Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_940306215.1
Location
OW675806.1:2144840-2154519[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 0.82 3.2e+03 -2.1 0.0 43 72 232 261 232 266 0.84
2 2 2e-17 7.8e-14 51.2 0.1 6 69 560 623 555 633 0.83

Sequence Information

Coding Sequence
ATGAAACGGCGGCGAATTACGCGGCGATCGCGTGCTAACAGTAGAGTAGTACTAGTCGCAAGGACATTAAGAATGGCGCGCAAATGTTTGGTGAAAAATTGTGAGATAAACGATGAATCTGTACGTGCAATTGGTTTGTCACTTCATAAATTTCCAAGAGATCCTGTATTGAGAAGCAATTGGTTTATTAATTGTGGCATACAAATGAATCACAGACCGCAATCTATCGAATTTATTTGTCACAGACATTTTTGTCGGAGTGATTATGATGAGCAGAAAGTAAAGACTAATGGTAAACGATTTATTCTAAAAAAAGGTTCATTGCCGACTATCTTcgagaattataataatcatccagatcCTATAATTCCTCTTGGACAAAATTCAAATGTTTCTTATCCACAAGAGGATTTAGATCTTATTAATTCGGAGGTGATGAATCTCAATCATGCAGATTCATCAATGTGTTCAAGCGATACATCAAGAATTTTATCAGAAGTGGACAGAAATTGTTCAGGAGTGAATTCAACGTTAAACTcaacaacaaatttattgaatacgTCTGAACTGTCAGatgtttgtaataataaatgtcatgCAAGTGATATTAATGAAGTTCATAAAATtgagatgaatgaaaatattagagaaaaaattatattaactaAAAATTCATCTGTTGAGCTTCCACCTTTATCAACGATAACAAAACTTGTGAAGAACATTGATCAAACAACAAATGttaataaagaagaaattaaaaatttcaatgttaCAAAATCAGATCGCATTAAGCGAATTGGAAGAAGTGAAAAACTAACAAAAGATGAACAACGCTTGCGAGTTAATAGAAgtggattaaaattttttcccgaCGCCAAATTGGAAGCTAAagatttcaatgaaaaatgGTATGCAGCACGAGTTGTTGAGACAGATTGGGTTGACCGCGAAGTTTTGATACACTTTGACAAATGGAGTTCGAGATTTGATGAGTGGATTCCAATGGACAGTTCACGATTACGGGTACCTCAAATTCCATTAAGagaACCAAAAATGCGTGGGTTTACAGTTGGCGAGAGAATACTAGCAACTTGGGCAGATGGAAGAAAATATCCAGCTAGAGTGAATGCAGTATTAGGAAACGacAGATACGAtgtattatttgatgatggtTATGCAAAAGTAGTACGATCATCTAAAATGACAAAAGTTGCGTCCACAACGACGAAGGCTGTGGACAAAGTTACAGAGTCTGAACCATATATTGGTAGTAAACAAGAACGTAGAGATAAAAAACGAAAACACACAATTATGGAATTGTTTCAACATAAAAGGAGATCAAAACCCGATGGTAGTGCTAGTAGTAGTGCTATCAAAAAAGACGGGAAATCGTATGATGATCgattagtaaatataaatcataataataatggcgATAAAAATGCTGCCGTTGGTGATGGTTACTACGATTCAAGTTCAGAATTGTTACACggttttgaaaataaaaaaccaaaagtgaaaaattattcaagaagAAAACAACGAGAATCATTGGCGAAAACTGTGGATACTGACCATGAGAATGACTCTGGTCCTGAATGGATTGACGGAGAACCACAAGGAATTGAATCATTCGTTGTTGATGGCAATGACGGTTCGCGCCGTTCAATAATTGTGTCAGATAAGAAATTGCCATCTGGGTGgcaaaaacattttatacaaCGTAGAAGTGGAAGTTCAGCTGGAAAATGGgatgttttatttcttcataaattAACTGGAAAGAAATTTCGatcaaaaaatgatattagaatatttttggAGGCTCAAGGCCAAATTGGGTTTGATCCAGATATGTTTGATTTTTGTATTCATCGACGAAAACGGCCTGGTAGTTCAAAATCAAAATCTGATACACCCGTAgaagtgcaaaaaaaaataaaaaccattttACCAAAAACAAAGATTCCTTCTGAAGTGACAgacgatttattattaacttcaGCATACAATACAATAGTTCCAGTTGTGACATCAACTACATCAGTTGACGACAGTgcAGTGTTTATTGGTGGCCTCCGTGTTGAGATGGAAGATAGTGCTTACAAATGTCCAAAAGAGGGATGTTGCAAAACTTTTCGCAAAGAAAATCTTCTTCAAATGcacataaaacattatcatcCTGAATTCTCAAAATATTTAGGATCTACACCAAATGTCGCAGATTTAGCATACGCACGCACAATTGGCGAATCTTTTTTGGATATTACACCTAAAAAAACTTCGAATGTGACTGATAGAGGTGgaaaattggaaaaacgaaaaattggACATGATAAATCTTCAGCTCCTACGCAATTTGCACATTCACCAGGACAATCTGCGTTGTCATCACCCTcactttttgtttctttatcaTCTGCGCatgtaaataatgatattcaaGCAGGAGCTGGCAATTTTCACAATGCAAATATTTCACGTGACGATATGAAATTTGAAATGATGTCACCAGCTTCGAATGCCCATCTCGATATTGATGAAGACATCGGTAAGAAATCCGATGACAACTGTGCAATGTCACCGGGAGCTTTGTTCGATATGCAAAAACGTGAAGTAAAATCACAAATTGGGATTAAAACGTTGTTACCAGTTCGGCCGATCGCACTTTCCACGAGCGACACCCAAAGAAATGAtcgatcaaaattaattaccgttgataatataaatattgaaaagggAAAAGGTTACCGTAAACGACAACTGTCTGAATACAGTTCTGATACATCAACAAAGAGCAAAAGACGACATGTGGGCGTACATGAATTCACAGATGATTATGGAGATTTAGAGGATAGTGCATTAGATGCTGAAGGTCCTGCAGCTCTTGTTTATAGATTCAGTCGTAGAAAATCAGATACGAATAACGACGACAATAGTCAGAGTAGTCAGCTAAACGATTCACATATTGAAAAAAGTGATACTGCGATaacacataataataatgatctaAAAGatGGTGGTGACGGTATCATGATGTTGATTAATGGTGAATTGGTGAAAGTCGAACAATTGCGacgtgaagaaataataaactgTACGTGCGGTTTTATGGAAGAAGATGGGCTCATGATTCAATGTGACCTATGCCTTTGTTGGCAACATGGTCATTGTAATTCTATTGAACGGGAAAAAGATGTgccagaaaaatatatttgctttATTTGTCGTCATCCGTATCGTCAAAGACCATCACAAAAGTATATTCACGATCAGGATTGGATAAAAGAAGGAAAATTACCAAGcTTCTCGAAAAGGACAAAGAATCAGGCTGGTATTAATCAACGAATTGCCATGCTCAAACGTTCTTATGATTTGGTCAGTATACTGCATCAAGTCAAACAAATTCTGCAAAGTTtgagagtaaaaataaatgttgcgCAAAAAAAGGATCATCCAAAGCTATACTTGTGGGCAAAAAATTGGGATAAATCAGATATACCAAAACCCAATGTGGAGCCTGTACCAAtactagaaataattaaaaatgaaccTGAGTCAATGGCAGATGATATGGAAAATAGACAACAAAgtgattcaataaaattagaaaCGAAACCACCAATAAAAGATGATCTTGATGTTAAATCAATAGCATCTGACAcagaattaatgaaaattcttgAAGGTAATACAACAGTGTCGGATGACAcgaagatgatgaaaaatgaagaCATAACAGGGAATAATGATGGGCAAATTTTATTAGACgctttaacaaaaaataatggtcttgattatttgaaatgcaataatgatgaaaaaacgATGGGAATAAAACTTGAGAATACCAATAGGCAGAATCGAGCAACTACtcctaaaaatataaatgaaagtgaAAAATCATTGATGGaaagtaaaaatttgaaatcaaAACATTTTCAACCATTGCAATCATTTATTCCTGAGCCTGAAGCACCAATTGATCCTGCCGAATGCCGTTTACGTTTACTTGAGCATATTGAACATTTTCAAAATCATATTGAAGCACGATTAACAACAGTTGAGGCGCAACTCATCGTTTTAGAAGTCATAGATGACCATAATGAGATTATCGAATCGTCAACATTAGATGTTCATTCTCGGATAAAACAAACCATTCAAATGTTGTTACGAGATCTCAATACTGTAAGAAAGCTGGCGGCTTTATGTTGA
Protein Sequence
MKRRRITRRSRANSRVVLVARTLRMARKCLVKNCEINDESVRAIGLSLHKFPRDPVLRSNWFINCGIQMNHRPQSIEFICHRHFCRSDYDEQKVKTNGKRFILKKGSLPTIFENYNNHPDPIIPLGQNSNVSYPQEDLDLINSEVMNLNHADSSMCSSDTSRILSEVDRNCSGVNSTLNSTTNLLNTSELSDVCNNKCHASDINEVHKIEMNENIREKIILTKNSSVELPPLSTITKLVKNIDQTTNVNKEEIKNFNVTKSDRIKRIGRSEKLTKDEQRLRVNRSGLKFFPDAKLEAKDFNEKWYAARVVETDWVDREVLIHFDKWSSRFDEWIPMDSSRLRVPQIPLREPKMRGFTVGERILATWADGRKYPARVNAVLGNDRYDVLFDDGYAKVVRSSKMTKVASTTTKAVDKVTESEPYIGSKQERRDKKRKHTIMELFQHKRRSKPDGSASSSAIKKDGKSYDDRLVNINHNNNGDKNAAVGDGYYDSSSELLHGFENKKPKVKNYSRRKQRESLAKTVDTDHENDSGPEWIDGEPQGIESFVVDGNDGSRRSIIVSDKKLPSGWQKHFIQRRSGSSAGKWDVLFLHKLTGKKFRSKNDIRIFLEAQGQIGFDPDMFDFCIHRRKRPGSSKSKSDTPVEVQKKIKTILPKTKIPSEVTDDLLLTSAYNTIVPVVTSTTSVDDSAVFIGGLRVEMEDSAYKCPKEGCCKTFRKENLLQMHIKHYHPEFSKYLGSTPNVADLAYARTIGESFLDITPKKTSNVTDRGGKLEKRKIGHDKSSAPTQFAHSPGQSALSSPSLFVSLSSAHVNNDIQAGAGNFHNANISRDDMKFEMMSPASNAHLDIDEDIGKKSDDNCAMSPGALFDMQKREVKSQIGIKTLLPVRPIALSTSDTQRNDRSKLITVDNINIEKGKGYRKRQLSEYSSDTSTKSKRRHVGVHEFTDDYGDLEDSALDAEGPAALVYRFSRRKSDTNNDDNSQSSQLNDSHIEKSDTAITHNNNDLKDGGDGIMMLINGELVKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNSIEREKDVPEKYICFICRHPYRQRPSQKYIHDQDWIKEGKLPSFSKRTKNQAGINQRIAMLKRSYDLVSILHQVKQILQSLRVKINVAQKKDHPKLYLWAKNWDKSDIPKPNVEPVPILEIIKNEPESMADDMENRQQSDSIKLETKPPIKDDLDVKSIASDTELMKILEGNTTVSDDTKMMKNEDITGNNDGQILLDALTKNNGLDYLKCNNDEKTMGIKLENTNRQNRATTPKNINESEKSLMESKNLKSKHFQPLQSFIPEPEAPIDPAECRLRLLEHIEHFQNHIEARLTTVEAQLIVLEVIDDHNEIIESSTLDVHSRIKQTIQMLLRDLNTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01000547;
90% Identity
iTF_01000592;
80% Identity
iTF_01001314;