaaaagaaaattgaagtaTTGGGATCATTGATAAATCTTGAGACATTAGAATTGGGTGAATGCTCTGATTTTCCAGCTAAATTTGGTACTGCGGTTATGTGTAAATTTACGAAACTCGAACGTTTGAGATTGGAAAAAGGTCAAGGCACATGTTGCacatttgatatattaaatggtGTTgctaaattagaaaaattgcATCAATTAGAGTTGGTGAACTTTGATGTGAAAAATGGTTTTGATAAACGTTTGGccaattgtaaaaatatcaaGAGGCTACTTATTATCCCAACTTACATATCACAATCAGCCACATCGAATAATATGGTACTTGGTGGTGTCACTGAATTATCGAATAATCTTACACACTTTGTTTGGGGTGTAACATTAGAATTGTTACGTGTTACGGAATTATTTGTAGATCAGtgtaatcaaatgaataaacaaatttcgGGCGATTCAATACCTGTATTGAAACCGGTGCCATGTTTGAAATTAATCGAGGATAGTACAGTTGAAAATGACACGACAAaaggtGAAGACAAACAGATGAATTTAACAAATCCACAAGTAGATATTTTACCGTTGCCgcaattacaaaaattattattgactgCATTGCCCAAGACACgagtgaaaatattaaaaatacctTTCCATGCAACCTGGAGACAAAGTATTTCCGATTCATCAtcgcaataa
Protein Sequence
MDVVAGDINGGNAEVARDDSGPIVIEAPVPELSETVENQENTGEEVKMDEQEVNGDVKSVSNKKSVTPIARRKLRKSKANSTTNIEIDQEPKVKGQKRKLSEPDAINSDESIDFNGFDITRNINEQSVEILQKLIVEAEAWETQNTKRLRRSISKGPRRNIEFKTVDDHSGILDTNDIKMRIDDAVDPLDIPKHKKESDKSDIESDDTQKHENLSIRSPPMAVQRQRGTSGGKQKNSVDILNPLFREPFKYGWKREIVYIGETENLLKKTIEVYYYTPKGKKVRSLREIAEFLNTKELTIDNFTFLKEPTGVNDPEYEIIREEPKSVTTPTTGSLNTKKMGSVGKRGGITRRMAGKMASPPSPSAKATGKWSPVKGNTPAGFKVKVSGKKGSQKKSVSPPKETDVLTPMWSNTSGVTRRNQAATEKTVSSHKPTKRSLKPKVQEPCSIRCSMSMGLIPSLQCCVCLCLYHPECVGHKELSANEEYICKNCRPNDEVKKSITPPPLIPISMIGSQNLKSGHLSAIEKISPSKSQKTPVSENAMDSPIKVAGKSSRHSNIALSTPNRTNNSSLWFERANREFLHRQDVSEPKPAQNIALLAGKRYIVVPKNNAMSVQPAIAARPDKMQNQSSFMDDIFPTSTPTSDTATKKPRESSSPLSESFNEDNMNQSEEASDTANKDEQVKSDLTNLKVSENETLPDEPSATAMNVEATIESNTSEDVSSNVPVVEEEPNSCVETIANVDDKMEKITEEPEKNSVPEVIPENTEIEKNTTVEMDTDEKHETIEIKKPPQIVEIDQRQYFMATVCSGYNALTRVFQYLKVQELLRASRVCKMWRDIAAQPALWKTVRMKNSQVSDWKGLAASLQRHGTQHLDLRKMLIPGESDDIWNNFVLAIPSVTSLTKLELCRCPVMVVEKIIKSCPQLEVLCAMSMKCDWLNLESIDKLERCHELRLKAITGMSLHDDLTPLSQLTQLTHLSLTSVKELGKKKIEVLGSLINLETLELGECSDFPAKFGTAVMCKFTKLERLRLEKGQGTCCTFDILNGVAKLEKLHQLELVNFDVKNGFDKRLANCKNIKRLLIIPTYISQSATSNNMVLGGVTELSNNLTHFVWGVTLELLRVTELFVDQCNQMNKQISGDSIPVLKPVPCLKLIEDSTVENDTTKGEDKQMNLTNPQVDILPLPQLQKLLLTALPKTRVKILKIPFHATWRQSISDSSSQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01000549;
90% Identity
iTF_01000549;
80% Identity
-