Basic Information

Insect: Microctonus aethiopoides
Gene Symbol: gsb
Assembly: GCA_030347275.1
Location: JAQQBS010000003.1:7137730-7153891[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 7.1e-74 1.3e-70 235.0 0.9 1 125 19 143 19 143 0.99

2 2 3.3 6.2e+03 -3.0 0.0 23 67 357 372 341 386 0.59

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	7.1e-74	1.3e-70	235.0	0.9	1	125	19	143	19	143	0.99
2	2	3.3	6.2e+03	-3.0	0.0	23	67	357	372	341	386	0.59

Sequence Information

Coding Sequence: ATGGCTGTCAGTACACTTAATATGGCACCGTATTTCACTGGATATCCTTTTCAAggacAAGGACGAGTGAATCAATTGGGTGgtgtttttataaatggtcGACCATTGCCTAATCATATTCGATTGAAAATCGTTGAAATGGCAGCTTCTGGTGTGCGGCCATGTGTAATATCACGACAGCTTCGTGTGTCGCATGGATGTGTATCGAAAATACTTAATAGATATCAAGAAACGGGTTCCATTAGACCTGGTGTAATTGGTGGAAGTAAACCCAGAGTCACAACACCAGAAGTTGAAGCAAAAATGGAGGATCTTAAGAGACAAAATCCAGCAATATTTTCATGGGAAATCCGGGAAAAATTAGTCAaggATGGTGTTTGTGAAAAAGGCGCAGTACCATCAGCATCAAGTATATCAAGGCTACTGCGAGGACCATCAAATCAAACACGTCCCGGAGATGATCCTCGACGTAATCATTCGATAAACGGCATTCTCGGCGGTAGCAGTGGCGATGATTCGGATACTGAAAGCGAGCCTGGAATTGCACTTAAACGAAAACAAAGACGTAGCAGGACGACTTTTACTGGTGAACAATTGGAGCAACTTGAAGCTGCATTTCTTCGTACACAATATCCTGATGTCTATACCAGAGAAGAACTTGCACAAAAgacGAAACTTACTGAAGCTCGAGTTCAAGTGTGGTTTAGTAATAGACGAGCACGTTTACGCAAACAACTAAATAGCCAACAACTCAATGCCTTCAATACAATGAGTTTACAATCATTTCAAACTCAACATTATCCAAGTGGCGCTGAGAATTATCAAAGTTATGGTCAGGCATCAGTAGCTGCTGCTGCAGCAACTACTACGGGATATCCTTCACAACACTACAATTATGGCGAGAATTATTATAGTACACAGCAACAGTGGCCTCGAGCGACATCTGAAAACTATGGACTTTTCAACAGTTCTCACTATGGATCCGCGAATATTCCATCGAATTTATCACCAAGCAATTTGAATCTTGGCGGTTTGGCCGGGAGTATGAGTCCAACTGGTGCAAATATGAGCGCTTGTATGGTACAAAGTGCAACTTCTGGTGTGACACCAACAGCAACAGGAATGAGCCATCATCATGTGACACCTCACAGTCCCAGCGAAGCTAAAAGTGGTTATCCATATCTTGGAGGTATTGACTCACAAGTCTGTGGTCGAGTtcactaa
Protein Sequence: MAVSTLNMAPYFTGYPFQGQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPRVTTPEVEAKMEDLKRQNPAIFSWEIREKLVKDGVCEKGAVPSASSISRLLRGPSNQTRPGDDPRRNHSINGILGGSSGDDSDTESEPGIALKRKQRRSRTTFTGEQLEQLEAAFLRTQYPDVYTREELAQKTKLTEARVQVWFSNRRARLRKQLNSQQLNAFNTMSLQSFQTQHYPSGAENYQSYGQASVAAAAATTTGYPSQHYNYGENYYSTQQQWPRATSENYGLFNSSHYGSANIPSNLSPSNLNLGGLAGSMSPTGANMSACMVQSATSGVTPTATGMSHHHVTPHSPSEAKSGYPYLGGIDSQVCGRVH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00718374;
90% Identity: iTF_00317417;
80% Identity: iTF_01000395;